139009-66-8, (S)-N-Boc-2,2-dimethyloxazolidine-4-carboxylic Acid is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
4-Bromobenzene-1,2-diamine (500 mg, 2.67 mmol), (S)-3-(tert-butoxycarbonyl)-2,2-dimethyloxazolidine-4-carboxylic acid ( 656 mg, 2067 mmol) and TEA (1.08 g, 10.7 mmol, 1.49 mL) were dissolved in 8 mL of dioxane. To the homogeneous, dark colored solution was added T3P (3.40 g, 5.35 mmol) and the reaction was stirred at rt overnight. The reaction mixture was concentrated to dryness. The residue was partitioned between 5ml of water and 5 mL of DCM and passed through a phase separation column. The combined organics were again washed with 5 ml of H2O and concentrated to dryness. The residue was suspended in 3 mL of acetic acid and heated at 80C for 2.5 h. The reaction was concentrated under reduced pressure and the residue was partitioned between 8ml of aq. NaHCO3 and CH2Cl2 through a phase separation column. The combined organics were concentrated to yield a dark oil. This was purified using a 40g silica gel column (0 to 50% ethyl acetate in heptane) to provide 687mg (65%) product as a semisolid. MS (AP+) m/z 398 [M+H]+
139009-66-8, As the paragraph descriping shows that 139009-66-8 is playing an increasingly important role.
Reference£º
Article; Brown, Alan D.; Bagal, Sharan K.; Blackwell, Paul; Blakemore, David C.; Brown, Bruce; Bungay, Peter J.; Corless, Martin; Crawforth, James; Fengas, David; Fenwick, David R.; Gray, Victoria; Kemp, Mark; Klute, Wolfgang; Malet Sanz, Laia; Miller, Duncan; Murata, Yoshihisa; Payne, C. Elizabeth; Skerratt, Sarah; Stevens, Edward B.; Warmus, Joseph S.; Bioorganic and Medicinal Chemistry; vol. 27; 1; (2019); p. 230 – 239;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem