Name: 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone, is researched, Molecular C12H16N2O2, CAS is 67914-60-7, about Synthesis and antimicrobial activity of new series of piperazine containing chalcone derivatives. Author is Kumar, J. Ranjith; Nissankararao, Srinath; Ushasri, S.; Rehaman, Sk. A..
Treatment of 1-acetyl-4-(4-hydroxyphenyl)piperazine with aromatic or substituted aromatic aldehydes in presence of methanol and potassium hydroxide, formed 3-substituted phenyl-1-(4-(4-hydroxylphenyl)piperzin-1-yl)-prop-2-en-1-one derivatives I (R = Ph, 4-ClC6H4, 4-FC6H4, etc.). These are assayed for their antibacterial activity against Bacillus pumilus, Bacillus subtilis, Escherichia coli, Proteus vulgaris and for antifungal activity against Aspergillus niger, Candida albicans strains. Antibacterial assay revealed that Bacillus subtilis and Proteus vulgaris were the most sensitive bacterial strains to compounds I (R = 4-ClC6H4, 4-FC6H4, 4-O2NC6H4, 2,4-di-MeOC6H3, 2,4-Cl2C6H3) and in the antifungal assay, compounds I (R = Ph, 4-FC6H4, 2,4-Cl2C6H3) were highly effective against Aspergillus niger when compared to other other investigated strains.
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