Safety of 2,6-Dichloropurine. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 2,6-Dichloropurine, is researched, Molecular C5H2Cl2N4, CAS is 5451-40-1, about Synthesis and anticancer activity of N-9- and N-7- substituted 1,2,3 triazole analogues of 2,6-di-substituted purine.
A library of N-9- and N-7-substituted 1,2,3 triazole analogs I [R1 = 2-hydroxyethylamino, benzylamino; R2 = pyrrolidin-1-yl, 1-piperidyl; R3 = H, 4-F, 2-Cl, etc.] and II [R4 = benzylamino; R5 = pyrrolidin-1-yl, 1-piperidyl; R6 = 4-MeO, 4-Br, 4-I] were generated on the 2,6-di-substituted purine upon reaction with various substituted aromatic azides. The synthesized analogs I and II were screened for in-vitro cytotoxic activity against various human cancer cell lines like (HCT-1 (colon), THP-1 (leukemia), IMR-32 (neuroblastoma) and A-549 (lung)). From the bioassay results, it was observed that even though most of the synthesized derivatives I and II exhibited a good potency against various screened cancer cell lines, but few of the analogs like I [R1 = benzylamino; R2 = pyrrolidin-1-yl, 1-piperidyl; R3 = H] and compound I [R1 = benzylamino; R2 = pyrrolidin-1-yl, R3 = 4-Cl] were found to be the most potent analogs in the series, with compound I [R1 = benzylamino, R2 = pyrrolidin-1-yl, R3 = H] showing IC50 values of 0.08 and 0.4 μM against THP-1 and A-549 cell lines, resp.
The article 《Synthesis and anticancer activity of N-9- and N-7- substituted 1,2,3 triazole analogues of 2,6-di-substituted purine》 also mentions many details about this compound(5451-40-1)Safety of 2,6-Dichloropurine, you can pay attention to it, because details determine success or failure
Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem