Category: 70-23-5

Zeng, Hongyun; Zhang, Jun-gan; Hong, Wei published an article about the compound: Ethyl 3-bromo-2-oxopropanoate( cas:70-23-5,SMILESS:O=C(OCC)C(CBr)=O ).HPLC of Formula: 70-23-5. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:70-23-5) through the article.

Thiazole ring is an important five-membered aromatic heterocyclic ring, and its derivatives have various biol. activities and are widely used in medicine. The synthesis of 2,5-diarylthiazole derivatives by acylation, thiolation, cyclization and Heck reaction using inexpensive and readily available substituted benzoic acid as raw materials was developed. The key point was to optimize the Heck reaction conditions and explore the possible reaction mechanism. The method has mild reaction conditions, simple operation, and good substrate universality, which provides a new direction for the synthesis of 2,5-diaryl substituted thiazoles.

This compound(Ethyl 3-bromo-2-oxopropanoate)HPLC of Formula: 70-23-5 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

SDS of cas: 70-23-5. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: Ethyl 3-bromo-2-oxopropanoate, is researched, Molecular C5H7BrO3, CAS is 70-23-5, about Synthesis of tubuvaline (Tuv) fragment of tubulysin via diastereoselective dihydroxylation of homoallylamine.

Tubulysins are natural anticancer mols. that directly bind and inhibit tubulin polymerization in actively dividing cells leading to apoptosis and cell death. Structurally, tubulysins are linear tetrapeptides, constituted by a natural amino acid (Ile) and three non-canonical amino acids (Mep, Tuv, and Tup). Herein, we report a convenient strategy for the practical synthesis of tubuvaline fragment of tubulysin natural products. In this approach, we describe the regioselective ring opening of a chiral aziridine with vinyl Grignard reagent to obtain (R)-tert-butyl(2-methylhex-5-en-3-yl)(tosyl)carbamate which was further subjected to Sharpless asym. dihydroxylation with AD-mix-β resulting in the formation of (2 R,4R)-4-((tert-butoxycarbonyl)amino)-2-(methoxymethoxy)-5-methylhexanoic acid that was finally transformed to tubuvaline by heterocyclization.

This compound(Ethyl 3-bromo-2-oxopropanoate)SDS of cas: 70-23-5 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: Ethyl 3-bromo-2-oxopropanoate(SMILESS: O=C(OCC)C(CBr)=O,cas:70-23-5) is researched.Recommanded Product: Ethyl 3-bromo-2-oxopropanoate. The article 《KF/Clinoptilolite Nanoparticles as a Heterogeneous Catalyst for Green Synthesis of pyrido[2,1-a]isoquinolines using Four-Component Reaction of Alkyl Bromides》 in relation to this compound, is published in Combinatorial Chemistry & High Throughput Screening. Let’s take a look at the latest research on this compound (cas:70-23-5).

KF/Clinoptilolite nanoparticles were employed as a heterogeneous catalyst for the preparation of pyrido[2,1-a]isoquinoline derivatives I [R = CO2Et, Ph, 4-MeC6H4, etc.; R1 = CO2Et, 4-MeC6H4, 4-MeOC6H4; R2 = Me, Et] through a four-component reaction of isoquinoline, two different alkyl bromides and electron deficient internal alkynes at ambient temperature in water as green solvent. In this research, (2,2-diphenyl-1-picrylhydrazyl) radical trapping and reducing potential of ferric ion experiments was used for determining antioxidant activity of some newly synthesized compounds I [R = Ph, R1 = CO2Et, R2 = Me; R = 4-MeOC6H4, R1 = CO2Et, R2 = Me; R = CO2Et, R1 = 4-MeOC6H4, R2 = Et; R = CO2Et, R1 = CO2Et, R2 = Me] and comparing results with synthetic antioxidants (TBHQ and BHT). Above compounds displayed trace DPPH radical trapping and excellent reducing power of ferric ion. Furthermore, the power of some prepared compounds against Gram-pos. and Gram-neg. bacteria was proved by employing the disk dispersion experiment The obtained results of disk diffusion test showed that compounds I [R = Ph, R1 = CO2Et, R2 = Me; R = 4-O2NC6H4, R1 = CO2Et, R3 = Me; R = CO2Et, R1 = 4-MeC6H4, R2 = Me] prevented the bacterial growth.

This compound(Ethyl 3-bromo-2-oxopropanoate)Electric Literature of C5H7BrO3 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Journal of Heterocyclic Chemistry called ZnO nanorods as efficient catalyst for the green synthesis of thiophene derivatives: Investigation of antioxidant and antimicrobial activity, Author is Hamedani, Naghmeh Faal; Ghazvini, Maryam; Sheikholeslami-Farahani, Fatemeh; Bagherian-Jamnani, Mohammad Taghi, which mentions a compound: 70-23-5, SMILESS is O=C(OCC)C(CBr)=O, Molecular C5H7BrO3, Recommanded Product: Ethyl 3-bromo-2-oxopropanoate.

In this work, thiophene derivatives I [R = 4-H3CC6H4, 4-H3COC6H4, 4-O2NC6H4, CH3CH2OC(O); R1 = Me, Et; R2 = 4-H3CC6H4, 4-H3COC6H4] were synthesized in good yields via multicomponent reaction of isoquinoline, alkyl bromides BrCH2C(O)R, activated acetylenic compounds R1OC(O)CCC(O)OR1, isothiocyanates R2N=C=S, and catalytic amounts of ZnO nanorods (NRs) at room temperature under solvent-free conditions. This procedure for the synthesis of thiophene derivatives I is green, easy, and simple with excellent yield. In addition, DPPH radical scavenging and ferric reduction power experiment has been studied for the evaluation of the antioxidant activity of some prepared thiophenes, for example, I [R = CH3CH2OC(O), R1 = Me, R2 = 4-H3COC6H4 (A); R = 4-O2NC6H4, R1 = Me, R2 = 4-H3CC6H4 (B); R = CH3CH2OC(O), R1 = Me, R2 = 4-H3CC6H4 (C); R = CH3CH2OC(O), R1 = Et, R2 = 4-H3COC6H4 (D)]. As outcome, the compound (B) exhibited a noteworthy radical trapping activity and excellent reducing ability than synthetic antioxidants such as butylated hydroxytoluene (BHT) and 2-tertbutylhydroquinone (TBHQ). Moreover, the antimicrobial activity of some synthesized thiophenes was confirmed by employing the disk diffusion test on Gram-pos. and Gram-neg. bacteria. The obtained results of disk diffusion test showed that compounds (A), (B), (C), and (D) prevented bacterial growth.

This compound(Ethyl 3-bromo-2-oxopropanoate)Recommanded Product: Ethyl 3-bromo-2-oxopropanoate was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Synthetic Route of C5H7BrO3. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: Ethyl 3-bromo-2-oxopropanoate, is researched, Molecular C5H7BrO3, CAS is 70-23-5, about A Highly Selective “”Turn-On”” Fluorescent Sensor for Aluminum Ion Detection in Aqueous Solution Based on Imidazo[2,1-b]thiazole Schiff Base. Author is Wang, Haibin; Xu, Xin; Yin, Jichen; Zhang, Zhifeng; Xue, Lei.

Low sensitivity of fluorescent sensors with “”turn-off”” response for identifying Al3+ has limited their wide application in the field of ion sensing. Herein, this paper reports a novel fluorescence sensor (L) endowing with “”turn-on”” fluorescence response based on imidazo[2,1-b]thiazole for recognizing Al3+ in aqueous solutions Results show that the L exhibits high selectivity and sensitivity with “”turn-on”” fluorescence response towards Al3+, but also has strong anti-interference to other common ions. In addition, the excellent color change can be distinguished by naked eyes under UV light and the test papers show great potential for detecting Al3+ in tap water. The supposed sensing mechanism of L to Al3+ could be attributed to the inhibition of photo-induced electron transfer (PET) and chelation-enhanced fluorescence (CHEF). Such a novel design pathway is expected to offer helpful guidance for fabricating various sensors with “”turn-on””; fluorescence response.

This compound(Ethyl 3-bromo-2-oxopropanoate)Synthetic Route of C5H7BrO3 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Xu, Yuankang; Wang, Hanyu; Zhao, Jinyan; Yang, Xiaofeng; Pei, Meishan; Zhang, Guangyou; Zhang, Yanxia; Lin, Li published an article about the compound: Ethyl 3-bromo-2-oxopropanoate( cas:70-23-5,SMILESS:O=C(OCC)C(CBr)=O ).Related Products of 70-23-5. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:70-23-5) through the article.

A simple fluorescent schiff base, X, based on imidazo[2,1-b]thiazole-6-carboxylic acid and 3-ethoxy-2-hydroxybenzaldehyde, was designed and synthesized for detection of Zn2+ and PPi. X showed excellent sensitivity and selectivity toward Zn2+ by exhibiting a large fluorescence enhancement (about 42 times). The binding ratio of the X and Zn2+ was 1:1 confirmed by mass spectral anal. and Job′s plot and the association constant between X and Zn2+ was calculated to be 2.2 × 105 M-1. The detection limit was as low as 1.2 × 10-9 M. Moreover, the X[Zn2+] complex could be used as a sensor to detect PPi sensitively and the detection limit was 1.9 × 10-9 M. Furthermore, the fluorescent signals of X were utilized to construct an INHIBIT logic gate at the mol. level. The reason of fluorescence enhancement of X toward Zn2+ was verified by d. functional theory (DFT) and time-dependent d. functional theory (TDDFT) calculations using Gaussian 09.

《A simple fluorescent schiff base for sequential detection of Zn2+ and PPi based on imidazo[2,1-b]thiazole》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(Ethyl 3-bromo-2-oxopropanoate)Related Products of 70-23-5.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Computed Properties of C5H7BrO3. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: Ethyl 3-bromo-2-oxopropanoate, is researched, Molecular C5H7BrO3, CAS is 70-23-5, about Addition of malonic esters to azoalkenes generated in situ from α-bromo- and α-chlorohydrazones. Author is Kokuev, Aleksandr O.; Ioffe, Sema L.; Sukhorukov, Alexey Yu..

Michael addition of malonic esters to azoalkenes, generated in situ from α-bromo- and α-chlorohydrazones, has been accomplished. Both aliphatic and aromatic substrates bearing different functional groups were tolerated. The use of a strong base (sodium hydride) for generation of azoalkenes and deprotonation of malonate was found to be essential for a successful coupling. Synthetic potential of the obtained β-hydrazonoalkylmalonates RNHN:C(R1)CH2CH(CO2R2)2 [R = Ac, Boc, Cbz, 2,4-(O2N)2C6H3; R1 = t-Bu, EtO2C, Ph, 2-naphthyl, 2-thienyl, etc.; R2 = Me, PhCH2] was demonstrated by their smooth conversion into five- and six-membered N-heterocycles, functionalized hydrazides, 2-(2-oxo-2-arylethyl)malonates and 2-arylethylmalonates.

《Addition of malonic esters to azoalkenes generated in situ from α-bromo- and α-chlorohydrazones》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(Ethyl 3-bromo-2-oxopropanoate)Computed Properties of C5H7BrO3.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Reference of Ethyl 3-bromo-2-oxopropanoate. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Ethyl 3-bromo-2-oxopropanoate, is researched, Molecular C5H7BrO3, CAS is 70-23-5, about Comparative evaluation of the inhibitory potential of synthetic N-heterocycles, Cu/Fe3O4@SiO2 nanocomposites and some natural products against non-resistant and antibiotic-resistant Acinetobacter baumannii. Author is Mardaneh, Jalal; Beyzaei, Hamid; Hashemi, Seyed Hadi; Ghasemi, Behzad; Rahdar, Abbas.

Acinetobacter baumannii is a common infectious agent in hospitals. New antimicrobial agents are identified and prepared to combat these bacterial pathogens. In this context, the blocking potentials of a series of synthesized N-heterocyclic compounds, Cu/Fe3O4@SiO2 nanocomposites, glycine, poly-L-lysine, nisin and hydroalcoholic extracts of Trachyspermum ammi, Curcuma longa and green tea catechins were evaluated against non-resistant and multidrug-resistant strains of A. baumannii. Solutions of heterocyclic derivatives and hydroalcoholic extracts of Trachyspermum ammi, Curcuma longa and green tea catechins were prepared at initial concentration of 10240μg ml-1 in 10% DMSO. Other compounds were dissolved in water at the same concentrations Their in vitro inhibitory activity was assessed by determination of IZD, MIC and MBC values. Glycine, poly-L-lysine, nisin, Curcuma longa and green tea catechins extracts, and thiazoles 3a, 3d and 3f were ineffective at their initial concentrations Heterocyclic derivatives 7a-f, 3c, 3e and 3h, Cu/Fe3O4@SiO2 nanocomposites and Trachyspermum ammi extract could block the growth of bacterial strains with IZDs (7.40-15.51 mm), MICs (32-1024μg ml-1) and MBCs (128-2048μg ml-1). Among synthetic chems. and natural products, the best antimicrobial effects were recorded with (E)-2-(5-acetyl-4-methylthiazol-2-yl)-2-(thiazolidin-2-ylidene)acetonitrile (7b) and the extract of Trachyspermum ammi. It is imperative that their toxic and histopathol. effects were assessed in future researches. It is predicted that the essential oil of Trachyspermum ammi will improve its antibacterial activities.

Different reactions of this compound(Ethyl 3-bromo-2-oxopropanoate)Reference of Ethyl 3-bromo-2-oxopropanoate require different conditions, so the reaction conditions are very important.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Safety of Ethyl 3-bromo-2-oxopropanoate. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: Ethyl 3-bromo-2-oxopropanoate, is researched, Molecular C5H7BrO3, CAS is 70-23-5, about Fe3O4 MNPs as a green catalyst for syntheses of functionalized [1,3]-oxazole and 1H-pyrrolo-[1,3]-oxazole derivatives and evaluation of their antioxidant activity.

Iron oxide magnetic nanoparticles (Fe3O4MNPs) were synthesized in a green biosynthetic manner using aqueous extract of clover leaves. Fe3O4MNPs were applied as a magnetically separable nanocatalyst for the green syntheses of functionalized [1,3]-oxazoles I [R = COOEt, 4-MeC6H4, 4-MeOC6H4, 4-O2NC6H4, 4-BrC6H4] and 1H-pyrrolo-[1,3]-oxazoles II [R1 = COOEt, 4-MeC6H4, 4-MeOC6H4, 4-O2NC6H4, 4-BrC6H4; R2 = Me, Et; R3 = COOEt, 4-MeC6H4, 4-MeOC6H4] as promising antioxidant compounds in excellent yields at 50° and room temperature, resp. The antioxidant activities of the most stable compounds I [R = 4-MeOC6H4, 4-O2NC6H4] and 1H-pyrrolo-[1,3]-oxazoles II [R1 = R3 = COOEt, 4-MeOC6H4; R2 = Me] were evaluated by both 2,2-diphenyl-1-picrylhydrazyl radical scavenging and ferric reduction activity potential assays. Compound I [R = 4-MeOC6H4] was shown a remarkable radical scavenging activity, and II [R1 = R3 = CO2Et, R2 = Me] was shown very good reducing activity relative to standards (BHT and TBHQ).

The article 《Fe3O4 MNPs as a green catalyst for syntheses of functionalized [1,3]-oxazole and 1H-pyrrolo-[1,3]-oxazole derivatives and evaluation of their antioxidant activity》 also mentions many details about this compound(70-23-5)Safety of Ethyl 3-bromo-2-oxopropanoate, you can pay attention to it or contacet with the author([email protected]) to get more information.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Palladium-catalysed imidoylative spirocyclization of 3-(2-isocyanoethyl)indoles, published in 2021, which mentions a compound: 70-23-5, Name is Ethyl 3-bromo-2-oxopropanoate, Molecular C5H7BrO3, Electric Literature of C5H7BrO3.

A palladium-catalyzed construction of spiroindolines through dearomative spirocyclization of 3-(2-isocyanoethyl)indoles was developed. 2′-Aryl-, vinyl-, and alkyl-substituted spiroindolines were accessed under mild conditions with excellent functional group tolerance. C1-tethered oxindole- and indole-spiroindoline bisheterocycles were generated in high yields via alkene/allene insertion and an imidoylative spirocyclization cascade. Addnl., a tandem dearomatization of two different indoles was realized with N-(2-bromobenzoyl)indoles as the electrophilic coupling partner of 3-(2-isocyanoethyl)indoles, affording polyindoline – spiroindoline bisheterocyclic scaffolds conveniently. Under the catalysis of Pd(OAc)2 and a spinol-derived phosphoramidite ligand, chiral spiroindolines were successfully accessed with up to 95% yield and 85% ee.

The article 《Palladium-catalysed imidoylative spirocyclization of 3-(2-isocyanoethyl)indoles》 also mentions many details about this compound(70-23-5)Electric Literature of C5H7BrO3, you can pay attention to it or contacet with the author([email protected]; [email protected]; [email protected]; [email protected]; [email protected]; [email protected]) to get more information.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem