95530-58-8,95530-58-8, (R)-4-Isopropyloxazolidin-2-one is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A mixture of (R)-4-isopropyl-oxazolidin-2-one (1.3g, 10 mmol) and NaH (480 mg, 60% oildispersion, 12 mmol) in THF (50 ml) was stirred at rt for 2h. then cooled to 0C. A solution ofbromoacetonitrile (1.4 ml, 20 mmol) in THF (30 ml) was added slowly to the reaction mixture. Theresulting mixture was stirred at rt for overnight. The mixture was treated with small amount of waterand then the mixture was passed through a silica pad. The filtrate was concentrated and the residue20 was subjected to a short column to give the crude product. The process was repeated and bothcrude product were combined and further purified by another short column to give the product(3.3g).To a solution of above product (3.3g, 19 mmol) in THF (40 ml) at ooc was added a solution ofBH3THF in THF (1M, 200 ml). The resulting mixture was stirred at ooc for 30 min. then at rt for 4h.25 The mixture was then cooled to ooc again and treated with cold HCI (6 N, 20 ml) to strong acidic pH.The organic solvent was removed under reduced pressure. The residue was treated with NaOH (4 N,-40 ml) to pH>10, then extracted with EtOAc (5 x 80 ml) and DCM (5 x 80 ml). The combined extracts from both solvent were dried (Na2S04) and concentrated. EtOAc concentrate afford 1.9 gdesired product (not clean) and 650 mg of cleaner product was obtained from the DCM concentrate.A mixture of above product (1.9 g, 11 mmol), 3-bromo-6-fluoro-imidazo[1,2-b]pyridazine (650mg, 3 mmol), and triethylamine (1.5 ml) in isopropyl alcohol (8 ml) was heated in a microwave at5 140C for 20 min. twice. The reaction mixture was concentrated and the residue was subjected toISCO (40 g column), to gave the titled compound (345 mg). LRMS (ESI) mjz 368 and 370.2 [(M+H)]+,calc’d for C14H1sBrN502: 368.24.B
As the paragraph descriping shows that 95530-58-8 is playing an increasingly important role.
Reference£º
Patent; LEXICON PHARMACEUTICALS, INC.; BI, Yingzhi; CARSON, Kenneth Gordon; CIANCHETTA, Giovanni; GREEN, Michael Alan; KUMI, Godwin; LIANG, Zhi; LIU, Ying Jade; MAIN, Alan; ZHANG, Yulian; ZIPP, Glenn Gregory; WO2013/134219; (2013); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem