Downstream synthetic route of 2346-26-1

As the paragraph descriping shows that 2346-26-1 is playing an increasingly important role.

2346-26-1, Oxazolidine-2,4-dione is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

C. 4-[4-(2,4-Dioxo-oxazolidin-5-ylidenemethyl)-2-methoxy-phenoxy]-naphthalene-1 – carboxylic acid methyl ester; . A mixture of 4-(4-Formyl-2-methoxy-phenoxy)- naphthalene-1 -carboxylic acid methyl ester (33.6 mg, 0.10 mmol), thiazolidine- 2,4-dione (14.3 mg, 0.11 mmol), sodium acetate (24.6 mg, 0.30 mmol), piperidine (1 drop) and ethanol (2 ml_) /acetonitrile (4 ml_) was heated at reflux overnight. The solvent was evaporated to ~ 2 ml_ volume. After cooling to room temperature, the precipitate was collected by filtration and washed with acetonitrile and water. 1H NMR (400 Hz, DMSO-c/6) ?8.91 (d, 1 H), 8.40 (d, 1 H), 8.08 (d, 1 H), 7.73 (t, 1 H), 7.65 (t, 1 H), 7.4 (d, 1 H), 7.35 (s, 1 H), 7.28 (d, 1 H), 7.21 (d, 1 H), 6.60 (d, 1 H), 3.87 (s, 3H), 3.73 (s, 3H); LC/MS (m/z) [M+1]+ 436.3 (calculated for C23Hi8NO6S, 436.1 ).

As the paragraph descriping shows that 2346-26-1 is playing an increasingly important role.

Reference£º
Patent; JANSSEN PHARMACEUTICA N.V.; WO2008/109727; (2008); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem