Synthesis and biological evaluation of 2-oxazoline and salicylic acid derivatives was written by Djurendic, Evgenija; Dojcinovic Vujaskovic, Sanja; Sakac, Marija; Ajdukovic, Jovana; Gakovic, Andrea; Kojic, Vesna; Bogdanovic, Gordana; Klisuric, Olivera; Penov Gasi, Katarina. And the article was included in ARKIVOC (Gainesville, FL, United States) in 2011.Synthetic Route of C11H13NO2 The following contents are mentioned in the article:
Starting from Me salicylate and 2-amino-2-(hydroxymethyl)propane-1,3-diol, or 2-amino-2-methylpropane-1-ol, the 2-oxazoline derivatives of salicylic acid were synthesized. Reactions were performed by microwave irradiation in the presence of tetrabutylammonium bromide or metallic sodium as catalyst, as well as by conventional heating. Microwave-induced reaction of some diols, diamines and amino alcs. with Me salicylate gave mono- and/or bis- derivatives of salicylic acid. The mono- and bis-salicyloyl derivatives were transformed to the corresponding phenyl-azo derivatives The structure of one of the synthesized compound was proved by the X-ray anal. and the R-configuration on its stereocenter was confirmed. The antioxidant and cytotoxic activities of the synthesized derivatives were evaluated in a series of in vitro tests. Some of the compounds e,g., I, exhibited very strong activity against hydroxyl radical. Six tested compounds inhibited growth of MDA-MB-231 cells at a nanomolar concentration Two of the compounds e.g., II, showed high cytotoxicity against MCF7 cells, whereas four of the compounds showed high activity against K562 cells. This study involved multiple reactions and reactants, such as 2-(4,4-Dimethyl-4,5-dihydrooxazol-2-yl)phenol (cas: 163165-91-1Synthetic Route of C11H13NO2).
2-(4,4-Dimethyl-4,5-dihydrooxazol-2-yl)phenol (cas: 163165-91-1) belongs to oxazolidine derivatives. Oxazolidine-based compounds have started to attract attention also in the medicinal and materials chemistry fields. Chiral oxazolidines are widely used as chiral auxiliaries, chiral ligands, protecting and/or directing groups in a variety of asymmetric transformations, thanks also to their easy cleavage or their further elaboration possibilities.Synthetic Route of C11H13NO2
163165-91-1;2-(4,4-Dimethyl-4,5-dihydrooxazol-2-yl)phenol;The future of 163165-91-1;New trend of C11H13NO2;function of 163165-91-1