Category: oxazolidines

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Mardani, Z., once mentioned the application of 6704-31-0, Name is Oxetan-3-one, molecular formula is C3H4O2, molecular weight is 72.0627, MDL number is MFCD09263255, category is oxazolidines. Now introduce a scientific discovery about this category, COA of Formula: C3H4O2.

Coordination of a (N-py)(2)(NNamine)-N-imine-Donor Oxazolidine Ligand Toward CdX2(X= Cl, Br, I) with 1:1 and 2:1 M:L Molar Ratios Along with Spectral, Theoretical, and Structural Studies

A series of reactions between an oxazolidine ligand 2-(2-(pyridin-2-yl)oxazolidin-3-yl)-N-(pyridin-2-ylmethylene)ethanamine (POPME) and CdX2(X= Cl, Br, I) salts with different M:L molar ratios (1:1 and 2:1) is experimentally studied to determine the most stable product of these reactions. All products are characterized by the elemental analysis, FTIR, Raman, and(1)H NMR spectroscopy, and single crystal X-ray diffraction. Examinations reveal that only one product is formed from 1:1 and 2:1 M:L reactions between each cadmium(II) halide with POPME. The thermodynamic stability and charge distribution patterns of the compound containing bromide are analyzed by DFT and NBO.

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Reference:
Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem

 

Application of 90319-52-1, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 90319-52-1, Name is (R)-4-Phenyloxazolidin-2-one, SMILES is O=C1OC[C@@H](C2=CC=CC=C2)N1, belongs to oxazolidines compound. In a article, author is Ishikawa, Takuya, introduce new discover of the category.

Regioselective Synthesis of Difluoromethylated Oxazolidines and 2-Imidazolines

Difluoromethylated oxazolidines and 2-imidazolines were synthesized regioselectively by the reaction of 2-(difluoromethyl)-1-tosylaziridine with various aldehydes or nitriles in the presence of silver(I) hexafluoroantimonate or titanium(IV) fluoride, respectively.

Application of 90319-52-1, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 90319-52-1 is helpful to your research.

Reference:
Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem

 

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 84793-24-8, Name is Ethyl (S)-2-[(S)-4-Methyl-2,5-dioxo-3-oxazolidinyl]-4-phenylbutanoate, molecular formula is C16H19NO5. In an article, author is Gondela, Andrzej,once mentioned of 84793-24-8, COA of Formula: C16H19NO5.

Convenient Synthesis of Pyrimidine acyclo-2,2 ‘-anhydronucleosides and their Exploitation Toward Selected N-nucleophiles

A new method of the synthesis of 2-(hydroxymethyl-2H-oxazolo[3,2-a]pyrimidin-7(3H)-ones, commonly known as pyrimidine acyclo-2,2′-anhydronucleosides, was developed. Under the Mitsunobu reaction conditions, 5-substituted 1-(3′-alkoxy-2′-hydroxypropyl)uracil derivatives underwent an intramolecular cyclization to the corresponding 2-alkoxymethyl-2,3-dihydro-7H-oxazolo[3,2-a]pyrimidin-7-ones. The various synthetic methods have been demonstrated in the reactions with several N-nucleophiles. Importantly from the mechanistic point of view, in the case of 6-bromo-2-(hydroxymethyl)-2H-oxazolo[3,2-a]pyrimidin-7(3H)-one treated with chiral isocyanate the inversion of configuration at the C-4’ carbon atom accompanied by the oxazolidine ring opening was observed.

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Reference:
Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem

 

Electric Literature of 34052-90-9, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 34052-90-9, Name is 1,3-Bis(4,5-dihydrooxazol-2-yl)benzene, SMILES is C1(C2=NCCO2)=CC=CC(C3=NCCO3)=C1, belongs to oxazolidines compound. In a article, author is Wang, Huan, introduce new discover of the category.

An Efficient and Highly Diastereoselective Synthesis of GSK1265744, a Potent HIV Integrase Inhibitor

A novel synthesis of GSK1265744, a potent HIV integrase inhibitor, is described. The synthesis is highlighted by an efficient construction of the densely functionalized pyridinone core as well as a highly diastereoselective formation of the acyl oxazolidine moiety. The latter exploits the target molecule’s ability to chelate to Mg2+, a key feature in the integrase inhibitor’s mechanism of action.

Electric Literature of 34052-90-9, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 34052-90-9 is helpful to your research.

Reference:
Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem

 

Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 6704-31-0, Name is Oxetan-3-one, SMILES is O1CC(C1)=O, in an article , author is Agerbirk, Niels, once mentioned of 6704-31-0, COA of Formula: C3H4O2.

Glucosinolate turnover in Brassicales species to an oxazolidin-2-one, formed via the 2-thione and without formation of thioamide

Glucosinolates are found in plants of the order Brassicales and hydrolyzed to different breakdown products, particularly after tissue damage. In Barbarea vulgaris R.Br. (Brassicaceae), the dominant glucosinolate in the investigated G-type is glucobarbarin, (S)-2-hydroxy-2-phenylethylglucosinolate. Formation of the nitrile from glucobarbarin was observed in vitro, while a previously suggested thioamide (synonym thionamide) was not confirmed. Resedine (5-phenyl-1,3-oxazolidin-2-one) was detected after glucobarbarin hydrolysis in crushed B. vulgaris leaves and siliques, but not in intact parts. The abundance increased for several hours after completion of hydrolysis. The corresponding 1,3-oxazolidine-2-thione (OAT), with the common name barbarin, was also formed, and appeared to be the precursor of resedine. Addition of each of two non-endogenous OATs, (S)-5-ethyl-5-methylOAT and (R)-5-vinylOAT (R-goitrin), to a leaf homogenate resulted in formation of the corresponding 1,3-oxazolidin-2-ones (OAOs), confirming the metabolic connection of OAT to OAO. Formation of OAOs was inhibited by prior brief heating of the homogenate, suggesting enzyme involvement. We suggest the conversion of OATs to OAOs to be catalyzed by an enzyme (oxazolidinethionase) responsible for turnover of OAT formed in intact plants. Resedine had been reported as an alkaloid from another species – Reseda luteola L. (Resedaceae) – naturally containing the glucosinolate glucobarbarin. However, resedine was not detected in intact R. luteola plants, but formed after tissue damage. The formation of resedine in two families suggests a broad distribution of putative OATases in the Brassicales; potentially involved in glucosinolate turnover that needs myrosinase activity as the committed step. In agreement with the proposed function of OATase, several candidate genes for myrosinases in glucosinolate turnover in intact plants were discovered in the B. vulgaris genome. We also suggest that biotechnological conversion of OATs to OAOs might improve the nutritional value of Brassicales protein. HPLC-MS/MS methods for detection of these glucobarbarin products are described. (C) 2018 Elsevier Ltd. All rights reserved.

Interested yet? Read on for other articles about 6704-31-0, you can contact me at any time and look forward to more communication. COA of Formula: C3H4O2.

Reference:
Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem

 

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 90319-52-1, Name is (R)-4-Phenyloxazolidin-2-one, molecular formula is C9H9NO2, belongs to oxazolidines compound. In a document, author is Wang, Yong, introduce the new discover, Recommanded Product: 90319-52-1.

One-Pot Synthesis of N-Dichloroacetyl-2-methyl-2-phenylethyl-1,3-oxazolidine

N-Dichloroacetyl-2-methyl-2-phenylethyl-1,3-oxazolidine (4) was synthesized through condensation of ethanolamine and 4-phenyl-2-butanone followed by acylation with dichloroacetyl chloride. The orthogonal experiment was employed to investigate the effects of solvent polarity, reaction temperature, stirring time, and molar ratio of reactants on the yield of the title compound. The optimal experimental conditions were as following: Chloroform as solvent, reaction temperature 3-8 degrees C, stirring time 2 h, and the molar ratio of ethanolamine to 4-phenyl-2-butanone 1:1. Under the optimal experimental conditions, the yield of title compound was 81.2%. The proposed synthetic route is simple, the reaction conditions are mild, and the raw materials are cheap and easy to be obtained. [GRAPHICS] .

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 90319-52-1. Recommanded Product: 90319-52-1.

Reference:
Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem

 

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 34052-90-9, Name is 1,3-Bis(4,5-dihydrooxazol-2-yl)benzene, SMILES is C1(C2=NCCO2)=CC=CC(C3=NCCO3)=C1, in an article , author is Yan, Chen, once mentioned of 34052-90-9, Safety of 1,3-Bis(4,5-dihydrooxazol-2-yl)benzene.

Spiramine derivatives induce apoptosis of Bax(-/-)/Bak(-/-) cell and cancer cells

Spiramine C-D, the atisine-type diterpenoid alkaloids isolated from the Chinese herbal medicine Spiraea japonica complex, are shown to have anti-inflammatory effects in vitro. In this study, we report that spiramine derivatives of spiramine C-D bearing alpha,beta-unsaturated ketone induce apoptosis of Bax (/) /Bak (/) MEFs cell, which is positively corresponding their cytotoxicity of tumor cell lines including multidrug resistance MCF-7/ADR. The results indicated that oxazolidine ring is necessary, and derivatives bearing double ‘Michael reaction acceptor’ group would significantly increased activities both of inducing apoptosis of Bax (/) /Bak (/) cells and cytotoxicity of tumor cells. The result indicated that spiramine derivative with alpha,beta-unsaturated ketone group is a new anti-cancer agent with a capability of inducing apoptosis of cancer cells in Bax(-/-)/Bak(-/-) independent manner. (C) 2014 Elsevier Ltd. All rights reserved.

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Reference:
Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem

 

Electric Literature of 84793-24-8, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 84793-24-8, Name is Ethyl (S)-2-[(S)-4-Methyl-2,5-dioxo-3-oxazolidinyl]-4-phenylbutanoate, SMILES is O=C(OCC)[C@@H](N([C@H]1C)C(OC1=O)=O)CCC2=CC=CC=C2, belongs to oxazolidines compound. In a article, author is Wu Yi, introduce new discover of the category.

Synthesis and Biological Evaluation of Amino Alcohol Containing 1,3,4-Oxadiazole

A series of amino alcohol derivatives containing 1,3,4-oxadiazole moieties was synthesized with 7-bromo-2-tetralone as starting materials, 2,2-dimethyl-1,3-oxazolidine as intermediates and Strecker reaction and cyclization with POCl3 as key steps. The structures of the key intermediate and target compounds were confirmed by H-1 NMR, C-13 NMR and HRMS. Some compounds have resulted in the generation of highly potent sphingosine 1-phosphate receptor type 1(S1P(1)) agonists.

Electric Literature of 84793-24-8, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 84793-24-8 is helpful to your research.

Reference:
Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem

 

In an article, author is Movsumzade, M. M., once mentioned the application of 16251-45-9, Formula: C10H11NO2, Name is (4S,5R)-4-Methyl-5-phenyloxazolidin-2-one, molecular formula is C10H11NO2, molecular weight is 177.2, MDL number is MFCD00066226, category is oxazolidines. Now introduce a scientific discovery about this category.

Investigation of Chemical Properties and Antimicrobial Activity of Acetylene Glycidyl Ethers

Reactions of acetylene glycidyl ethers with butylamine and ethylene diamine lead to the oxirane ring opening according to the Krasusky rule with the formation of acetylene aminoalcohols. In reaction with thiourea the oxygen atom in the ring is replaced by sulfur leading to the corresponding thiiranes in a high yield. The synthesized compounds possess high antimicrobial activity.

If you are interested in 16251-45-9, you can contact me at any time and look forward to more communication. Formula: C10H11NO2.

Reference:
Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem

 

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Application In Synthesis of (4S,5R)-4-Methyl-5-phenyloxazolidin-2-one, 16251-45-9, Name is (4S,5R)-4-Methyl-5-phenyloxazolidin-2-one, molecular formula is C10H11NO2, belongs to oxazolidines compound. In a document, author is Fu, Ying, introduce the new discover.

CoMSIA Studyof a Series of N-dichloroacetyl Oxazolidine Derivatives

Comparative molecular similarity indices analysis (CoMSIA) were performed on N-dichloroacetyl oxazolidine derivatives as herbicide safeners. The best CoMSIA models that were generated using atom based alignmen, R-cv(2)=0.632, n=4, R-2=0.927, F=31.796 and s=0.097. The contributions of steric field, electrostatics field, hydrophobicities field and hydrogenbond acceptor were 0.127, 0.260, 0.285 and 0.328, respectively. The CoMSIA model was satisfactory and would be useful for the future design of new N-dichloroacetyl oxazolidine herbicide safener.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 16251-45-9. Application In Synthesis of (4S,5R)-4-Methyl-5-phenyloxazolidin-2-one.

Reference:
Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem