Electric Literature of 444335-16-4, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Patent, and a compound is mentioned, 444335-16-4, (R)-3-(4-Bromo-3-fluorophenyl)-5-(hydroxymethyl)oxazolidin-2-one, introducing its new discovery.
A reddy handkerchief Wei preparation method and reddy handkerchief Wei intermediates (by machine translation)
The invention provides a method for the preparation of key intermediate reddy handkerchief Wei, to structure shown in the formula I compound and 2 – bromo – 7 – chloro – 9H – wuwu is initiator, to respectively obtain the structure shown as formula II compound and 2 – bromo – 7 – chloro – 9, 9 – difluoro – 9H – fluorene, through carbon – hydrogen activated coupling reaction, Suzuki coupling reaction and deprotecting reaction, to obtain the synthesis of the key intermediate reddy handkerchief Wei ? structure shown in formula VIII compound, key intermediate with the Moc – L – valine condensation reaction, can get reddy handkerchief Wei. The present invention provides the key intermediate reddy handkerchief Wei preparation method is simple, few steps, the key compound 2 – bromo – 7 – chloro – 9, 9 – difluoro – 9H – fluorene (type IV) only three-step reaction in the preparation can be obtained reddy handkerchief Wei key intermediate VIII, improves the utilization rate of the fluorine compound, the preparation cost is reduced. (by machine translation)
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Electric Literature of 444335-16-4. In my other articles, you can also check out more blogs about 444335-16-4
Reference：
Oxazolidine – Wikipedia,
Oxazolidine | C3H2684NO – PubChem