The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: Oxazole(SMILESS: O1C=NC=C1,cas:288-42-6) is researched.Safety of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone. The article 《PO-322 exerts potent immunosuppressive effects in vitro and in vivo by selectively inhibiting SGK1 activity》 in relation to this compound, is published in British Journal of Pharmacology. Let’s take a look at the latest research on this compound (cas:288-42-6).
Background and Purpose : Immunosuppressive drugs have shown great promise in treating autoimmune diseases in recent years. A series of novel oxazole derivatives were screened for their immunosuppressive activity. PO-322 [1H-indole-2,3-dione 3-(1,3-benzoxazol-2-ylhydrazone)] was identified as the most effective of these compounds Here, we have investigated the mechanism(s) underlying the inhibition of T-cell proliferation in vitro by PO-322, as well as its effects on the delayed-type hypersensitivity (DTH) response and imiquimod-induced dermatitis in vivo. Exptl. Approach : T-cell proliferation and apoptosis were analyzed with flow cytometry. Cell viability was assessed with a CCK-8 assay. Protein kinase activity was assessed by SelectScreen Kinase Profiling Services. The phosphorylation of signal-regulated mols. was measured by Western blot. The effect of PO-322 on DTH and imiquimod-induced dermatitis was evaluated in BALB/c mice. Key Results : PO-322 inhibited human T-cell proliferation with anti-CD3/anti-CD28 mAbs or alloantigen without significant cytotoxicity. Finally, treatment with PO-322 was safe and effective for ameliorating the DTH response and imiquimod-induced dermatitis in mice. Conclusions and Implications : PO-322 exerted immunosuppressive activity in vitro and in vivo by selectively inhibiting SGK1 activity. PO-322 represents a potential lead compound for the design and development of new drugs for the treatment of autoimmune diseases.
After consulting a lot of data, we found that this compound(288-42-6)Recommanded Product: Oxazole can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem