13590-42-6, (S)-Benzyl 2-(2,5-dioxooxazolidin-4-yl)acetate is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
At -25 & lt; 0 & gt; C,2.5 g (10.0 mmol) of Intermediate II was dissolved in 30 mL of dry tetrahydrofuran,1.3 eq of methyl chloroformate was added dropwise,1.5 eq of N-methylmorpholine (NMM) was dissolved in 5 mL of tetrahydrofuran and added dropwise to the reaction system over 15 minutes,Stirred at -25 & lt; 0 & gt; C for 1 h,Then warmed to room temperature and stirred overnight.The reaction system was allowed to cool to -25 C,Was acidified with a 4.0 M solution of HCl dioxane,Until the pH of the solution is close to 3.The reaction solution was allowed to warm to room temperature.Under nitrogen protection,The reaction solution was passed through a dry 521 type diatomaceous earth (3.0 g) and treated with tetrahydrofuran as a mobile phase (2 x 5.0 mL)The N-methylmorpholine (NMM) hydrochloride precipitate was removed by filtration.After the filtrate was concentrated,Using TBME / THF / hexanes as solvent,The crystals were recrystallized overnight at -20 C.The solid was collected and stored in a vacuum drier (88% yield).
13590-42-6, As the paragraph descriping shows that 13590-42-6 is playing an increasingly important role.
Reference£º
Patent; Guizhou University; Liu Xiongli; Tian Minyi; Yao Zhen; Liu Xiongwei; Zhang Min; Zhou Ying; Feng Tingting; Yu Zhangbiao; (6 pag.)CN107129501; (2017); A;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem