1121-83-1, 5,5-Dimethyloxazolidin-2-one is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A suspension of 1- (2-fluoro-4-iodophenyl) -5-methoxy-3- (1- phenyl-lH-pyrazol-5-yl) pyridazin-4 (1H) -one (244 mg, 0.500 mmol), 5, 5-dimethyl-l, 3-oxazolidin-2-one (69.1 mg, 0.600 mmol) , trans- 1, 2-diaminocyclohexane (0.012 mL, 0.100 mmol), Cul (9.5 mg, 0.050 mmol), and K3P04 (212 mg, 1.00 mmol) in 1,4-dioxane (2.0 mL) was stirred at 110C under Ar atmosphere. The reaction mixture was poured into 5% NaHC03 aqueous solution (20 mL) and extracted with AcOEt (20 mL x 3) . The combined organic phase was washed with brine (40 mL) , dried with MgS04, and evaporated. The residue was purified by basic silica gel column chromatography (MeOH/AcOEt = 0%-10%) to give the title compound (157.4 mg, 66% yield): ? NMR (300 MHz, DMSO-d6) : delta ppm 1.49 (6H, s) , 3.78 (3H, s), 3.89 (2H, s), 6.97 (1H, d, J = 1.9 Hz), 7.05 (1H, t, J = 9.0 Hz), 7.31 (1H, d, J = 8.7 Hz), 7.31 (1H, t, J = 1.7 Hz), 7.33 (1H, s), 7.37-7.48 (3H, m) , 7.68 (1H, dd, J = 13.4, 2.5 Hz), 7.79 (1H, d, J = 1.9 Hz), 8.46 (1H, d, J = 2.3 Hz). LC-MS (ESI) m/z 476 [M + H]+. Anal. Calcd for C25H22FN5O4 : C, 63.15; H, 4.66; N, 14.73. Found: C, 63.09; H, 4.70; N, 14.85.
1121-83-1, As the paragraph descriping shows that 1121-83-1 is playing an increasingly important role.
Reference£º
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; TANIGUCHI, Takahiko; MIURA, Shotaro; HASUI, Tomoaki; HALLDIN, Christer; STEPANOV, Vladimir; TAKANO, Akihiro; WO2013/27845; (2013); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem