Category: 70-23-5

Related Products of 70-23-5. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: Ethyl 3-bromo-2-oxopropanoate, is researched, Molecular C5H7BrO3, CAS is 70-23-5, about Ionic liquid promoted green synthesis of new pyridazino benzazepine derivatives: Evaluation of antioxidant activity. Author is Dehbandi, Behnam; Hossaini, Zinatossadat; Mirjafari, Zohreh; Zardoost, Mohammad Reza.

In this research, preparation of pyridazino benzazepine derivatives I (R = H, methoxycarbonyl, ethoxycarbonyl; R1 = ethoxycarbonyl, 4-chlorophenyl, 4-methylphenyl, etc.; X = H, Me, Cl, NO2) in high yields were investigated via the domino and one-pot reaction of isatoic anhydrides II, N-methylimidazole, alkyl bromides R1C(O)CH2Br, activated acetylenic compounds RCCC(O)OR2 (R2 = Me, Et), and hydrazine in ionic liquid as green media at 80°C. Also, antioxidation property of some prepared pyridazino benzazepines I due to having pyridazine and benzazepine core is investigated by employing of trapping diphenyl-picrylhydrazine radical and ability of ferric reduction experiment This procedure has a few benefits relative to reported method such as good rate of reaction, product with high efficiency, and simple separation of product from mixture of reaction.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, Non-U.S. Gov’t, Journal of Antimicrobial Chemotherapy called Repurposing ethyl bromopyruvate as a broad-spectrum antibacterial, Author is Kumar, Ajay; Boradia, Vishant Mahendra; Thakare, Ritesh; Singh, Alok Kumar; Gani, Zahid; Das, Swetarka; Patidar, Anil; Dasgupta, Arunava; Chopra, Sidharth; Raje, Manoj; Raje, Chaaya Iyengar, which mentions a compound: 70-23-5, SMILESS is O=C(OCC)C(CBr)=O, Molecular C5H7BrO3, Synthetic Route of C5H7BrO3.

Background: The emergence of drug-resistant bacteria is a major hurdle for effective treatment of infections caused by Mycobacterium tuberculosis and ESKAPE pathogens. In comparison with conventional drug discovery, drug repurposing offers an effective yet rapid approach to identifying novel antibiotics. Methods: Et bromopyruvate was evaluated for its ability to inhibit M. tuberculosis and ESKAPE pathogens using growth inhibition assays. The selectivity index of Et bromopyruvate was determined, followed by time-kill kinetics against M. tuberculosis and Staphylococcus aureus. We first tested its ability to synergize with approved drugs and then tested its ability to decimate bacterial biofilm. Intracellular killing of M. tuberculosis was determined and in vivo potential was determined in a neutropenic murine model of S. aureus infection. Results: We identified Et bromopyruvate as an equipotent broad-spectrum antibacterial agent targeting drug-susceptible and -resistant M. tuberculosis and ESKAPE pathogens. Et bromopyruvate exhibited concentration-dependent bactericidal activity. In M. tuberculosis, Et bromopyruvate inhibited GAPDH with a concomitant reduction in ATP levels and transferrin-mediated iron uptake. Apart from GAPDH, this compound inhibited pyruvate kinase, isocitrate lyase and malate synthase to varying extents. Et bromopyruvate did not neg. interact with any drug and significantly reduced biofilm at a 64-fold lower concentration than vancomycin. When tested in an S. aureus neutropenic thigh infection model, Et bromopyruvate exhibited efficacy equal to that of vancomycin in reducing bacterial counts in thigh, and at 1/25th of the dosage. Conclusions: Et bromopyruvate exhibits all the characteristics required to be positioned as a potential broad-spectrum antibacterial agent.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: Ethyl 3-bromo-2-oxopropanoate, is researched, Molecular C5H7BrO3, CAS is 70-23-5, about Small-molecule inhibitor of AF9/ENL-DOT1L/AF4/AFF4 interactions suppresses malignant gene expression and tumor growth, the main research direction is imidazole preparation malignant gene expression suppression antitumor; Cancer therapeutics; MLL-rearranged leukemia; Protein-protein interaction; Small-molecule inhibitor; Super elongation complexes.Reference of Ethyl 3-bromo-2-oxopropanoate.

Chromosome translocations involving mixed lineage leukemia (MLL) gene cause acute leukemia with a poor prognosis. MLL is frequently fused with transcription cofactors AF4 (~35%), AF9 (25%) or its paralog ENL (10%). The AHD domain of AF9/ENL binds to AF4, its paralog AFF4, or histone-H3 lysine-79 (H3K79) methyltransferase DOT1L. Formation of AF9/ENL/AF4/AFF4-containing super elongation complexes (SEC) and the catalytic activity of DOT1L are essential for MLL-rearranged leukemia. Protein-protein interactions (PPI) between AF9/ENL and DOT1L/AF4/AFF4 are therefore a potential drug target. Compound I was identified to be a novel small-mol. inhibitor of the AF9/ENL-DOT1L/ AF4/AFF4 interaction with IC50s of 0.9-3.5μM. Pharmacol. inhibition of the PPIs significantly reduced SEC and DOT1L-mediated H3K79 methylation in the leukemia cells. Gene profiling shows compound I significantly suppressed the gene signatures related to onco-MLL, DOT1L, HoxA9 and Myc. It selectively inhibited proliferation of onco-MLL- or Myc-driven cancer cells and induced cell differentiation and apoptosis. Compound I exhibited strong antitumor activity in a mouse model of MLL-rearranged leukemia. The AF9/ENL-DOT1L/AF4/AFF4 interactions are validated to be an anticancer target and compound I is a useful in vivo probe for biol. studies as well as a pharmacol. lead for further drug development.

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Ejaz, Saima; Nadeem, Humaira; Paracha, Rehan Zafar; Sarwar, Sadia; Ejaz, Sadaf published the article 《Designing, synthesis and characterization of 2-aminothiazole-4-carboxylate Schiff bases; antimicrobial evaluation against multidrug resistant strains and molecular docking》. Keywords: Escherichia Staphylococcus Candida aminothiazole antimicrobial mol docking; 2-Aminothiazole; Antifungal activity; Antimicrobial evaluation; Minimum inhibitory concentration; Molecular docking; Schiff bases.They researched the compound: Ethyl 3-bromo-2-oxopropanoate( cas:70-23-5 ).Reference of Ethyl 3-bromo-2-oxopropanoate. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:70-23-5) here.

Background: 2-Aminothiazoles are significant class of organic medicinal compounds utilized as starting material for the synthesis of diverse range of heterocyclic analogs with promising therapeutic roles as antibacterial, antifungal, anti-HIV, antioxidant, antitumor, anthelmintic, anti-inflammatory & analgesic agents. Exptl.: Eight compounds 1a, 2a-2g were synthesized and characterized by FTIR and NMR (1H and 13C). Evaluation of antibacterial potential against multi-drug resistant clin. isolates was performed and min. inhibitory concentration (MIC) values were determined Antifungal activity was also performed. Protein-ligand interactions of compounds with target enzyme were evaluated through docking studies. Results: Resistance profiling of bacterial clin. isolates (MDRs) depicted that some standard drugs used were not active against these MDRs while our synthesized compounds showed good MIC values. Among all the synthesized compounds, 2a and 2b showed significant antibacterial potential towards gram-pos. Staphylococcus epidermidis and gram-neg. Pseudomonas aeruginosa at MIC 250 μg/mL and 375 μg/mL resp. Likewise, compound 2d and 2g exhibited inhibitory potential against gram-pos. Staphylococcus aureus and gram-neg. Escherichia coli at MIC values of 250 and 375 μg/mL resp. Compound 2b showed maximum antifungal potential against Candida glabrata (ATCC 62934) with a zone of inhibition 21.0 mm as compared to the reference drug nystatin which showed lesser antifungal potential with a zone of inhibition of 19.1 mm. Candida albicans (ATCC 60387) showed maximum sensitivity to compound 2a with a zone of inhibition 20.0 mm. Its antifungal activity is more in comparison to reference drug nystatin with exhibited the zone of inhibition of 19.3 mm. Designed compounds were docked with the target enzyme UDP-N-acetylmuramate/L-alanine ligase. The compound 2b showed highest binding affinity (- 7.6 kcal/mol). Conclusions: The synthesized compounds showed moderate to significant antibacterial and antifungal potential. It is clear from the binding affinities that compounds having hydroxyl group substituted on benzene ring possess strong binding affinity as compared to other analogs. These designed compounds could be considered to act as antagonists against target UDP-N-acetylmuramate/L-alanine ligase.

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Name: Ethyl 3-bromo-2-oxopropanoate. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Ethyl 3-bromo-2-oxopropanoate, is researched, Molecular C5H7BrO3, CAS is 70-23-5, about Bio-Fe3O4-MNPs catalyzed green synthesis of pyrrolo[2,1-a]isoquinoline derivatives using isoquinolium bromide salts: study of antioxidant activity. Author is Abbasi, Maryam; Zamani Hargalani, Fariba; Afrashteh, Siavash; Rostamian, Rezvaneh.

A novel, one-pot, efficient procedure with high yield for the synthesis of pyrrolo[2,1-a]isoquinoline derivatives I [R = ethoxycarbonyl, 4-methylphenyl, 4-bromophenyl, etc.; R1 = ethoxycarbonyl, 4-methylphenyl, 4-methoxyphenyl] using multi-component reaction of isoquinoline, alkyl bromides and triphenylphosphine in the presence of Fe3O4-MNPs as catalyst under solvent-free conditions at room temperature was investigated. This study highlighted an easy, simple, rapid and clean method for the preparation of pyrrolo[2,1-a]isoquinoline derivatives The Fe3O4-MNPs in these reactions were produced employing a green procedure by reduction of ferric chloride solution with pomegranate peel water extract Addnl., antioxidant activity was studied for the some newly synthesized compounds such as I [R1 = ethoxycarbonyl; R = ethoxycarbonyl, 4-methoxyphenyl, 4-methylphenyl, 4-bromophenyl]using the DPPH radical trapping and reducing potential of ferric ion experiments and comparing the results with the results of synthetic antioxidants (2-tert-butylhydroquinone, TBHQ; butylated hydroxytoluene, BHT). As a result, compounds [R1 = ethoxycarbonyl; R = ethoxycarbonyl, 4-methoxyphenyl, 4-methylphenyl, 4-bromophenyl] show trace DPPH radical trapping and excellent reducing power of ferric ion.

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Oxazolidine – Wikipedia,
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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Journal of Heterocyclic Chemistry called Green Synthesis of Imidazole Derivatives using Fe3O4-MNPs as Reusable Catalyst, Author is Shafaei, Faezeh; Sharafian, Shirin, which mentions a compound: 70-23-5, SMILESS is O=C(OCC)C(CBr)=O, Molecular C5H7BrO3, Reference of Ethyl 3-bromo-2-oxopropanoate.

In this research, a one-pot, efficient, and high yielding procedure for the synthesis of imidazole derivatives I (R = H, Me; R1 = tert-Bu, Ph, 4-BrC6H4, etc.; R2 = COOEt, 4-MeOC6H4, 4-O2NC6H4) is investigated. The procedure was carried out via multicomponent reaction of isothiocyanate, alkyl bromides, N-methylimidazole, and triphenylphosphine in the presence of magnetic iron oxide nanoparticles (Fe3O4-MNPs) as reusable catalyst under solvent-free conditions at 50°. Also, Fe3O4-MNPs were produced using green synthetic method by reduction of ferric chloride solution with Clover Leaf water extract The nanoparticles generated using this procedure can potentially be important in different purposes such as organic synthesis. These procedures have some advantages such as easy separation of products, green conditions, and reusability and easy separation of catalyst.

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COA of Formula: C5H7BrO3. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Ethyl 3-bromo-2-oxopropanoate, is researched, Molecular C5H7BrO3, CAS is 70-23-5, about Green synthesis of pyrrolo isoquinolines using in situ synthesis of 4-hydroxycoumarines: Study of antioxidant activity. Author is Mousavi, Seyyedeh Fatemeh; Hossaini, Zinatossadat; Rostami-Charati, Faramarz; Nami, Navabeh.

In this research, synthesis of pyrrolo isoquinoline derivatives I (R = COOEt, Ph, 4-MeC6H4, 4-MeOC6H4, 4-O2NC6H4; R1 = Me, OMe, NO2; R2 = H, Me) in excellent yields was performed using the multicomponent reaction of isoquinoline, alkyl bromides, 2-hydroxyacetophenone, or its derivatives, di-Me carbonate as a green reagent and KF/clinoptinolite nanoparticles as a catalyst in the aqueous media at 80°. The Punica granatum peel water extract was used as the green media for the synthesis of PG-KF/clinoptilolite nanoparticles in high yield. The PG-KF/clinoptilolite nanoparticles show a significant basic catalytic role in these reactions in preparing the product in high yield and used for several times. In addition, for studying the antioxidant ability of some of the synthesized compounds, diphenyl-picrylhydrazine (DPPH) radical trapping and power of ferric reduction tests are employed. The short time of the reaction, high yields of the product, easy separation of the catalyst and products are some of the advantages of this procedure.

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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 70-23-5, is researched, SMILESS is O=C(OCC)C(CBr)=O, Molecular C5H7BrO3Journal, Asian Journal of Chemistry called Novel synthetic strategy of cyclic dithiocarbamates catalyzed by triton-B, Author is Kishore, R.; Kamboj, M.; Shukla, M.; Srivastava, N., the main research direction is cyclic dithiocarbamate preparation green chem antibacterial antifungal; amine carbon disulfide ethyl bromopyruvate multicomponent triton B catalyst.Electric Literature of C5H7BrO3.

A simple, rapid and green methodol. to synthesize cyclic dithiocarbamates I [R = (4-methoxyphenyl)methyl, pentyl, cyclopentyl, etc.] was developed by the reaction of 1° amines RNH2, CS2 and Et 3-bromo-2-oxopropanoate (Et bromopyruvate) facilitated by Triton-B as phase transfer catalyst. In vitro antimicrobial activities of these compounds I are reported against the pathogenic bacteria and fungi.

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Oxazolidine – Wikipedia,
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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Ethyl 3-bromo-2-oxopropanoate, is researched, Molecular C5H7BrO3, CAS is 70-23-5, about Efficient synthesis of new oxadiazole-thiazole hybrids using (diacetoxyiodo)benzene.COA of Formula: C5H7BrO3.

An efficient synthesis of some new 2-aryl-5-(2′-(4-nitrophenylamino)thiazol-4′-yl)-1,3,4-oxadiazoles I (R = H, Cl, Br, F, Me), has been accomplished through oxidative cyclization of 2-(4-nitrophenylamino)-N’-(substituted benzylidene)thiazole-4-carbohydrazides II using an ecofriendly oxidant, (diacetoxyiodo)benzene at ambient temperature The reaction can tolerate a wide range of aldehydes 4-RC6H4CHO to afford the corresponding unsym. 2,5-disubstituted 1,3,4-oxadiazoles I. The mild reaction conditions, relatively benign nonmetallic oxidant and short reaction time are noteworthy advantages of this methodol.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Synthesis and biological evaluation of 2-chloro-3-[(thiazol-2-yl)amino]-1,4-naphthoquinones, published in 2019-07-01, which mentions a compound: 70-23-5, Name is Ethyl 3-bromo-2-oxopropanoate, Molecular C5H7BrO3, Synthetic Route of C5H7BrO3.

A series of novel, substituted 2-chloro-3-[(thiazol-2-yl)amino]-1,4-naphthoquinones have been prepared and shown to exhibit promising concentration-dependent activity against human SH-SY5Y cells, Plasmodium falciparum, Mycobacterium tuberculosis and P. aeruginosa. Substituent effects on observed bioactivity have been explored; the para-fluorophenyl derivative I exhibited activity across the range of the bioassays employed, indicating the potential of the 2-chloro-3-[(4-arylthiazol-2-yl)amino]-1,4-naphthoquinone scaffold in the development of novel, broad spectrum therapeutics.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem