Formulation and evaluation of mouth dissolving film of Zolmitriptan by using natural polymers was written by Daswadkar, Shubhangi;Patil, Shivani B. Sontakke. And the article was included in World Journal of Pharmacy and Pharmaceutical Sciences in 2020.Application of 139264-17-8 This article mentions the following:
Zolmitriptan is a BCS class III generation antimigraine drug that is used for the treatment of migraine and has low metabolism and permeability. This drug also undergoes first-pass metabolism To overcome all these problems mouth dissolving films were prepared which helps to improve the bioavailability of drugs. Mouth films dissolve fastly along with drugs and mostly all the drug absorbs through oral mucosa in the systemic circulation. Mouth films were prepared by the solvent casting method. Various issues related to drug release and side effects of synthetic polymers, formulating mouth dissolving films of Zolmitriptan utilizing natural polymers was beneficial and effective, and its the main aim of present work. Polymer concentration, Glycerol, and type of polymer i.e. maize starch, pectin and guar gum were optimized by using central composite 3 factors, 2 level design based on drug release, and folding endurance of films. A total of 39 batches were prepared from which batch containing 50% pectin and 20% glycerol, was found to be best with desirability 0.998. Oral films of the optimized batch show 27±2 number of folds and show 98.12±0.1% drug release. The optimized film was further evaluated for drug content uniformity, phys. appearance, solubility, stability, disintegration and dissolution study. In the experiment, the researchers used many compounds, for example, (S)-4-((3-(2-(Dimethylamino)ethyl)-1H-indol-5-yl)methyl)oxazolidin-2-one (cas: 139264-17-8Application of 139264-17-8).
(S)-4-((3-(2-(Dimethylamino)ethyl)-1H-indol-5-yl)methyl)oxazolidin-2-one (cas: 139264-17-8) belongs to oxazolidine derivatives. Oxazolidines are well known as key portions of bioactive molecules or precursors of chiral molecules, as well as established chiral auxiliaries. Chiral oxazolidines are widely used as chiral auxiliaries, chiral ligands, protecting and/or directing groups in a variety of asymmetric transformations, thanks also to their easy cleavage or their further elaboration possibilities.Application of 139264-17-8
Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem