95715-86-9, Name is Methyl (R)-N-Boc-2,2-dimethyloxazolidine-4-carboxylate, belongs to oxazolidine compound, is a common compound. Safety of Methyl (R)-N-Boc-2,2-dimethyloxazolidine-4-carboxylateIn an article, once mentioned the new application about 95715-86-9.
2-Thiazolyl alpha-amino ketones: A new class of reactive intermediates for the stereocontrolled synthesis of unusual amino acids
The thiazole-based one carbon homologation of four alpha-amino acids (L-phenylalanine, L-leucine, L-threonine, and L-serine) to the corresponding alpha-hydroxy beta-amino aldehydes and acids in both configurations at C(alpha), is described. The methodology involves the following key operations: (i) the conversion of an alpha-amino ester to a 2-thiazolyl alpha-amino ketone; (ii) the stereocontrolled reduction of a ketone carbonyl to either syn or anti alpha,beta-amino alcohols; (iii) the aldehyde release from the thiazole ring; (iv) the oxidation of the aldehyde to a carboxylic acid. The methodology was only partially applied to L-phenylglycine because of some limitations in operation (i).
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Reference£º
Oxazolidine – Wikipedia,
Oxazolidine | C3H2509NO – PubChem