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The present invention provides a novel piperidine derivative and a tachykinin receptor antagonist containing same, as well as a compound represented by the formula:wherein R1 is carbamoylmethyl, methylsulfonylethylcarbonyl and the like; R2 is methyl or cyclopropyl; R3 is a hydrogen atom or methyl; R4 is a chlorine atom or trifluoromethyl; R5 is a chlorine atom or trifluoromethyl; and a group represented by the formula:is a group represented by the formula:wherein R6 is a hydrogen atom, methyl, ethyl or isopropyl; R7 is a hydrogen atom, methyl or a chlorine atom; and R8 is a hydrogen atom, a fluorine atom, a chlorine atom or methyl; or 3-methylthiophen-2-yl, and a salt thereof.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H1323NO – PubChem

 

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This invention relates to a method of applying a cationic derivative of Minoxidil which is transported by means of iontophoresis to hair follicles where the cationic derivatives promote hair growth. Each of the cationic derivatives of Minoxidil are synthesized by reacting the Minoxidil parent compound with an organic or an inorganic acid to form the cationic derivative.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H1325NO – PubChem

 

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Zebrafish embryos have been shown to be a useful model for the detection of direct acting teratogens. This communication presents a protocol for a 3-day in vitro zebrafish embryo teratogenicity assay and describes results obtained for 10 proteratogens: 2-acetylaminofluorene, benzo[a]pyrene, aflatoxin B1, carbamazepine, phenytoin, trimethadione, cyclophosphamide, ifosfamide, tegafur and thio-TEPA. The selection of the test substances accounts for differences in structure, origin, metabolism and water solubility. Apart from 2-acetylaminofluorene, which mainly produces lethal effects, all proteratogens tested were teratogenic in zebrafish embryos exposed for 3 days. The test substances and/or the substance class produced characteristic patterns of fingerprint endpoints. Several substances produced effects that could be identified already at 1 dpf (days post fertilization), whereas the effects of others could only be identified unambiguously after hatching at ?3 dpf. The LC50 and EC50 values were used to calculate the teratogenicity index (TI) for the different substances, and the EC20 values were related to human plasma concentrations. Results lead to the conclusion that zebrafish embryos are able to activate proteratogenic substances without addition of an exogenous metabolic activation system. Moreover, the teratogenic effects were observed at concentrations relevant to human exposure data. Along with other findings, our results indicate that zebrafish embryos are a useful alternative method for traditional teratogenicity testing with mammalian species.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H1388NO – PubChem

 

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Despite the potential benefits of photopolymerization-based additive manufacturing, photochemical reactions in free-radical polymerization rarely proceed to completion, leading to the accumulation of residual monomer in polymer networks. In this novel study, we examined an array of methacrylate polymers for denture bases (>60 % Bis-EMA and 15?25 % proprietary methacrylic oligomer), orthodontic appliances (>70 % proprietary methacrylic oligomer, <20 % glycol methacrylate and <5 % pentamethyl-piperidyl sebucate) and implant surgical guides (?75 % Bis-EMA and 30?50 % diurethane dimethacrylate, mixture of isomers) using headspace gas chromatography-mass spectrometry. Experimental data reported herein show that a substantial proportion of chemical compounds observed in the methacrylates decreased with post-illumination and the applied ethanol treatment. In the absence of residual methyl methacrylate, other potentially toxic acrylic esters were observed thus emphasizing the need to thoroughly scrutinize additively manufactured dental devices prior to their use. In the long term, standards for medical devices in dentistry could be revised to reflect the current trends in biomaterials and precursors they are generated from. I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 695-53-4, help many people in the next few years.Recommanded Product: 695-53-4

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H1334NO – PubChem

 

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The fetotoxic potential of dimethadione was studied in rats given single daily oral dosages of 0, 54, 216, 433 or 541 mg/kg on days 1-21 or 6-15 of gestation. No maternal toxicity was observed following treatment on days 6-15. When administered from days 1 to 21 only the highest dose (541 ng/kg) produced a significant reduction in maternal body weight gain. Dimethadione caused a dose-related decrease in fetal weight and an increased incidence of umbilical hernia, ecchymoses and subcutaneous edema. There were also increased incidents of non-specific skeleton defects which consisted of unilateral or bilateral wavy ribs, additional ribs (14th rib, uni- and bilateral), retarded ossification of calvaria and a wide variety of sternal defects. Specific defects were bent radius and ulna, and bent tibia and fibula which increased with increasing dosages of dimethadione. Fetal mortality and incidence of skeletal anomalies were higher when the treatment was given on days 1-21 of gestation than on days 6-15 of pregnancy.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H1343NO – PubChem

 

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Synthetic Route of 695-53-4, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Patent, and a compound is mentioned, 695-53-4, 5,5-Dimethyloxazolidine-2,4-dione, introducing its new discovery.

To provide thienopyrazole derivatives inhibiting PDE 7 selectively, and therefore, enhance cellular cAMP level. Consequently, the compound is useful for treating various kinds of disease such as allergic diseases, inflammatory diseases or immunologic diseases. The compound is thienopyrazole compound represented by the following formula (I): [wherein, especially, R1 is a cyclohexyl, a cycloheptyl group or a tetrahydropyranyl group; R2 is methyl; R3 is a hydrogen atom; and R4 is a group: -CONR5R6 (in which any one of R5 and R6 is a hydrogen atom)].

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H1320NO – PubChem

 

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The synthesis of 3-(dimethylamino)-2,2-dimethyl(1-15N)-2H-azirine (1*) was accomplished via reaction of 1-chloro-N,N,2-trimethyl-1-propenylamine (9) and sodium (1-15N) azide (Scheme 3).The earlier reported reactions of 1 with saccharin (10, Scheme 4), phthalimide (12, Scheme 5), and 2H-1,3-benzoxazin-2,4(3H)-dione (16, Scheme 6) were repeated with 1*, and the position of the 15N-label in the products was determined by 15N-NMR spectroscopy.Whereas the postulated reaction mechanismus for 10 and 12 were confirmed by those experiments, the mechanism for the reaction of 16 had to be revised.With respect to the position of 15N in the products 17 and 18, a new mechanism is formulated in Scheme 7.Treatment of 5,5-dimethyl-1,3-oxazolidine-2,4-dione (19) with 1* led to 3,4-dihydro-2H-imidazol-2-on 20 in which only N(3) was labelled.The mechanism of a ring expansion and transannular ring contraction as shown in Scheme 8 is in agreement with this finding.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H1338NO – PubChem

 

Discovery of 5,5-Dimethyloxazolidine-2,4-dione

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Synthetic Route of 695-53-4, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 695-53-4, molcular formula is C5H7NO3, introducing its new discovery.

A convenient, high yield one-pot methodology for the synthesis of pharmaceutically interesting 3-unsubstituted-2,4-oxazolidinediones from alpha-hydroxyesters is described. A primary carbamate was generated in situ from the corresponding alpha-hydroxyester and trichloroacetyl isocyanate, then converted to the desired 3-unsubstituted 2,4-oxazolidinedione via intramolecular ring closure. This method is amenable to scale-up and requires no chromatographic purification.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H1371NO – PubChem

 

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695-53-4, Name is 5,5-Dimethyloxazolidine-2,4-dione, belongs to oxazolidine compound, is a common compound. name: 5,5-Dimethyloxazolidine-2,4-dioneIn an article, once mentioned the new application about 695-53-4.

The reaction of 3-amino-2H-azirines 1 and 1,3-oxazolidine-2,4-diones 2 in MeCN at room temperature leads to 3,4-dihydro-3-(2-hydroxyacetyl)-2H-imidazol-2-ones 3 in good yield (Scheme 2, Table 1).A reaction mechanism proceeding via ring enlargement of the bicyclic zwitterion A to give B, followed by transannular ring contraction to C, is proposed for the formation of 3.This mechanism is in accordance with the result of the reaction of 2a and the 15N-labelled 1a*: in the isolated product 3a*, only N(3) is labelled (Scheme 1).The analogous reaction of 1 and 1,3-thiazolidine-2,4-dione (5) is more complex (Schemes 4 and 5, Table 2).Besides the expected 3,4-dihydro-3-(2-mercaptoacetyl)-2H-imidazol-2-ones 7, 5-amino-3,4-dihydro-2H-imidazol-2-ones of type 8 and/or N-(1,4-thiazin-2-ylidene)ureas 9 are formed.In the case of 2-(dimethylamino)-1-azaspiro<2.3>hex-1-ene (1d), the postulated eight-membered intermediate 6d could be isolated.Its structure as well as that of 9f has been determined by X-ray structure analysis.A reaction mechanism for the formation of the 1,4-thiazine derivatives of type 9 is proposed in Scheme 6.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H1337NO – PubChem

 

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A haloalkylsulfonanilide derivative represented by the formula (I): {wherein R1 represents haloalkyl; R2 represents H, alkylcarbonyl, optionally substituted phenylcarbonyl, alkoxycarbonyl, optionally substituted phenoxycarbonyl, optionally substituted phenylsulfonyl, etc.; R3 and R4 each represents H, alkyl, cycloalkyl, halogeno, CN, etc.; R5, R6, R7, and R8 each represents H, halogeno, alkyl, cycloalkyl, optionally substituted phenyl (C1-6 alkyl), an optionally substituted heterocycle, etc.; A and W each represents O or S; and X represents one to four substituents selected among H, halogeno, alkyl, alkenyl, optionally substituted phenyl, optionally substituted phenylalkylaminocarbonyl, OH, CN, etc.} and a salt thereof; and a herbicide containing any of these compounds as an active ingredient. The herbicide is excellent in wide applicability, persistency, and selectivity for crops and effectiveness against weeds. It is excellent especially as a herbicide for rice fields.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H1321NO – PubChem