Category: 70-23-5

Related Products of 70-23-5. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: Ethyl 3-bromo-2-oxopropanoate, is researched, Molecular C5H7BrO3, CAS is 70-23-5, about Green synthesis and evaluation of antioxidant and antimicrobial activity of new dihydropyrroloazepines: Using bio-Ag/CdO/ZnO@MWCNTs nanocomposites as a reusable organometallic catalyst. Author is Noushin, Annataj; Varasteh-Moradi, Ali; Sayyed-Alangi, S. Zahra; Hossaini, Zinatossadat.

In this study a new, economical and green method was reported for the synthesis of Ag/CdO/ZnO@MWCNTs nanocomposites (Ag/CdO/ZnO@MWCNTs NCs) as a new heterogeneous catalyst. For confirming the structure of synthesized nanocatalyst, XRD, FESEM, EDX and TEM anal. were utilized. The Ag/CdO/ZnO@MWCNTs NCs as a high performance catalyst was employed for the preparation of a new family of substituted dihydropyrroloazepines I [R = CO2Et, Ph, 4-MeC6H4, 4-MeOC6H4, 4-O2NC6H4; R1 = CO2Et, 4-BrC6H4, 4-MeOC6H4, 4-O2NC6H4] using the one-pot condensation reactions of isatin, ammonium acetate, α-haloketones and activated acetylenic compounds in water at room temperature Another work in this research was investigation of antioxidant property of some synthesized compounds I by diphenyl-picrylhydrazine (DPPH) radical trapping experiment Addnl., for confirming the antibacterial activity of some dihydropyrroloazepines, disk diffusion test was used on two kinds of bacteria.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Ethyl 3-bromo-2-oxopropanoate, is researched, Molecular C5H7BrO3, CAS is 70-23-5, about New BI and TRI-Thiazole copper (II) complexes in the search of new cytotoxic drugs against breast cancer cells.Recommanded Product: Ethyl 3-bromo-2-oxopropanoate.

New thiazolyl derivatives (BT and TT) and their copper (II) complexes [Cu2Cl2(BT)2] (Cu-BT) and [Cu4ClO2(TT)2]PF6·3.5H2O (Cu-TT) were synthesized and characterized by elemental anal., 1H NMR and 13C NMR, HRMS, X-ray diffraction, IR and UV-Vis spectroscopies. The crystal structure of Cu-BT shows the formation of a dinuclear complex where each copper(II) center is bonded to two thiazol N atoms, from different BT ligands, one deprotonated amide N atom, an O atom from the ester terminal groups and a chlorine atom. The structure found for Cu-TT is a pos. charged tetranuclear moiety containing two deprotonated TT ligands, a chlorine anion, two hydroxide anions acting as bridges between the copper centers and a water mol. The cytotoxic activity of both copper complexes was evaluated on metastatic breast cancer cell lines, characterized for its rapidly dividing behavior. Both, Cu-BT and Cu-TT, show higher cytotoxic activity against these tumor cells than free BT and TT and also than cisplatin. In addition, we found that both complexes interact with DNA. Consistently, they also show cytotoxicity against a rapidly dividing non-tumor cell line, although with higher IC50, being such interaction and selectivity an indicator of the possible coexistence of more than one mechanism of action.

In addition to the literature in the link below, there is a lot of literature about this compound(Ethyl 3-bromo-2-oxopropanoate)Recommanded Product: Ethyl 3-bromo-2-oxopropanoate, illustrating the importance and wide applicability of this compound(70-23-5).

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Crystal engineering with pyrazolyl-thiazole derivatives: structure-directing role of π-stacking and σ-hole interactions, published in 2021, which mentions a compound: 70-23-5, Name is Ethyl 3-bromo-2-oxopropanoate, Molecular C5H7BrO3, Product Details of 70-23-5.

The synthesis and X-ray characterization of 1-(2-(3-(4-bromophenyl)-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl)-4-methylthiazol-5-yl)ethanone (7), Et 2-(5-(4-bromophenyl)-3-(4-chlorophenyl)-4,5-dihydropyrazol-1-yl)thiazole-4-carboxylate (8) and 2-(5-(4-chlorophenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)-N’-(2-hydroxy-3-methoxybenzylidene)thiazole-4-carbohydrazide (10) are described in this manuscript. The structure-directing role of a variety of noncovalent interactions has been analyzed energetically using DFT calculations and Hirshfeld surface anal. Moreover, the existence and importance of halogen and chalcogen bonding interactions have been analyzed by using the quantum theory of atoms in mols. and the noncovalent interaction index (NCIplot).

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: Ethyl 3-bromo-2-oxopropanoate, is researched, Molecular C5H7BrO3, CAS is 70-23-5, about Synthesis, Crystal Structure, and DFT Study of a New Compound 6-(2-Fluorophenyl)-N-(p-Tolyl)Imidazo[1,2-a]Pyridine-2-Carboxamide, the main research direction is imidazopyridine preparation conformer hydrogen bond HOMO crystal structure.Application In Synthesis of Ethyl 3-bromo-2-oxopropanoate.

6-(2-Fluorophenyl)-N-(p-tolyl)imidazo[1,2-a]pyridine-2-carboxamide is an organic intermediate having both functions of azabicyclo and amide groups. In this paper, the title compound is obtained by the ring closure reaction, the Suzuki reaction, the hydrolysis and amidation reactions. The structure of the compound is confirmed by FT-IR, lH NMR, 13C NMR spectroscopy, and MS. At the same time, a single crystal of the title compound is measured by X-ray diffraction and subjected to crystallog. and conformational analyses. The mol. structure is further calculated using d. functional theory (DFT) and compared with the X-ray diffraction value. The results of the conformation anal. indicate that the mol. structure optimized by DFT is consistent with the crystal structure determined by single crystal X-ray diffraction. In addition, the mol. electrostatic potential and frontier MOs of the title compound are further investigated using DFT, revealing some physicochem. properties of the compound

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Ghazvini, Maryam; Sheikholeslami-Farahani, Fatemeh; Hamedani, Naghmeh Faal; Shahvelayati, Ashraf Sadat; Rostami, Zohreh published the article 《Bio-Fe3O4 Magnetic Nanoparticles Promoted Green Synthesis of thioxo-1,3-Oxazole Derivatives: Study of Antimicrobial and Antioxidant Activity》. Keywords: furooxazole thioxo preparation green chem antioxidant antibacterial activity; bromo ketone isothiocyanate multicomponent reaction ferrimagnetic magnetite nanocatalyst; 2-thioxo-1; 3-oxazole; Alkyl (aryl) isothiocyanates; Alkyl bromides; Fe3O4-MNPs; Orange peel extract; antioxidant ability.They researched the compound: Ethyl 3-bromo-2-oxopropanoate( cas:70-23-5 ).SDS of cas: 70-23-5. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:70-23-5) here.

In this work, 1,3-oxazoles I (R = COOEt, 4-methoxyphenyl, 4-methylphenyl, 4-bromophenyl; R1 = t-Bu, 4-methoxyphenyl, 4-nitrophenyl; R2 = COOEt, 4-methoxyphenyl, 4-methylphenyl, 4-bromophenyl) were generated using the multicomponent reaction of α-bromo ketones R/R2C(O)CH2Br, alkyl (aryl) isothiocyanates R1N=C=S, sodium hydride and Fe3O4 MNPs in the water at room temperature in good yields. The nanoparticles generated via the biosynthesis method have potential value in different purposes, such as organic synthesis. To study the antioxidant ability of some synthesized thioxo-1,3-oxazoles I, diphenyl-picrylhydrazine (DPPH) radical trapping and power of ferric reduction testes are employed. Among the studied thioxo-1,3-oxazoles, compound I (R = R2 = COOEt; R1 = 4-nitrophenyl) have good power for radical trapping and reduction activity than the standard antioxidants such as BHT and TBHQ. In addition, the antimicrobial activity of some thioxo-1,3-oxazoles I was studied, employing the disk diffusion test on Gram-pos. bacteria and Gram-neg. bacteria. The results of the disk diffusion test showed that compounds I (R = R2 = COOEt, R1 = 4-nitrophenyl; R = R2 = COOEt, R1 = 4-methoxyphenyl; R = R2 = 4-methoxyphenyl, R1 = t-Bu; R = R2 = 4-bromophenyl R1 = 4-nitrophenyl) prevented bacterial growth. Without employing catalyst, these reactions have low yield and busy mixture The synthesis of compound I (R = R2 = COOEt; R1 = 4-methoxyphenyl) as sample reaction has a similar yield in the presence of ZnO-NPs and Fe3O4 MNPs (entry 20 and entry 30), but the removal of catalyst from the mixture of reaction after the completion of the reaction is comfortable in the presence of Fe3O4 MNPs. Some of the advantages of performing these reactions with the present procedure are to carry out these reactions in water as a green solvent and simple removal of catalyst.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Ethyl 3-bromo-2-oxopropanoate, is researched, Molecular C5H7BrO3, CAS is 70-23-5, about Wood ash biocatalyst as a novel green catalyst and its application for the synthesis of benzochromene derivatives.Application In Synthesis of Ethyl 3-bromo-2-oxopropanoate.

This study investigates the catalytic activity of wood ash as a heterogeneous catalyst for the synthesis of benzochromene derivatives I (R = Me, 4-methoxyphenyl, Ph, Et, 4-methylphenyl; R1 = 4-methoxyphenyl, C(O)OC2H5, 4-methylphenyl). Several wood ash catalysts, comprising calcium- and potassium-rich carbonates, were prepared from different natural resources under various combustion temperatures The prepared catalysts were characterized by Fourier transform IR, SEM, energy dispersive X-ray anal., transmission electron microscopy, and X-ray diffraction techniques. Catalytic efficiency of the resultant catalysts was tested in the synthesis of benzochromene derivatives I. The exptl. studies clarified that the catalyst prepared at 850 °C could efficiently expedite the formation of three-component synthesis of benzochromene derivatives I in water at 80 °C with high yields. Indeed, alkali, alk. metal, and metal oxides such as Al2O3, SiO2, MgO, CaO, and Fe2O3, are widely utilized as both catalyst and catalyst support in the heterogeneous catalytic processes. The prepared wood ash catalysts (possessing metal oxides, e.g., CuO, Al2O3, SiO2, and CaO) could effectively prompt the electrophilic activity of the carbonyl groups during the nucleophilic attack intermediate, enhancing the efficiency of the reactions.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

COA of Formula: C5H7BrO3. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Ethyl 3-bromo-2-oxopropanoate, is researched, Molecular C5H7BrO3, CAS is 70-23-5, about A selective “”turn-on”” sensor for recognizing In3+ and Zn2+ in respective systems based on imidazo[2,1-b]thiazole. Author is Xu, Yuankang; Zhao, Songfang; Zhang, Yanxia; Wang, Hanyu; Yang, Xiaofeng; Pei, Meishan; Zhang, Guangyou.

A new simple and easily synthesized multitarget sensor, (E)-N′-(4-(diethylamino)-2-hydroxybenzylidene)imidazo[2,1-b]thiazole-6-carbohydrazide (X), was designed and synthesized using imidazo[2,1-b]thiazole-6-carboxylic acid and 4-(diethylamino)-2-hydroxybenzaldehyde. X could be used as a sensor to detect In3+ in DMF-H2O buffer solution and detect Zn2+ in EtOH-H2O buffer solution through fluorescence enhancement with detection limits of 1.02 × 10-9 M and 5.5 × 10-9 M, resp. X exhibited an efficient “”off-on-off”” fluorescence behavior by cyclic addition of metal ions (In3+ and Zn2+) and EDTA. The stoichiometry between X and metal ions (In3+ and Zn2+) was 1 : 1. The binding mode and sensing mechanism of X with metal ions (In3+ and Zn2+) was verified by theor. calculations using Gaussian 09 based on B3LYP/6-31G(d) and B3LYP/LANL2DZ basis, resp. Moreover, X could be applied as a potential sensor for the quant. detection of In3+ and Zn2+ with a satisfactory recovery and relative standard deviation (RSD) in real water samples.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Synthesis, characterization, crystal structures, and the biological evaluation of 2-phenylthiazole derivatives as cholinesterase inhibitors, published in 2021-05-31, which mentions a compound: 70-23-5, Name is Ethyl 3-bromo-2-oxopropanoate, Molecular C5H7BrO3, Application of 70-23-5.

Four 2-phenylthiazole derivatives I [R = 4-methylpiperazin-1-yl, 2-morpholin-4-yl-Et, 3,5-dimethylpiperidin-1-yl, etc.] were synthesized, characterized and evaluated as cholinesterase inhibitors. The structures of the 2-phenylthiazole derivatives were confirmed by 1H and 13C NMR spectroscopy, single-crystal X-ray diffraction studies, and Hirshfeld surfaces anal. Hirshfeld surface anal. of the prepared compounds showed C-H···O intermol. interactions. The cholinesterase inhibition activities of the synthesized compounds were tested by Ellman’s method. Compound I [R = 3,5-dimethylpiperidin-1-yl] showed the best acetylcholinesterase inhibition activity with an IC50 value of 8.86μM and the best butyrylcholinesterase inhibition activity with an IC50 value of 1.03μM. A docking study demonstrated that the same compound interacted with the catalytic anionic site and peripheral anionic site of acetylcholinesterase and the catalytic anionic site of butyrylcholinesterase.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Xu, Yuankang; Wang, Hanyu; Zhao, Jinyan; Yang, Xiaofeng; Pei, Meishan; Zhang, Guangyou; Zhang, Yanxia published the article 《A dual functional fluorescent sensor for the detection of Al3+ and Zn2+ in different solvents》. Keywords: dual functional fluorescent sensor aluminum zinc detection solvent.They researched the compound: Ethyl 3-bromo-2-oxopropanoate( cas:70-23-5 ).Application of 70-23-5. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:70-23-5) here.

(E)-N’-((2-Hydroxynaphthalen-1-yl)methylene)imidazo[2,1-b]thiazole-6-carbohydrazide (X), a new fluorescent sensor, was designed and synthesized based on imidazo[2,1-b]thiazole and 2-hydroxy-1-naphthaldehyde, which could be used to detect Al3+ in methanol buffer solution and detect Zn2+ in ethanol buffer solution with detection limits of 1.45 × 10-7 M and 1.29 × 10-8 M, resp. X showed high sensitivity and selectivity towards Al3+ and Zn2+ in the presence of other metal ions. The fluorescence intensity of X was reversible even after six cycles with the sequentially alternative addition of metal ions (Al3+ and Zn2+) and PPi, showing an efficient off-on-off fluorescence behavior. The complexation ratio of X to Al3+ and Zn2+ was 1 : 1, which was proved by mass spectrometry and the B-H equation. The binding mode and sensing mechanism of X with metal ions (Al3+ and Zn2+) were verified by DFT/TDDFT calculations using Gaussian 09 based on the B3LYP/6-31G(d) basis set.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Safety of Ethyl 3-bromo-2-oxopropanoate. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Ethyl 3-bromo-2-oxopropanoate, is researched, Molecular C5H7BrO3, CAS is 70-23-5, about Elastase inhibitor cyclotheonellazole A: Total synthesis and in vivo biological evaluation for acute lung injury. Author is Cui, Yingjun; Zhang, Mengyi; Xu, Honglei; Zhang, Tingrong; Zhang, Songming; Zhao, Xiuhe; Jiang, Peng; Li, Jing; Ye, Baijun; Sun, Yuanjun; Wang, Mukuo; Deng, Yangping; Meng, Qing; Liu, Yang; Fu, Qiang; Lin, Jianping; Wang, Liang; Chen, Yue.

Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is one of the most common complications in COVID-19. Elastase has been recognized as an important target to prevent ALI/ARDS in the patient of COVID-19. Cyclotheonellazole A (CTL-A) is a natural macrocyclic peptide reported to be a potent elastase inhibitor. Herein, we completed the first total synthesis of CTL-A in 24 linear steps. The key reactions include three-component MAC reactions and two late-stage oxidations We also provided seven CTL-A analogs and elucidated preliminary structure-activity relationships. The in vivo ALI mouse model further suggested that CTL-A alleviated acute lung injury with reductions in lung edema and pathol. deterioration, which is better than sivelestat, one approved elastase inhibitor. The activity of CTL-A against elastase, along with its cellular safety and well-established synthetic route, warrants further investigation of CTL-A as a candidate against COVID-19 pathogeneses.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem