Category: 7517-99-9

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Resolution of 5-hydroxymethyl-2-oxazolidinone by preferential crystallization and investigations on the nature of the racemates of some 2-oxazolidinone derivatives

After ascertaining its conglomerate nature by DSC and solid-state IR analyses, 5-hydroxymethyl-2-oxazolidinone 1, whose enantiomers are very important synthons, was efficiently resolved without chiral auxiliaries by preferential crystallization from a supersaturated isopropanolic solution of the racemate, slightly enriched in one enantiomer (3.7% ee). Favourable conditions to the entrainment were defined utilizing the previously constructed ternary phase diagram {(R)-1, (S)-1, 2-propanol}. Furthermore, the investigations were extended to other chiral 2-oxazolidinones with a functionalized methyl at the 5- or 4-position finding that 5-tosyloxymethyl-2-oxazolidinone is a racemic compound, whereas just the corresponding mesylate is a conglomerate as the parent alcohol 1. Interestingly, 4-hydroxymethyl-2-oxazolidinone 4 proved to be a racemic compound in contrast with its positional isomer 1 demonstrating how a relatively fine variation in the molecular structure can unpredictably influence the crystalline nature of the racemate. The X-ray structure determination carried out on (S)-(+)-1, (±)-4 and (R)-(+)-4 enlightened the importance of the hydrogen bond in determining different supramolecular assembling in the two homochiral compounds with respect to the racemic one and allowed a correlation with the stability of the crystal to be made.

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Reference：
Oxazolidine – Wikipedia,
Oxazolidine | C3H1312NO – PubChem

 

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Process for the preparation of 5-hydroxymethyl 2-oxazolidinone and novel intermediate

A process for preparing 5-hydroxymethyl-2-oxazolidinone (1), preferably optically active, in one step from 3,4-boronic acid ester protected 3,4-dihydroxybutyramides (2) is described. The oxazolidinone is important in the pharmaceutical industry especially in the areas of antimicrobials and behavioral disorders.

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Reference：
Oxazolidine – Wikipedia,
Oxazolidine | C3H1298NO – PubChem

 

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Heterometallic metal-organic framework-templated synthesis of porous Co3O4/ZnO nanocage catalysts for the carbonylation of glycerol

The efficient synthesis of glycerol carbonate (GLC) has recently received great attention due to its significance in reducing excess glycerol in biodiesel production as well as its promising applications in several industrial fields. However, the achievement of high conversion and high selectivity of GLC from glycerol in heterogeneous catalytic processes remains a challenge due to the absence of high-performance solid catalysts. Herein, highly porous nanocage catalysts composed of well-mixed Co3O4 and ZnO nanocrystals were successfully fabricated via a facile heterometallic metal-organic framework (MOF)-templated synthetic route. Benefiting from a high porosity and the synergistic effect between Co3O4 and ZnO, the as-prepared composite catalysts exhibited a significantly enhanced production efficiency of GLC in the carbonylation reaction of glycerol with urea compared to the single-component counterparts. The yield of GLC over the Co50Zn50-350 catalyst reached 85.2%, with 93.3% conversion and near 91% GLC selectivity, and this catalytic performance was superior to that over most heterogeneous catalysts. More importantly, the proposed templated synthetic strategy of heterometallic MOFs facilitates the regulation of catalyst composition and surface structure and can therefore be potentially extended in the tailoring of other metal oxide composite catalysts.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Computed Properties of C4H7NO3, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 7517-99-9, in my other articles.

Reference：
Oxazolidine – Wikipedia,
Oxazolidine | C3H1308NO – PubChem

 

Chemistry is traditionally divided into organic and inorganic chemistry. Quality Control of 5-(Hydroxymethyl)oxazolidin-2-one, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 7517-99-9

Comprehensive spectral identification of key intermediates to the final product of the chiral pool synthesis of radezolid

Radezolid (RAD, 12), biaryl oxazolidinone, was synthesised with small modifications according to the methods described in the literature. The pharmacological activity is observed only for (S)-enantiomer, therefore its synthesis is oriented towards obtaining a single isomer of required purity and desired optical configuration. The intermediate products of RAD synthesis were characterised using 1H- and 13C-NMR, as well as the 2D correlation HSQC and HMBC (2, 5, 9, 10), furthermore studied using infrared radiation (FT-IR), Raman scattering (3, 5, 9), and electronic circular dichroism (ECD) (5, 12) spectroscopy. Each technique provides a unique and specific set of information. Hence, the full spectral characteristics of key intermediates obtained from the chiral pool synthesis to the finished product of RAD were summarised and compared. For a more accurate analysis, and due to the lack of reliable and reproducible reference standards for intermediate products, their vibrational analysis was supported by quantum chemical calculations based on the density functional theory (DFT) utilising the B3LYP hybrid functional and the 6-311G(d,p) basis set. Good agreement was observed between the empirical and theoretical spectra.[Figure not available: see fulltext.]

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Oxazolidine – Wikipedia,
Oxazolidine | C3H1311NO – PubChem

 

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Synthesis of azachrysenes and multi-nitrogenated derivatives

Azachrysenes are aromatic tetracyclic structures where one carbon atom is replaced by nitrogen in any symmetrically distinct position of the fused aromatic ring. They can be considered analogs of azasteroids, with recognized potential as drug candidates. The present review surveys the work carried out over the last three decades on the synthesis of mono-, di-, tri- and penta-azachryzene derivatives. Although a diversity of synthetic approaches were described in the literature, there are no recent review articles on this subject.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H1310NO – PubChem

 

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Single heterocyclic compounds as monoamine oxidase inhibitors: From past to present

Inhibitors of monoamine oxidase (MAO) have shown therapeutic values in a variety of neu-rodegenerative diseases such as depression, Parkinson?s disease and Alzheimer?s disease. Heterocyclic compounds exhibit a broad spectrum of biological activities and vital leading compounds for the development of chemical drugs. Herein, we focus on the synthesis and screening of novel single hetero-cyclic derivatives with MAO inhibitory activities during the past decade. This review covers recent pharmacological advancements of single heterocyclic moiety along with structure-activity relationship to provide better correlation among different structures and their receptor interactions.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H1315NO – PubChem

 

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Bicyclo[3,1,0]hexane containing oxazolidinone antibioytics and derivatives thereof

Oxazolidinones having a bicyclic[3.1.0] hexane containing moiety, which are effective against aerobic and anerobic pathogens such as multi-resistant staphylococci, streptococci and enterococci, Bacteroides spp., Clostridia spp. species, as well as acid-fast organisms such as Mycobacterium tuberculosis and other mycobacterial species. The compounds are represented by structural formula I: 1its enantiomer, diastereomer, or pharmaceutically acceptable salt or ester thereof, and wherein the variables R1, R2, R3, R4, R4a, A, Ar, HAr, n, r, and s are as defined herein.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H1300NO – PubChem

 

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Copper-catalyzed N-arylation of 2-oxazolidinones. An expeditious route to toloxatone

3-Aryl-2-oxazolidinones are obtained in excellent yields through the copper-catalyzed N-arylation of 2-oxazolidinones with a variety of aryl iodides. With aryl halides containing both iodo and bromo substituents, a high C-I/C-Br selectivity can be achieved. The procedure has been successfully applied to the preparation of a key intermediate in the synthesis of linezolid and to develop an expeditious route to toloxatone.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H1303NO – PubChem

 

Application of 7517-99-9, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 7517-99-9, molcular formula is C4H7NO3, introducing its new discovery.

Antibiotics in the clinical pipeline at the end of 2015

There is growing global recognition that the continued emergence of multidrug-resistant bacteria poses a serious threat to human health. Action plans released by the World Health Organization and governments of the UK and USA in particular recognize that discovering new antibiotics, particularly those with new modes of action, is one essential element required to avert future catastrophic pandemics. This review lists the 30 antibiotics and two beta-lactamase/beta-lactam combinations first launched since 2000, and analyzes in depth seven new antibiotics and two new beta-lactam/beta-lactamase inhibitor combinations launched since 2013. The development status, mode of action, spectra of activity and genesis (natural product, natural product-derived, synthetic or protein/mammalian peptide) of the 37 compounds and six beta-lactamase/beta-lactam combinations being evaluated in clinical trials between 2013 and 2015 are discussed. Compounds discontinued from clinical development since 2013 and new antibacterial pharmacophores are also reviewed.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 7517-99-9 is helpful to your research. Application of 7517-99-9

Reference£º
Oxazolidine – Wikipedia,
Oxazolidine | C3H1302NO – PubChem

 

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Highly efficient CuI-catalyzed coupling of aryl bromides with oxazolidinones using Buchwald’s protocol: a short route to linezolid and toloxatone.

[reaction: see text] Coupling of a variety of substituted aryl bromides with oxazolidinones has been achieved using the Buchwald protocol for the amidation of aryl halides. This procedure is exemplified by the synthesis of two medicinally important molecules, linezolid and toloxatone.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H1309NO – PubChem