Electric Literature of 39657-45-9, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 39657-45-9, Name is Isoxazolidine hydrochloride, molecular formula is C3H8ClNO. In a Article£¬once mentioned of 39657-45-9
A novel linking-protecting group strategy for solid-phase organic chemistry with configurationally stable alpha-[N-(phenylfluorenyl)]amino carbonyl compounds: Synthesis of enantiopure norephedrines on solid support
A novel linking strategy has been developed for synthesizing configurationally stable alpha-amino aldehyde on polymeric supports. Alkylation of L-alanine methyl ester with 9-bromo-9-p-bromophenylfluorenene, followed by ester hydrolysis and coupling to isoxazolidine, provided N-(9-p- bromophenylfluoren-9-yl)alanine isoxazolidide (5), which was transformed into its corresponding boronate 2 by a palladium-catalyzed cross-coupling reaction with diboron pinacol ester. Boronate 2 was anchored to four different polymeric aryl halides 6-9 in 70-99% yields. Polymer-bound alaninal 1b was then synthesized on non-cross-linked polystyrene by hydride reduction of isoxazolidide 10b. Treatment of alaninal 1b with phenylmagnesium bromide, cleavage of the resulting amino alcohol in a 1:2:2 TFA/CH2Cl2/anisole cocktail, and acylation with di-tert-butyl dicarbonate furnished N- (BOC)norephedrines 14 that were demonstrated to be enantiopure by conversion to diastereomeric thioureas 15 and analysis by HPLC. In summary, we have developed a process by which the 9-phenylfluoren-9-yl protecting group has been converted into a new linker for the solid-phase synthesis and manipulation of alpha-amino carbonyl compounds.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Electric Literature of 39657-45-9. In my other articles, you can also check out more blogs about 39657-45-9
Reference£º
Oxazolidine – Wikipedia,
Oxazolidine | C3H1285NO – PubChem