Electric Literature of 497-25-6, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 497-25-6, Name is Oxazolidin-2-one,introducing its new discovery.
The alkylation reactions of enolates derived from the highly diastereoselective conjugate additions of lithium (R)-N-benzyl-N-alpha-methylbenzylamide (R)-1 to N,N-dimethyl crotonamide 2 and N,N-dimethyl cinnamide 3 have been investigated.The alkylations of enolates derived from 3 are shown to afford anti-alpha-alkyl-beta-amino carboxamides with excellent stereocontrol: the stereochemistry is assigned with the aid of a single crystal X-ray structure of (2R,3S,alphaR)-N,N-dimethyl-2-benzyl-3-phenyl-3-(N-benzyl-N-alpha-methylbenzylamino)propanamide (2R,3S,alphaR)-10.As a result of the difficulty encountered is hydrolysing these hindered beta-amino amides such as 10, an alternative procedure is developed involving conjugate addition-alkylations with alpha,beta-unsaturated N-acyloxazolidin-2-ones as substrates, giving selectively alkylated products which are susceptible to reductive cleavage.
We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 497-25-6, and how the biochemistry of the body works.Electric Literature of 497-25-6
Reference：
Oxazolidine – Wikipedia,
Oxazolidine | C3H475NO – PubChem