Structural dependence on the property of chiral stationary phases derived from chitosan bis(arylcarbamate)-(amide)s was written by Feng, Zi-Wei;Qiu, Guo-Song;Mei, Xiao-Meng;Liang, Shuang;Yang, Fei;Huang, Shao-Hua;Chen, Wei;Bai, Zheng-Wu. And the article was included in Carbohydrate Polymers in 2017.Reference of 99395-88-7 This article mentions the following:
The goal of present study was to study the structural dependence of chitosan derivatives on enantioseparation and mobile phase tolerance of the corresponding chiral packing materials for liquid chromatog. Hence, a series of chitosan bis(arylcarbamate)-(n-pentyl amide)s and the related chiral stationary phases (CSPs) were prepared from chitosans with different mol. weights Because of the H-bond formed via CH3-π interaction, the CSP bearing Me substituent exhibited higher tolerance than the ones bearing dichloro substituents. The CSP derived from the chitosan bis(3,5-dichlorophenylcarbamate)-(n-pentyl amide) with a higher mol. weight possessed high tolerance to mobile phases, whereas the enantioseparation capability of this CSP was not as good as that of the one prepared from the chitosan derivative with a lower mol. weight Therefore, enantioseparation capability and mobile phase tolerance have to be counterbalanced in designing chiral selectors for the CSPs derived from chitosan bis(arylcarbamate)-(amide)s. In the experiment, the researchers used many compounds, for example, (S)-4-Phenyloxazolidin-2-one (cas: 99395-88-7Reference of 99395-88-7).
(S)-4-Phenyloxazolidin-2-one (cas: 99395-88-7) belongs to oxazolidine derivatives. Oxazolidines that are the precursor to bisoxazolidines are in effect mono-oxazolidines. They are also used as moisture scavengers in polyurethane and other systems. Oxazolidines are cyclic condensation products of β-amino alcohols and aldehydes or ketone, and they undergo a facile and complete hydrolysis in aqueous solution. Alterations in carbonyl moiety control the rate of formation of a given β-amino alcohol.Reference of 99395-88-7
Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem