16251-45-9, (4S,5R)-4-Methyl-5-phenyloxazolidin-2-one is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
EXAMPLE 38 [4S-(4alpha,5alpha)]3-(3-Furan-2-yl-propionyl)-4-methyl-5-phenyl-oxazoldin-2-one Compound 29 (11.66 g, 83.19 mmol) was dissolved in THF (190 ML) and cooled in an ice bath.. triethyl amine (43.5 ML, 312.1 mmol) was added, followed by the trimethylacetyl chloride (15.4 ML, 125.0 mmol).. The reaction was stirred at 0 C. for 2 hours, and the LiCl (3.879 g, 91.5 mmol), (4S,5R)-(-)-4-methyl-5-phenyl-2-oxazolidinone (15.02 g, 84.76 mmol), and THF (70 ML) were added.. The reaction was stirred at room temperature overnight.. The solids were filtered, washed with EtOAc, and the filtrate and washings rotovapped to give a brown colored suspension.. The solids were filtered, washed with EtOAc, and the filtrated rotovapped.. The crude material was chromatographed on silica eluding with 10% EtOAc/hexanes to give the title compound 38 (19.967 g, 80%) as an off-white solid. 1H NMR (400 MHz, CDCl3) delta7.42-7.33 (m, 3H), 7.29-7.24 (m, 3H), 6.26 (m, 1H), 6.04 (d, 1H, J=3.17), 5.65 (d, 1H, J=7.33 Hz), 4.74 (q, 1H, J=6.8 Hz), 3.35-3.21 (m, 2H, 3.01 (t, 2H, J=7.4 Hz), 0.87 (d, 3H, J=6.59 Hz). MS (APCI) m/z 300 (M++1). Analysis calculated for C17H17NO4: C, 68.22; H, 5.72; N, 4.68. Found: C, 68.34; H, 5.81; N, 4.63. [alpha]D=-39.5 (c=1 in CHCl3).
16251-45-9, As the paragraph descriping shows that 16251-45-9 is playing an increasingly important role.
Reference£º
Patent; Warner-Lambert Company; US6710190; (2004); B1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem