Category: 70-23-5

SDS of cas: 70-23-5. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Ethyl 3-bromo-2-oxopropanoate, is researched, Molecular C5H7BrO3, CAS is 70-23-5, about A new fluorescent probe based on imidazole[2,1-b]benzothiazole for sensitive and selective detection of Cu2+. Author is Wang, Hanyu; Zhao, Songfang; Xu, Yuankang; Li, Linlin; Li, Bing; Pei, Meishan; Zhang, Guangyou.

A simple fluorescent chemosensor WS1 (N’-[(Z)-1H-indazol-3-ylmethylidene]imidazo [2,1-b] [1,3]benzothiazole-2-carbohydrazide) based on imidazole [2,1-b]benzothiazole was designed and synthesized. The probe showed specific recognition towards Cu2+ through colorimetric and “”turn-off”” fluorescence response in MeOH/H2O (9:1 V/V) buffer solution (10 mM Tris, pH = 7.4) with detection limit of 4.32 × 10-8 M. In addition, WS1 was a reversible fluorescence probe for the detection of Cu2+, the fluorescence intensity recovered to the similar state of free WS1 as PPi was added. And it showed a favorable potency for actual water monitoring. The proposed binding mode of WS1 with Cu2+ was verified by DFT calculation using Gaussian 09.

The article 《A new fluorescent probe based on imidazole[2,1-b]benzothiazole for sensitive and selective detection of Cu2+》 also mentions many details about this compound(70-23-5)SDS of cas: 70-23-5, you can pay attention to it, because details determine success or failure

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Safety of Ethyl 3-bromo-2-oxopropanoate. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Ethyl 3-bromo-2-oxopropanoate, is researched, Molecular C5H7BrO3, CAS is 70-23-5, about Synthesis of the deacetoxytubuvaline fragment of pretubulysin and its lipophilic analogs for enhanced permeability in cancer cell lines. Author is Reddy, Ramesh B.; Dudhe, Premansh; Chelvam, Venkatesh.

In the last two decades, tubulysins have emerged as alternatives to microtubule depolymerizing agents such as colchicine and vinblastine, which are well-established anticancer agents. However, the complex structure of tubulysins has always posed a challenge for synthetic chemists to scale up the production of these compounds We report a new strategy for the practical gram-scale synthesis of a (4R)-4-[( tert-butoxycarbonyl)amino]-5-methylhexanoic acid through regioselective cleavage of a chiral aziridine ring with a vinyl Grignard reagent to afford tert-Bu [(1R)-1-isopropylbut-3-en-1-yl]carbamate, which was subjected to regioselective hydroboration-oxidation with 9-BBN. The resulting (4R)-4-[( tert-butoxycarbonyl)amino]-5-methylhexanoic acid was successfully transformed into the deacetoxytubuvaline fragment of pretubulysin or its highly lipophilic methyl-substituted thiazole and oxazole analogs for incorporation into pretubulysins. Increasing the lipophilicity of tubulysin or pretubulysin mols. should enhance their cell permeability and cytotoxicity in cancer cell lines.

The article 《Synthesis of the deacetoxytubuvaline fragment of pretubulysin and its lipophilic analogs for enhanced permeability in cancer cell lines》 also mentions many details about this compound(70-23-5)Safety of Ethyl 3-bromo-2-oxopropanoate, you can pay attention to it, because details determine success or failure

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Savari, Mehdi; Varasteh-Moradi, Ali; Sayyed-Alangi, S. Zahra; Hossaini, Zinatossadat; Zafarmehrabian, Ramin researched the compound: Ethyl 3-bromo-2-oxopropanoate( cas:70-23-5 ).COA of Formula: C5H7BrO3.They published the article 《Ag/Fe3O4/TiO2@MWCNTs as a reusable organometallic nanocatalyst promoted green synthesis of new pyridobenzoazepines: Study of biological activity and reduction of organic pollutants》 about this compound( cas:70-23-5 ) in Applied Organometallic Chemistry. Keywords: magnetic nanocatalyst preparation; pyridobenzoazepine green preparation antibacterial radical scavenger antioxidant; isatoic anhydride alpha haloketone alkyne epoxide magnetic nanocatalyst multicomponent. We’ll tell you more about this compound (cas:70-23-5).

In this research, Ag/Fe3O4/TiO2@MWCNTs magnetic nanocomposites synthesized using water extract of Spinacia oleracea leaves, and the high performance of synthesized catalyst was confirmed by employing it in the multicomponent reaction of isatoic anhydride, N-methylimidazole, α-haloketones, electron-deficient acetylenic compounds, ammonium acetate, and Me epoxide in water at ambient temperature for the preparation of new pyridobenzoazepine derivatives such as I [X = H, Me, NO2, etc.; R1 = Me, Et; R2 = CO2Et, 4-MeC6H4, 4-MeOC6H4, etc.] in high yields. Also, the catalytic activity of the green synthesized Ag/Fe3O4/TiO2@MWCNTs was evaluated in the reduction of organic pollutants such as 4-nitrophenol in water at mild conditions. The results indicated that the biosynthesized magnetic nanocomposites (MNCs) have very high and effective catalytic activity for organic pollutants within few seconds. The synthesized compounds have OH group in their structure and for this reason might be showed good antioxidant activity. Also, employing Gram-pos. and Gram-neg. bacteria in the disk diffusion procedure confirmed antimicrobial effect of the some pyridobenzoazepine derivatives The results showed that synthesized compounds prevented the bacterial growth. This used procedure for preparation of pyridobenzoazepine derivatives have some advantages such as low reaction time, product with high yields, and simple separation of catalyst and products.

After consulting a lot of data, we found that this compound(70-23-5)COA of Formula: C5H7BrO3 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: Ethyl 3-bromo-2-oxopropanoate(SMILESS: O=C(OCC)C(CBr)=O,cas:70-23-5) is researched.Electric Literature of C5H2Cl2N4. The article 《Design, Synthesis, and Evaluation of the Antifungal Activity of Novel Pyrazole-Thiazole Carboxamides as Succinate Dehydrogenase Inhibitors》 in relation to this compound, is published in Journal of Agricultural and Food Chemistry. Let’s take a look at the latest research on this compound (cas:70-23-5).

Succinate dehydrogenase (SDH) is regarded as a promising target for fungicide discovery. To continue our ongoing studies on the discovery of novel SDH inhibitors as fungicides, novel pyrazole-thiazole carboxamides were designed, synthesized, and evaluated for their antifungal activity. The results indicated that compounds 9ac, 9bf, and 9cb showed excellent in vitro activities against Rhizoctonia cerealis with EC50 values from 1.1 to 4.9 mg/L, superior to that of the com. fungicide thifluzamide (EC50 = 23.1 mg/L). Compound 9cd (EC50 = 0.8 mg/L) was far more active than thifluzamide (EC50 = 4.9 mg/L) against Sclerotinia sclerotiorum. Compound 9ac exhibited promising in vivo activity against Rhizoctonia solani (90% at 10 mg/L), which was better than that of thifluzamide (80% at 10 mg/L). The field experiment showed that compound 9ac had 74.4% efficacy against Rhizoctonia solani on the 15th day after two consecutive sprayings at an application rate of 4.80 g a.i./667 m2, which was close to that of thifluzamide (83.3%). Furthermore, mol. docking explained the possible binding mode of compound 9ac in the RcSDH active site. Our studies indicated that the pyrazole-thiazole carboxamide hybrid is a new scaffold of SDH inhibitors.

After consulting a lot of data, we found that this compound(70-23-5)Computed Properties of C5H7BrO3 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

COA of Formula: C5H7BrO3. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Ethyl 3-bromo-2-oxopropanoate, is researched, Molecular C5H7BrO3, CAS is 70-23-5, about Fragment-Based Ligand Discovery Using Protein-Observed 19F NMR: A Second Semester Organic Chemistry CURE Project. Author is Bur, Scott K.; Pomerantz, William C. K.; Bade, Morgan L.; Gee, Clifford T..

Curriculum-based undergraduate research experiences (CUREs) have been shown to increase student retention in STEM fields and are starting to become more widely adopted in chem. curricula. Here we describe a 10-wk CURE that is suitable for a second-semester organic chem. laboratory course. Students synthesize small mols. and use protein-observed 19F (PrOF) NMR to assess the small mol.’s binding affinity to a target protein. The research project introduced students to multistep organic synthesis, structure-activity relationship studies, quant. biophys. measurements (measuring Kd from PrOF NMR experiments), and scientific literacy. Docking experiments could be added to help students understand how changes in a ligand structure may affect binding to a protein. Assessment using the CURE survey indicates self-perceived skill gains from the course that exceed gains measured in a traditional and an inquiry-based laboratory experience. Given the speed of the binding experiment and the alignment of the synthetic methods with a second-semester organic chem. laboratory course, a PrOF NMR fragment-based ligand discovery lab can be readily implemented in the undergraduate chem. curriculum.

After consulting a lot of data, we found that this compound(70-23-5)COA of Formula: C5H7BrO3 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, RSC Advances called The design, synthesis, and in vitro trypanocidal and leishmanicidal activities of 1,3-thiazole and 4-thiazolidinone ester derivatives, Author is Haroon, Muhammad; de Barros Dias, Mabilly Cox Holanda; Santos, Aline Caroline da Silva; Pereira, Valeria Rego Alves; Barros Freitas, Luiz Alberto; Balbinot, Rodolfo Bento; Kaplum, Vanessa; Nakamura, Celso Vataru; Alves, Luiz Carlos; Brayner, Fabio Andre; Leite, Ana Cristina Lima; Akhtar, Tashfeen, which mentions a compound: 70-23-5, SMILESS is O=C(OCC)C(CBr)=O, Molecular C5H7BrO3, Recommanded Product: Ethyl 3-bromo-2-oxopropanoate.

Given this, novel 1,3-thiazoles I (Ar = Ph, 3-chlorophenyl, furan-2-yl, etc.; R = H, Me) and 4-thiazolidinones II (R1 = (phenylmethylidene)aminyl, [(4-hydroxy-3-methoxyphenyl)methylidene]aminyl, 1,2,3,4-tetrahydronaphthalen-1-iminyl, etc.; R2 = Me, Et) using bioisosteric and esterification strategies to develop improved and safer drug candidates were synthesized. Then, in vitro assays were performed, against Leishmania infantum and Leishmania amazonensis promastigotes, Trypanosoma cruzi trypomastigotes and amastigotes, for selected compounds I and II to determine IC50 and SI, with cytotoxicity on LLC-MK2 cell lines. Overall, 1,3-thiazoles I exhibited better trypanocidal activity than 4-thiazolidinones II. The compound I[Ar = 2-bromophenyl, R = H] (III), an ortho-bromobenzylidene-substituted 1,3-thiazole (IC50 = 0.83μM), is the most potent of them all. In addition, compounds I and II had negligible cytotoxicity in mammalian cells (CC50 values > 50μM). Also noteworthy is the examination of the cell death mechanism of T. cruzi, which showed that compound III induced necrosis and apoptosis in the parasite. SEM anal. demonstrated that the treatment of Trypanosoma cruzi trypomastigote cells with the compound III at different IC50 concentrations promoted alterations in the shape, flagella and body surface, inducing parasite death. Together, the data revealed a novel series of 1,3-thiazole structure-based compounds I with promising activity against Trypanosoma cruzi and Leishmania spp., broadening ways for scaffold optimization.

Although many compounds look similar to this compound(70-23-5)Recommanded Product: Ethyl 3-bromo-2-oxopropanoate, numerous studies have shown that this compound(SMILES:O=C(OCC)C(CBr)=O), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Green synthesis of pyrido[2,1-a]isoquinolines and pyrido[1,2-a]quinolines using Fe3O4-MNPs as efficient nanocatalyst: Study of antioxidant activity, published in 2020, which mentions a compound: 70-23-5, Name is Ethyl 3-bromo-2-oxopropanoate, Molecular C5H7BrO3, Category: oxazolidine.

In this work, synthesis of pyrido[2,1-a]isoquinolines I (R = COOEt, 4-MeOC6H4, 4-MeC6H4, 4-BrC6H4, 4-O2NC6H4) and pyrido[1,2-a]quinolines II (R1 = COOEt, 4-MeOC6H4, 4-MeC6H4) in excellent yields using multicomponent reaction of phthalaldehyde, Me amine, Me malonyl chloride, alkyl bromides, and triphenylphosphine in the presence of catalytic amount of Fe3O4-MNPs and aqueous sodium hydroxide at 80° was investigated. The reduction of ferric chloride solution with Clover Leaf water extract was used for the synthesis of magnetic iron oxide nanoparticles (Fe3O4-MNPs) as a green method. As well, antioxidant activity was studied for the some newly synthesized compounds such as I (R = COOEt, 4-MeC6H4), II (R1 = 4-MeOC6H4, 4-MeC6H4) using the DPPH radical trapping, reducing of ferric ion experiments and comparing results with synthetic antioxidants (TBHQ and BHT). From the results, the above compounds showed good DPPH radical trapping and excellent reducing strength of ferric ion.

Although many compounds look similar to this compound(70-23-5)Category: oxazolidine, numerous studies have shown that this compound(SMILES:O=C(OCC)C(CBr)=O), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Molbank called Diethyl pyrrole-2,5-dicarboxylate, Author is Aitken, R. Alan; Bloomfield, Charles; McGeachie, Liam J. R.; Slawin, Alexandra M. Z., which mentions a compound: 70-23-5, SMILESS is O=C(OCC)C(CBr)=O, Molecular C5H7BrO3, Related Products of 70-23-5.

The di-Et pyrrole-2,5-dicarboxylate were obtained in moderate yield by a new and unexpected base-induced ring contraction from a 3,5-di-Et 2H-1,4-thiazine-3,5-dicarboxylate precursor. Its X-ray structure showing hydrogen bonded dimers was compared with those of other crystallog. characterized di-Et pyrrole-2,5-dicarboxylate.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 70-23-5, is researched, Molecular C5H7BrO3, about Green production and antioxidant activity study of new pyrrolo[2,1-a]isoquinolines, the main research direction is phthaldehyde primary amine bromoalkane acetylene carboxylate four component reaction; pyrroloisoquinoline preparation antioxidant green chem; chromenoindolizine preparation; pyranopyrroloisoquinoline preparation.Category: oxazolidine.

In current research, pyrrolo[2,1-a]isoquinolines, compounds I [R1 = CN; R2 = CO2Et, 4-BrC6H4, etc.; R3 = H, CO2Me, CO2Et; R4 = Me, Et; X1 = H, Me, MeO; X2 = H, Me] were synthesized via a new process of four-component reaction of phthalaldehyde or its derivatives, primary amines, alkyl bromides, activated acetylenic compounds and potassium fluoride/Clinoptilolite nanoparticles (KF/CP NPs) under solvent-free conditions at room temperature Also, Diels-Alder reactions took place in the reaction of synthesized pyrrolo[2,1-a]isoquinoline derivatives, activated acetylenic compounds and triphenylphosphine in the presence of KF/CP NPs under solvent-free conditions at room temperature As well, antioxidation property of some prepared pyrrolo[2,1-a]isoquinolines were investigated by employing trapping of diphenyl-picrylhydrazine (DPPH) radical and ability of ferric reduction experiment Among investigated compounds, compounds I [R1 = CN, R2 = 4-MeC6H4, R3 = CO2Me, R4 = Me, X1 = H, X2 = Me] have good results relative to BHT and TBHQ as standard antioxidant. Reported method has good rate of reaction, product with high efficiency and simple removal of catalyst from mixture of reaction. In these reactions, KF/Clinoptilolite nanoparticles show a satisfactory recyclable activity.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Soleimani-Amiri, Somayeh; Shafaei, Faezeh; Varasteh Moradi, Ali; Gholami-Orimi, Fathali; Rostami, Zohreh published the article 《A Novel Synthesis and Antioxidant Evaluation of Functionalized [1,3]-Oxazoles Using Fe3O4-Magnetic Nanoparticles》. Keywords: cyclopenta oxazole thione green preparation radical trapping ferric reduction; oxazole thione preparation bromo ketone isothiocyanate cyclization; magnetic iron oxide nanoparticle catalyst preparation.They researched the compound: Ethyl 3-bromo-2-oxopropanoate( cas:70-23-5 ).Synthetic Route of C5H7BrO3. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:70-23-5) here.

In this research, green procedure was employed for biosynthesis of magnetic nanoparticles of iron oxide (Fe3O4-MNPs) by reduction of ferric chloride solution with Orange peel water extract Also, dihydro-2H-cyclopenta[d][1,3]oxazoles I (R = CO2Et, 4-MeOC6H4, 4-MeC6H4, 4-BrC6H4; R1 = t-Bu, 4-MeOC6H4, 4-O2NC6H4; R2 = Me, Et; R3 = CO2Et, 4-MeOC6H4, 4-MeC6H4) were generated through multi-component reaction of 1,3-oxazole-2(3H)-thione, dialkyl acetylenedicarboxylates, α-haloketones, and Fe3O4-MNPs as catalyst at ambient temperature in good yield. Initially, 1,3-oxazole-2(3H)-thione derivatives as one of the precursors are produced through the reaction of alkyl bromides, isothiocyanate, sodium hydride, and Fe3O4-MNPs as catalyst water at ambient temperature in 83-95% yields. Also, diphenyl-picrylhydrazine radical trapping and ferric reduction activity potential assays are used for evaluation of antioxidant activity of some synthesized compounds Among investigated compounds, I (R = CO2Et; R1 = 4-O2NC6H4; R2 = Me; R3 = 4-MeOC6H4) has good power for radical trapping activity and I (R = 4-MeOC6H4; R1 = t-Bu; R2 = Me; R3 = 4-MeC6H4) has good reduction power to butylated hydroxytoluene and 2-tert-butylhydroquinone.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem