Discovery of (R)-4-Benzyl-3-(3-methylbutanoyl)oxazolidin-2-one

Future efforts will undeniably focus on the diversification of the new catalytic transformations. These may comprise an expansion of the substrate scope from aromatic and heteroaromatic compounds to other hydrocarbons. Keep reading other articles of 145589-03-3. Synthetic Route of 145589-03-3

Synthetic Route of 145589-03-3, Chemical research careers are more diverse than they might first appear, as there are many different reasons to conduct research and many possible environments.

With the aim to address an undesired cardiac issue observed with our related compound in the recently disclosed novel series of renin inhibitors, further chemical modifications of this series were performed. Extensive structure-activity relationships studies as well as in vivo cardiac studies using the electrophysiology rat model led to the discovery of clinical candidate trans-adamantan-1-ol analogue 56 (DS-8108b) as a potent renin inhibitor with reduced potential cardiac risk. Oral administration of single doses of 3 and 10 mg/kg of 56 in cynomolgus monkeys pre-treated with furosemide led to significant reduction of mean arterial blood pressure for more than 12 h.

Future efforts will undeniably focus on the diversification of the new catalytic transformations. These may comprise an expansion of the substrate scope from aromatic and heteroaromatic compounds to other hydrocarbons. Keep reading other articles of 145589-03-3. Synthetic Route of 145589-03-3

Reference：
Oxazolidine – Wikipedia,
Oxazolidine | C3H2606NO – PubChem