Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. Application In Synthesis of (S)-1-(4-Fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione. Introducing a new discovery about 189028-93-1, Name is (S)-1-(4-Fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione
The ezetimibe intermediate and its synthetic method and the ezetimibe synthetic method (by machine translation)
The present invention provides intermediates of ezetimibe and its synthetic method and the ezetimibe synthesis method, the method of short synthetic route. The invention uses fluorobenzene as the starting material, fluorophenyl sequentially with glutaric anhydride, 4 (S)- 4 – phenyl oxazolidone acylation occurs after generating II, then 2, 2 – disubstituted – 1, 3 – propylene glycol to carbonyl compound can be obtained by protecting III, then compound III with compound IV in the titanium tetrachloride catalytic produced under the compound V, the compound V the producing the compound VI, the compound VI is hydrolyzed to compound VII, compound VII of compound soluble chiral reducing agent and hydrogenation to remove benzyl protecting group to obtain the ezetimibe. The method has high yield, less side reaction, is suitable for industrial production. (by machine translation)
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Application In Synthesis of (S)-1-(4-Fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione, you can also check out more blogs about189028-93-1
Reference：
Oxazolidine – Wikipedia,
Oxazolidine | C3H2800NO – PubChem