90719-32-7,90719-32-7, (S)-4-Benzyloxazolidin-2-one is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Commercially available compound 24a (800 mg, 4.5 mmol) was dissolved in anhydrous THF (30 mL) in dry glassware under N2, and cooled to -78 C in a dry ice/acetone bath. A solution of 1.6 M n-butyllithium in hexanes (5.0 mmol, 3.1 mL) was syringed in over 3 min. After mixing for 30 min, propionyl chloride (5.0 mmol, 0.43 mL) was syringed in over 3 min. The solution was allowed to slowly warm to room temperature over 14 h and quenched by the addition of saturated NH4Cl (10 mL) and H2O (30 mL). The final aqueous layer was extracted with ethyl acetate (3 ¡Á 40 mL) and the combined organic extracts were dried over MgSO4 and concentrated in vacuo to yield 25a (oil, 1.0 g, 96% yield) which was >95% pure by HPLC. 1H NMR (500 MHz, CDCl3): delta 7.33 (dd, J1 = 7.4 Hz, J2 = 7.6 Hz, 2H), 7.29 (d, J = 6.9 Hz, 1H), 7.21 (d, J = 7.4 Hz, 2H), 4.67 (m, 1H), 4.18 (m, 2H), 3.31 (dd, J1 = 13.3 Hz, J2 = 3.2 Hz, 1H), 2.96 (m, 2H), 2.77 (dd, J1 = 13.3 Hz, J2 = 3.7 Hz, 1H), 1.21 (t, J = 7.4 Hz, 3H).
As the paragraph descriping shows that 90719-32-7 is playing an increasingly important role.
Reference£º
Article; Girnys, Elizabeth A.; Porter, Vanessa R.; Mosberg, Henry I.; Bioorganic and Medicinal Chemistry; vol. 19; 24; (2011); p. 7425 – 7434;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem