One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, category: oxazolidine, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 102029-44-7, Name is (R)-4-Benzyl-2-oxazolidinone, molecular formula is C10H11NO2
Thromboxane Receptor Antagonism Combined with Thromboxane Synthase Inhibition. 5. Synthesis and Evaluation of Enantiomers of 8-<<(4-Chlorophenyl)sulfonyl>amino>-4-(3-pyridinylalkyl)octanoic Acid
The enantiomers of 8-<<(4-chlorophenyl)sulfonyl>amino>-4-(3-pyridinylpropyl)octanoic acid (1) and its pyridinyl ether analog (2) were synthesized using the highly diastereoselective method of alkylation of acyloxazolidinone.These enantiomerically pure compounds were compared with the corresponding racemic compounds 1 and 2 for their in vitro activity.Compounds 1, 1R, and 1S and 2, 2S, and 2R were equipotent as thromboxane receptor antagonists (TxRAS) and thromboxane synthase inhibitors (TxSIs) (IC50 = 2-30 nM).Upon oral administration to guinea pigs, the enantiomers inhibited the ex vivo U 46619-induced platelet aggregation with potency similar to that of the corresponding racemic compound.This indicates that the enantiomers have pharmacologic profile and bioavailability similar to that of tha corresponding racemic compound.
One of the oldest and most widely used commercial enzyme inhibitors is aspirin, category: oxazolidine, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 102029-44-7
Reference£º
Oxazolidine – Wikipedia,
Oxazolidine | C3H1734NO – PubChem