99395-88-7, (S)-4-Phenyloxazolidin-2-one is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Step 1 : To a 1 liter flask were added 39.21 grams (0.116 mol) compound L-1 (Z configuration), 300 ml of tetrahydrofuran and 19.0 ml (0.14ml) of isobutyl chloroformate. Then, 19.3 ml (0.14mmol) of triethylamine was added dropwise therein at a temperature of about -60C. After the addition, the mixture was warmed up to room temperature and the reaction lasted 30 minutes. The residue was filtered to obtain the mixed anhydride in tetrahydrofuran solution for further use. Step 2: To a 3 liter flask were added 22.69 grams (0.14ml) (S)-4-phenyl-2-oxazolidone and 0.6 liter of tetrahydrofuran . Then, 69.6 ml (2mol/L) of sodium bis(trimethylsilyl)amide was added dropwise therein at about -25C. The reaction lasted 30 minutes. Then, the tetrahydrofuran solution of mixed anhydride obtained from step 1 was added dropwise therein. After the addition, the mixture was warmed up to room temperature and the reaction lasted 1 hour. The residue was extracted 3 times with ethyl acetate (150 mlx3). The organic phases were combined, washed 3 times with brine, dried over anhydrous sodium sulfate and concentrated till dry to obtain 47.62 grams (0.10 mol) of compound III-1 (Z configuration), with the yield of 85%. 1H NMR (400 MHz, CDCl3) : delta 0.05 (s, 6 H, 2¡Á-CH3), 0.86 (s, 9 H, 3¡Á-CH3), 2.59-2.64 (m, 2 H, -CH2-), 3.13-3.18 (m, 2 H, -CH2-), 4.32-4.35 (m, 1 H, -CH2-), 4.52 (s, 2 H, -CH2-), 4.74 (t, 1 H, J = 8.8 Hz, -CH2-), 5.47-5.49 (m, 1 H, -CH-), 5.74 (t, 1 H, J = 7.5 Hz, -CH-), 6.99-7.03 (m, 2 H, Cpr-H), 7.31-7.41 (m, 7 H, Cpr-H); MS (m/z): 506 [M+Na]., 99395-88-7
As the paragraph descriping shows that 99395-88-7 is playing an increasingly important role.
Reference£º
Patent; Zhejiang Hisun Pharmaceutical Co. Ltd.; EP2465847; (2012); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem