Category: oxazolidine

Tracing coffee origin by direct injection headspace analysis with PTR/SRI-MS was written by Yener, Sine;Romano, Andrea;Cappellin, Luca;Granitto, Pablo M.;Aprea, Eugenio;Navarini, Luciano;Mark, Tilmann D.;Gasperi, Flavia;Biasioli, Franco. And the article was included in Food Research International in 2015.Application of 20662-84-4 This article mentions the following:

The headspace of six roasted Coffea arabica coffees, both brew and powder, of different geog. origins (Brazil, Ethiopia, Guatemala, Costa Rica, Colombia, and India) was analyzed by Proton Transfer Reaction-Time of Flight-Mass Spectrometry. For the first time, in the case of coffee, a Switching Reagent Ion System has been used to produce different ionisation agents: H₃O⁺, NO⁺ and O⁺₂. Significant differences were found among volatile concentrations for the different origins both for powders and brews, in particular high concentrations of terpenes for Ethiopia, sulfur compounds for Colombia and thiazoles for Brazil and India. Effective classification models have been set for the different ionisation modes and data fusion of the data obtained by different reagent ions further reduced the classification errors. In the experiment, the researchers used many compounds, for example, 2,4,5-Trimethyloxazole (cas: 20662-84-4Application of 20662-84-4).

2,4,5-Trimethyloxazole (cas: 20662-84-4) belongs to oxazolidine derivatives. Oxazolidines that are the precursor to bisoxazolidines are in effect mono-oxazolidines. They are also used as moisture scavengers in polyurethane and other systems. Chiral oxazolidines are widely used as chiral auxiliaries, chiral ligands, protecting and/or directing groups in a variety of asymmetric transformations, thanks also to their easy cleavage or their further elaboration possibilities.Application of 20662-84-4

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Polyplex nanomicelle delivery of self-amplifying RNA vaccine was written by Chang, Yi-Hao;Lin, Mei-Wei;Chien, Ming-Chen;Ke, Guan-Ming;Wu, I-En;Lin, Ren-Li;Lin, Chin-Yu;Hu, Yu-Chen. And the article was included in Journal of Controlled Release in 2021.Name: (S)-Benzyl 2-(2,5-dioxooxazolidin-4-yl)acetate This article mentions the following:

Self-amplifying RNA (SaRNA) is a burgeoning platform that exploits the replication machinery of alphaviruses such as Venezuelan equine encephalitis (VEE) virus or Sindbis virus (SIN). SaRNA has been used for development of human vaccines, but has not been evaluated for porcine vaccine development. Porcine reproductive and respiratory syndrome virus (PRRSV) causes tremendous economic losses to the worldwide pork industry, but current vaccines trigger delayed neutralizing antibody response and confer only partial protection. Here we first compared two SaRNA systems based on VEE and SIN, and demonstrated that in vitro transcribed VEE-based SaRNA conferred prolonged reporter gene expression and RNA amplification in pig cells with low cytotoxicity, but SIN-based SaRNA imparted evident cytotoxicity and limited gene expression in pig cells. Transfection of VEE-based SaRNA that encodes the major PRRSV antigen dNGP5 (SaRNA-dNGP5) conferred persistent expression for at least 28 days in pig cells. We next complexed SaRNA-dNGP5 with the polyaspartamide block copolymer PEG-PAsp(TEP) to form polyplex nanomicelle with high packaging efficiency and narrow size distribution. The polyplex nanomicelle enabled sustained dNGP5 expression and secretion in vitro. Compared with the com. PRRS vaccine, nanomicelle delivery of SaRNA-dNGP5 into animal models accelerated the induction of potent neutralizing antibodies with minimal side effects, and elicited stronger IL-4 and IFN-γ responses against homologous and heterologous PRRSV. These properties tackle the problems of current vaccines and implicate the potential of SaRNA-dNGP5 nanomicelle as an effective PRRS vaccine. In the experiment, the researchers used many compounds, for example, (S)-Benzyl 2-(2,5-dioxooxazolidin-4-yl)acetate (cas: 13590-42-6Name: (S)-Benzyl 2-(2,5-dioxooxazolidin-4-yl)acetate).

(S)-Benzyl 2-(2,5-dioxooxazolidin-4-yl)acetate (cas: 13590-42-6) belongs to oxazolidine derivatives. Oxazolidine-based compounds are well-known chiral auxiliaries and strategic molecular moieties in chemistry since they can effectively mask or mimic amino acid units or amino alcohols. In another report, the incorporation of an additional substituted oxazolidine ring over a range of new biphenylazepinium salt organocatalysts for the asymmetric epoxidation of alkenes improved enantiocontrol over the parent structures.Name: (S)-Benzyl 2-(2,5-dioxooxazolidin-4-yl)acetate

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Easy-to-Implement Hydrogen Isotope Exchange for the Labeling of N-Heterocycles, Alkylkamines, Benzylic Scaffolds, and Pharmaceuticals was written by Levernier, Etienne;Tatoueix, Kevin;Garcia-Argote, Sebastien;Pfeifer, Viktor;Kiesling, Ralf;Gravel, Edmond;Feuillastre, Sophie;Pieters, Gregory. And the article was included in JACS Au in 2022.Recommanded Product: 139264-17-8 This article mentions the following:

Facilitating access to deuterated and tritiated complex mols. is of paramount importance due to the fundamental role of isotopically labeled compounds in drug discovery and development. Deuterated analogs of drugs are extensively used as internal standards for quantification purposes or as active pharmaceutical ingredients, whereas tritiated drugs are mandatory for preclin. ADME studies. In this report, we describe the labeling of prevalent substructures in FDA-approved drugs such as azines, indoles, alkylamine moieties or benzylic carbons by the in situ generation of Rh nanoparticles able to catalyze both C(sp²)-H and C(sp³)-H activation processes. In this easy-to-implement labeling process, Rh nanocatalysts are formed by decomposition of a com. available rhodium dimer under a deuterium or tritium gas atm. (1 bar or less), using the substrate itself as a surface ligand to control the aggregation state of the resulting metallic clusters. It is noteworthy that the size of the nanoparticles observed is surprisingly independent of the substrate used and homogeneous, as evidenced by transmission electron microscopy experiments This method has been successfully applied to the one-step synthesis of: (1) deuterated pharmaceuticals useable as internal standards for MS quantification: (2) tritiated drug analogs with very high molar activities (up to 113 Ci/mmol). In the experiment, the researchers used many compounds, for example, (S)-4-((3-(2-(Dimethylamino)ethyl)-1H-indol-5-yl)methyl)oxazolidin-2-one (cas: 139264-17-8Recommanded Product: 139264-17-8).

(S)-4-((3-(2-(Dimethylamino)ethyl)-1H-indol-5-yl)methyl)oxazolidin-2-one (cas: 139264-17-8) belongs to oxazolidine derivatives. Oxazolidines are well known as key portions of bioactive molecules or precursors of chiral molecules, as well as established chiral auxiliaries. Chiral oxazolidines are widely used as chiral auxiliaries, chiral ligands, protecting and/or directing groups in a variety of asymmetric transformations, thanks also to their easy cleavage or their further elaboration possibilities.Recommanded Product: 139264-17-8

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Cost-Effectiveness of Reclassifying Triptans in Australia: Application of an Economic Evaluation Approach to Regulatory Decisions. was written by Parkinson, Bonny;Gumbie, Mutsa;Cutler, Henry;Gauld, Natalie;Mumford, Virginia;Haywood, Philip. And the article was included in Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research in 2019.Formula: C16H21N3O2 This article mentions the following:

BACKGROUND: Migraine is a common, chronic, disabling headache disorder. Triptans, used as an acute treatment for migraine, are available via prescription in Australia. An Australian Therapeutic Goods Administration (TGA) committee rejected reclassifying sumatriptan and zolmitriptan from prescription medicine to pharmacist-only between 2005 and 2009, largely on the basis of concerns about patient risk. Nevertheless, pharmacist-only triptans may reduce migraine duration and free up healthcare resources. OBJECTIVES: To estimate the cost-effectiveness of reclassifying triptans from prescription-only to pharmacist-only in Australia. METHODS: The study design included decision-analytic modeling combining data from various sources. Behavior before and after reclassification was estimated using medical practitioner and patient surveys and also administrative data. Health outcomes included migraine frequency and duration as well as adverse events (AEs) discussed by the TGA committee. Efficacy and AEs were estimated using randomized controlled trials and observational studies. RESULTS: Reclassifying triptans will reduce migraine duration but increase AEs. This will result in 337 quality-adjusted life-years gained at an increased cost of A$5.9 million over 10 years for all Australian adults older than 15 years (19.6 million). The incremental cost-effectiveness ratio was estimated to be A$17 412/quality-adjusted life-year gained. CONCLUSIONS: The incremental cost-effectiveness ratio is likely to be considered cost-effective by Australian decision makers. Serotonin syndrome, a key concern of the TGA committee, had little impact on the results. Further research is needed regarding pharmacist-only triptan use by migraineurs currently using over-the-counter medicines and by nonmigraineurs, the efficacy of triptans, and the risk of cardiovascular and cerebrovascular AEs and chronic headaches with triptans. In the experiment, the researchers used many compounds, for example, (S)-4-((3-(2-(Dimethylamino)ethyl)-1H-indol-5-yl)methyl)oxazolidin-2-one (cas: 139264-17-8Formula: C16H21N3O2).

(S)-4-((3-(2-(Dimethylamino)ethyl)-1H-indol-5-yl)methyl)oxazolidin-2-one (cas: 139264-17-8) belongs to oxazolidine derivatives. Oxazolidine-based compounds have started to attract attention also in the medicinal and materials chemistry fields. Oxazolidines are commonly used as metal ligands in asymmetric catalysis, synthetic intermediates in organic synthesis, and also used as the protecting groups.Formula: C16H21N3O2

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Pseudoproline dipeptides in Fmoc-solid phase peptide synthesis was written by Doerner, Barbara;Steinauer, Rene;Barthelemy, Sophie;White, Peter D.. And the article was included in Peptide Science in 2005.Related Products of 252554-78-2 This article mentions the following:

This paper presents an overview on the application of Mutter’s pseudoproline dipeptides in the synthesis of difficult, phosphorylated and long peptides. Their use in enantiomerization-free fragment condensation is also described. In the experiment, the researchers used many compounds, for example, Fmoc-Ala-Ser[Psi(Me,Me)Pro]-OH (cas: 252554-78-2Related Products of 252554-78-2).

Fmoc-Ala-Ser[Psi(Me,Me)Pro]-OH (cas: 252554-78-2) belongs to oxazolidine derivatives. A common way to produce multisubstituted oxazolidines is by means of cycloaddition reactions. As well as other multifunctional heterocyclic compounds, oxazolidine rings play an essential role in organic and medicinal chemistry, behaving, in some cases as powerful antitumor agents.Related Products of 252554-78-2

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Multifunctional micelles dually responsive to hypoxia and singlet oxygen: Enhanced photodynamic therapy via interactively triggered Photosensitizer Delivery was written by Li, Juanjuan;Meng, Xuan;Deng, Jian;Lu, Di;Zhang, Xin;Chen, Yanrui;Zhu, Jundong;Fan, Aiping;Ding, Dan;Kong, Deling;Wang, Zheng;Zhao, Yanjun. And the article was included in ACS Applied Materials & Interfaces in 2018.Name: (S)-Benzyl 2-(2,5-dioxooxazolidin-4-yl)acetate This article mentions the following:

Nanoparticulate antitumor photodynamic therapy (PDT) has been suffering from the limited dose accumulation in tumor. Herein, we report dually hypoxia- and singlet oxygen-responsive polymeric micelles to efficiently utilize the photosensitizer deposited in the disease site and hence facilely improve PDT’s antitumor efficacy. Tailored methoxy poly(ethylene glycol)-azobenzene-poly(aspartic acid) copolymer conjugate with imidazole as the side chains was synthesized. The conjugate micelles (189 ± 19 nm) obtained by self-assembly could efficiently load a model photosensitizer, chlorin e6 (Ce6) with a loading of 4.1 ± 0.5% (weight/weight). The facilitated cellular uptake of micelles was achieved by the triggered azobenzene collapse that provoked poly(ethylene glycol) shedding; rapid Ce6 release was enabled by imidazole oxidation that induced micelle disassembly. In addition, the singlet oxygen-mediated cargo release not only addressed the limited diffusion range and short half-life of singlet oxygen but also decreased the oxygen level, which could in turn enhance internalization and increase the intracellular Ce6 concentration The hypoxia-induced dePEGylation and singlet oxygen-triggered Ce6 release was demonstrated both in aqueous buffer and in Lewis lung carcinoma (LLC) cells. The cellular uptake study demonstrated that the dually responsive micelles could deliver significantly more Ce6 to the cells, which resulted in a substantially improved cytotoxicity. This concurred well with the superior in vivo antitumor ability of micelles in a LLC tumor-bearing mouse model. This study presented an intriguing nanoplatform to realize interactively triggered photosensitizer delivery and improved antitumor PDT efficacy. In the experiment, the researchers used many compounds, for example, (S)-Benzyl 2-(2,5-dioxooxazolidin-4-yl)acetate (cas: 13590-42-6Name: (S)-Benzyl 2-(2,5-dioxooxazolidin-4-yl)acetate).

(S)-Benzyl 2-(2,5-dioxooxazolidin-4-yl)acetate (cas: 13590-42-6) belongs to oxazolidine derivatives. Oxazolidines are well known as key portions of bioactive molecules or precursors of chiral molecules, as well as established chiral auxiliaries. Oxazolidines are well known as key portions of bioactive molecules or precursors of chiral molecules, as well as established chiral auxiliaries.Name: (S)-Benzyl 2-(2,5-dioxooxazolidin-4-yl)acetate

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Metal-free stereoselective addition of propiolic acids to ynamides: a concise synthetic route to highly substituted enediyne/dienyne-(E)-N,O-acetals was written by Prasad, Rangu;Kanikarapu, Suresh;Dutta, Shubham;Vangara, Srinivas;Sahoo, Akhila K.. And the article was included in New Journal of Chemistry in 2022.Category: oxazolidine This article mentions the following:

A straightforward and sustainable approach for the 1,2-addition of propiolic acids to ynamide has led to bench-stable sp² (E)-enol-enamides of enediynes and dienynes. The reaction is chemo-, regio- and stereoselective and did not require metal catalysts and solvent. The ynamide motif is extremely amenable to functionalization in the presence of the tethered alkyne triple bond. The synthetic technique is operationally simple; no hydrolysis of ketenimine species occurs under acidic conditions. The transformation tolerates a wide range of common functional groups, constructing a library of highly functionalized 1,5,5’/6′-enediynes and 1,5,5′-dienynes of sp² (E)-N,O-acetal skeletons. In the experiment, the researchers used many compounds, for example, 3-(Phenylethynyl)oxazolidin-2-one (cas: 888329-88-2Category: oxazolidine).

3-(Phenylethynyl)oxazolidin-2-one (cas: 888329-88-2) belongs to oxazolidine derivatives. Oxazolidines are well known as key portions of bioactive molecules or precursors of chiral molecules, as well as established chiral auxiliaries. Oxazolidines are commonly used as metal ligands in asymmetric catalysis, synthetic intermediates in organic synthesis, and also used as the protecting groups.Category: oxazolidine

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Metformin and Other Pharmaceuticals Widespread in Wadeable Streams of the Southeastern United States was written by Bradley, Paul M.;Journey, Celeste A.;Button, Daniel T.;Carlisle, Daren M.;Clark, Jimmy M.;Mahler, Barbara J.;Nakagaki, Naomi;Qi, Sharon L.;Waite, Ian R.;Van Metre, Peter C.. And the article was included in Environmental Science & Technology Letters in 2016.Formula: C12H15NO3 This article mentions the following:

Pharmaceutical contaminants are growing aquatic-health concerns and largely attributed to wastewater treatment facility (WWTF) discharges. Five biweekly water samples from 59 small Piedmont (USA) streams were analyzed for 108 pharmaceuticals and degradates using high-performance liquid chromatog. and tandem mass spectrometry. The antidiabetic metformin was detected in 89% of samples and at 97% of sites. At least one pharmaceutical was detected at every site (median of 6, maximum of 45), and several were detected at ≥10% of sites at concentrations reported to affect multiple aquatic end points. Maximal cumulative (all detected compounds) concentrations per site were 17-16000 ng/L. Watershed urbanization, water table depth, soil thickness, and WWTF metrics correlated significantly with instream pharmaceutical contamination. Comparable pharmaceutical concentrations and detections at sites with and without permitted wastewater discharges demonstrate the importance of non-WWTF sources and the need for broad-scale mitigation. The results highlight a fundamental biochem. link between global human-health crises like diabetes and aquatic ecosystem health. In the experiment, the researchers used many compounds, for example, 5-((3,5-Dimethylphenoxy)methyl)oxazolidin-2-one (cas: 1665-48-1Formula: C12H15NO3).

5-((3,5-Dimethylphenoxy)methyl)oxazolidin-2-one (cas: 1665-48-1) belongs to oxazolidine derivatives.Oxazolidines are readily available also from propargyl amines. Some reports highlighted again the effectiveness of oxazolidine-based compounds in driving the stereo- or diastereotopic outcome of chemical reactions.Formula: C12H15NO3

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Visible light photocatalytic asymmetric synthesis of pyrrolo[1,2-a]indoles via intermolecular [3+2] cycloaddition was written by Casado-Sanchez, Antonio;Domingo-Legarda, Pablo;Cabrera, Silvia;Aleman, Jose. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2019.Safety of (S)-4-Phenyloxazolidin-2-one This article mentions the following:

The intermol. diastereoselective and enantioselective synthesis of pyrrolo[1,2-a]indoles is developed through a [3 + 2] cycloaddition between silyl-indole derivatives and α,β-unsaturated N-acyl oxazolidinones by merging photocatalysis and Lewis acid catalysis. In the experiment, the researchers used many compounds, for example, (S)-4-Phenyloxazolidin-2-one (cas: 99395-88-7Safety of (S)-4-Phenyloxazolidin-2-one).

(S)-4-Phenyloxazolidin-2-one (cas: 99395-88-7) belongs to oxazolidine derivatives. Oxazolidine-based compounds are well-known chiral auxiliaries and strategic molecular moieties in chemistry since they can effectively mask or mimic amino acid units or amino alcohols. Chiral oxazolidines are widely used as chiral auxiliaries, chiral ligands, protecting and/or directing groups in a variety of asymmetric transformations, thanks also to their easy cleavage or their further elaboration possibilities.Safety of (S)-4-Phenyloxazolidin-2-one

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Enantioseparation properties of the biselector chiral stationary phase derived from amylose tris(phenylcarbamate) and amylose tris(benzoate) was written by Chen, Jun;Duan, Rong;Chen, Wei;Zhang, Juan;Luo, Xiao-Gang;Li, Jian;Bai, Zheng-Wu. And the article was included in Current Analytical Chemistry in 2013.SDS of cas: 99395-88-7 This article mentions the following:

To study the enantioseparation property of the biselector chiral stationary phase derived from polysaccharide, a new biselector chiral stationary phase was prepared by coating a blend of two amylose derivatives on an aminated silica gel. The blend consisted of amylose tris(phenylcarbamate) and amylose tris(benzoate) at a glucose unit ratio of 1:1 (mol/mol). For the sake of enantioseparation comparison, the corresponding single selector chiral stationary phases were also prepared with the two individual amylose derivatives The enantioseparation ability of these chiral stationary phases was evaluated by using structurally various chiral analytes. The biselector chiral stationary phase showed an overall improved enantioseparation ability in comparison with the two single selector chiral stationary phases. The effect of alcs. in mobile phase on the enantioseparation of the biselector chiral stationary phase is also discussed. In the experiment, the researchers used many compounds, for example, (S)-4-Phenyloxazolidin-2-one (cas: 99395-88-7SDS of cas: 99395-88-7).

(S)-4-Phenyloxazolidin-2-one (cas: 99395-88-7) belongs to oxazolidine derivatives. Oxazolidine-based compounds have started to attract attention also in the medicinal and materials chemistry fields. As well as other multifunctional heterocyclic compounds, oxazolidine rings play an essential role in organic and medicinal chemistry, behaving, in some cases as powerful antitumor agents.SDS of cas: 99395-88-7

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem