Category: 90719-32-7

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.90719-32-7,(S)-4-Benzyloxazolidin-2-one,as a common compound, the synthetic route is as follows.

A solution of (S) -4-benzyl-oxazolidine-2-one (6.13g, 0. 035 [pi] o1) was added to the reaction flask under nitrogen atmosphere ,Dry tetrahydrofuran 90ml,Stirring. Potassium tert-butoxide (5. 03 g, 0.049 mol) was added at 0 C to afford Stirring was continued for 2 hours at low temperature and isovaleryl chloride (4.8 g, 0.039 mol) was added dropwise at 0 C,Of tetrahydrofuran solution 10ml, the temperature at 0 C or so, after the completion of the drop,TCL detection reaction is complete. 20 ml of saturated ammonium chloride solution was added dropwise, and the solvent was distilled off under reduced pressure.The residue was extracted with dichloromethane, 60 ml each, extracted three times and the organic phases were combined.Organic phase by adding lmol / L NaOH 60ml extraction, organic phase and then saturated with saline 60ml wash to neutral,Dried over anhydrous sodium sulfate, the solvent was evaporated under reduced pressure, and evaporated to an oil. To this was added 60 ml of hexane,A large number of white solid precipitation, filtration, vacuum drying, (S)-4-benzyl-3-(3-methylbutanoyl)oxazolidine-2-one as a white needles (8.lg, 90% yield), m.p. 49-50 C. Optical rotation measured data:[[alpha]]15D+54.8(C1.0CHCl3), The data reported in the literature: [[alpha]]25D+55.8(C1.0CHCl3)

90719-32-7 (S)-4-Benzyloxazolidin-2-one 736225, aoxazolidine compound, is more and more widely used in various.

Reference£º
Patent; Shanghai Institute of Pharmaceutical Industry; Xu, Wen Yan; Wang, guan; Guo, yekun; Zhong, jingfen; Shi, huilin; (6 pag.)CN102452994; (2016); B;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

90719-32-7, (S)-4-Benzyloxazolidin-2-one is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

4-Dimethylaminopyridine (2.55 g, 21.3 mmol) and triethylamine (46.9 ml, 340.8 mmol) in dichloromethane (100 ml) are added to a solution of (S)-(-)-4-benzyl-2-oxazolidinone (37.7 g, 213 mmol) in dichloromethane (300 ml). Next, isovaleroyl chloride (33.75 ml, 207 mmol) in dichloromethane (50 ml) is added to the previously prepared mixture and cooled to 0 C. keeping the internal temperature below 10 C. The reaction mixture is stirred for 30 minutes at 10 C., then the formed salts are filtered. Water (100 ml) is added and the phases are separated. The organic phase is washed with water (100 ml) and brine (100 ml), dried over sodium sulphate and evaporated to dryness obtaining 53 g of a yellow oil, which solidifies over time (yield 95%). 1H NMR (300 MHz, CDCl3, 298K) delta 7.35-7.15 (m, 5H), 4.71-4.61 (m, 1H), 4.21-4.10 (m, 2H), 3.35-3.25 (dd, J=13.2, J=3.4 Hz.1H), 2.85-2.72 (dd, J=14.97 Hz, 6.8 Hz, 1H), 2.80-2.67 (m, 2H), 2.29-2.12 (sept, J=13.2 Hz.1H), 1.03-0.98 (d, J=6.8 Hz.3H), 0.98-0.95 (d, J=6.8 Hz, 3H). 13C NMR (75 MHz, CDCl3, 298K) delta 175.6, 171.2, 154.4, 137.1, 130.5, 130.2, 126.0, 82.1, 66.1, 45.6, 42.6, 41.4, 34.0, 28.7, 27.3, 19.7.

The synthetic route of 90719-32-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Chemo Iberica, S.A.; Taddei, Maurizio; Russo, Adele; Cini, Elena; Riva, Renata; Rasparini, Marcello; Carcone, Luca; Banfi, Luca; Vitale, Romina; Roseblade, Stephen; Zanotti-Gerosa, Antonio Carlo; US2013/71899; (2013); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem