Ejaz, Saima; Nadeem, Humaira; Paracha, Rehan Zafar; Sarwar, Sadia; Ejaz, Sadaf published the article 《Designing, synthesis and characterization of 2-aminothiazole-4-carboxylate Schiff bases; antimicrobial evaluation against multidrug resistant strains and molecular docking》. Keywords: Escherichia Staphylococcus Candida aminothiazole antimicrobial mol docking; 2-Aminothiazole; Antifungal activity; Antimicrobial evaluation; Minimum inhibitory concentration; Molecular docking; Schiff bases.They researched the compound: Ethyl 3-bromo-2-oxopropanoate( cas:70-23-5 ).Reference of Ethyl 3-bromo-2-oxopropanoate. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:70-23-5) here.
Background: 2-Aminothiazoles are significant class of organic medicinal compounds utilized as starting material for the synthesis of diverse range of heterocyclic analogs with promising therapeutic roles as antibacterial, antifungal, anti-HIV, antioxidant, antitumor, anthelmintic, anti-inflammatory & analgesic agents. Exptl.: Eight compounds 1a, 2a-2g were synthesized and characterized by FTIR and NMR (1H and 13C). Evaluation of antibacterial potential against multi-drug resistant clin. isolates was performed and min. inhibitory concentration (MIC) values were determined Antifungal activity was also performed. Protein-ligand interactions of compounds with target enzyme were evaluated through docking studies. Results: Resistance profiling of bacterial clin. isolates (MDRs) depicted that some standard drugs used were not active against these MDRs while our synthesized compounds showed good MIC values. Among all the synthesized compounds, 2a and 2b showed significant antibacterial potential towards gram-pos. Staphylococcus epidermidis and gram-neg. Pseudomonas aeruginosa at MIC 250 μg/mL and 375 μg/mL resp. Likewise, compound 2d and 2g exhibited inhibitory potential against gram-pos. Staphylococcus aureus and gram-neg. Escherichia coli at MIC values of 250 and 375 μg/mL resp. Compound 2b showed maximum antifungal potential against Candida glabrata (ATCC 62934) with a zone of inhibition 21.0 mm as compared to the reference drug nystatin which showed lesser antifungal potential with a zone of inhibition of 19.1 mm. Candida albicans (ATCC 60387) showed maximum sensitivity to compound 2a with a zone of inhibition 20.0 mm. Its antifungal activity is more in comparison to reference drug nystatin with exhibited the zone of inhibition of 19.3 mm. Designed compounds were docked with the target enzyme UDP-N-acetylmuramate/L-alanine ligase. The compound 2b showed highest binding affinity (- 7.6 kcal/mol). Conclusions: The synthesized compounds showed moderate to significant antibacterial and antifungal potential. It is clear from the binding affinities that compounds having hydroxyl group substituted on benzene ring possess strong binding affinity as compared to other analogs. These designed compounds could be considered to act as antagonists against target UDP-N-acetylmuramate/L-alanine ligase.
This literature about this compound(70-23-5)Reference of Ethyl 3-bromo-2-oxopropanoatehas given us a lot of inspiration, and I hope that the research on this compound(Ethyl 3-bromo-2-oxopropanoate) can be further advanced. Maybe we can get more compounds in a similar way.
Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem