Chemistry can be defined as the study of matter and the changes it undergoes. 102029-44-7. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology.102029-44-7, Name is (R)-4-Benzyl-2-oxazolidinone, molecular formula is C10H11NO2, introducing its new discovery.
Design, synthesis and biological evaluation of substituted (+)-SG-1 derivatives as novel anti-HIV agents
SG-1 was previously identified as a potent Non-nucleoside reverse transcriptase inhibitors (NNRTI) which works through inhibition of reverse transcriptase (RT) RNA-dependent DNA polymerase activity via a direct binding event. To further investigate the relationship between its structure and activity, four series of novel analogues were designed and synthesized with 12 of them inhibiting HIV-1 replication with IC50s in the range 0.09?6.71 muM. Compound 4b, 4c, 4f, 2 and 6b were further tested on two NNRTI-resistant HIV-1 strains and one NNRTI-resistant superbug. The result showed that RT- E138K/M184V mutant virus conferred 4.7?9.1-fold resistance to 4c, 4f, 2 and 6b, but only showed slight resistance to 4b (2-fold) which was better than SG-1.
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Reference£º
Oxazolidine – Wikipedia,
Oxazolidine | C3H1913NO – PubChem