Application of 102029-44-7, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 102029-44-7, (R)-4-Benzyl-2-oxazolidinone, introducing its new discovery.
Total synthesis of a hemiacetal polypropionate from Siphonaria australis
A highly stereocontrolled synthesis of (2S,3R,5R,6S)-6-[(1E,3R)-1,3- dimethylhex-1-enyl]-2-ethyl-2-hydroxy-3,5-dimethyltetrahydro-4H-pyran-4-one has been achieved in 13 steps and an overall yield of 7.6% from (A)-(+)-4- benzyloxazolidin-2-one. This substrate-controlled asymmetric synthesis utilized Paterson’s lactate-derived chiral ketone (2S)-2-(benzoyloxy) pentan-3-one to generate the 5R and 6S stereocentres and alkylation of an Evans’ auxiliary to generate the remote side-chain 3R stereocentre. Furthermore, a novel, highly efficient, and selective strategy was used to generate an enol trimethylsilyl ether whose subsequent Mukaiyama aldol condensation gave the acyclic precursor to the final product. A thermodynamically controlled cyclization then gave (2S,3R,5R,6S)-6-[(1E,3R)-1,3-dimethylhex-1-enyl]-2-ethyl-2-hydroxy-3, 5-dimethyltetrahydro-4H-pyran-4-one with control of the 2S and 3R stereocentres. The NMR spectroscopic data and optical rotation obtained for synthetic (2S,3R,5R,6S)-6-[(1E,3R)-1,3-dimethylhex-1-enyl]-2-ethyl-2-hydroxy-3, 5-dimethyltetrahydro-4H-pyran-4-one were consistent with those reported forthe hemiacetal isolated from Siphonaria australis, and thus, prove the absolute and relative configuration of the natural product.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Application of 102029-44-7. In my other articles, you can also check out more blogs about 102029-44-7
Reference£º
Oxazolidine – Wikipedia,
Oxazolidine | C3H1912NO – PubChem