39657-45-9, Name is Isoxazolidine hydrochloride, belongs to oxazolidine compound, is a common compound. Product Details of 39657-45-9In an article, once mentioned the new application about 39657-45-9.
Chirospecific Syntheses of Nitrogen and Side-Chain Modified Anatoxin Analogues. Synthesis of (1R)-Anatoxinal and (1R)-Anatoxinic Acid Derivatives
A straightforward and good yielding route to side-chain analogues of the potent neurotoxin and neurotransmitter (+)-anatoxin (1) has been developed.Peroxy acid oxidation of the (silyloxy)butadiene 43 derived from readily synthesized, optically pure (1R)-t-BOC-anatoxin (42) affords silyloxy ketone 44.Fluorolysis of 44 followed by oxidative cleavage of the resultant alpha-hydroxy ketone 45 gives a mixture of alpha,beta-unsaturated acid 46 and ester 41 in 57percent combined yield.Other approaches to these compounds, based on literature precedent, failed. (1R)-t-BOC-anatoxinic acid (46) then serves as educt for the synthesis of a wide variety of anatoxin derivatives with modified side-chain functionality.These analogues, designed to serve as probes of the antagonist binding site of the nicotinic acetylcholine receptor, include alcohol, aldehyde, amide, hydroxamate, and oxime ether functional groups.
Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 39657-45-9
Reference£º
Oxazolidine – Wikipedia,
Oxazolidine | C3H1288NO – PubChem