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This compound(1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone)Computed Properties of C12H16N2O2 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 67914-60-7, is researched, SMILESS is CC(N1CCN(C2=CC=C(O)C=C2)CC1)=O, Molecular C12H16N2O2Journal, Article, Organic Letters called Ortho-Selective Hydrogen Isotope Exchange of Phenols and Benzyl Alcohols by Mesoionic Carbene-Iridium Catalyst, Author is Zhao, Liang-Liang; Wu, Yixin; Huang, Shiqing; Zhang, Zengyu; Liu, Wei; Yan, Xiaoyu, the main research direction is phenol regioselective deuterium exchange; deuterated phenol preparation; benzyl alc regioselective deuterium exchange; deuterium benzyl alc preparation.Computed Properties of C12H16N2O2.

Hydrogen isotope exchange reactions of phenols and benzyl alcs. was achieved by a mesoionic carbene-iridium catalyst with high ortho selectivity and high functional group tolerance. Control experiments indicated that acetate is crucial to realize the ortho selectivity, whereas d. functional theory calculations supported an outer-sphere direction with hydrogen bonding between acetate and the hydroxyl group.

This compound(1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone)Computed Properties of C12H16N2O2 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

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This compound(1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone)Recommanded Product: 67914-60-7 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Chapman, David R.; Bauer, Ludwig; Waller, Donald P.; Zaneveld, Lourens J. D. researched the compound: 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone( cas:67914-60-7 ).Recommanded Product: 67914-60-7.They published the article 《Synthesis of diastereomeric ketoconazole analogs》 about this compound( cas:67914-60-7 ) in Journal of Heterocyclic Chemistry. Keywords: ketoconazole diastereomer; imidazolylmethyldioxolanylmethoxyphenylpiperazine; piperazinophenol imidazolylmethyldioxolanylmethanesulfonate reaction; NMR ketoconazole. We’ll tell you more about this compound (cas:67914-60-7).

Syntheses of trans-isomers of ketoconazole (I) and the corresponding des-acetyl, 1-Me, 1-formyl and 1-methanesulfonyl analogs were investigated. These isomers, along with the corresponding cis-diastereomers were characterized by their carbon-13 NMR spectra.

This compound(1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone)Recommanded Product: 67914-60-7 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

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This compound(1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone)Category: oxazolidine was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone, is researched, Molecular C12H16N2O2, CAS is 67914-60-7, about Tetra-(acetyl piperazine phenoxy) phthalocyaninato zinc complexes and their proteins conjugates: synthesis, characterisation and photodynamic activities, the main research direction is tetra acetyl piperazine phenoxy phthalocyaninato zinc protein conjugate photodynamic.Category: oxazolidine.

Two zinc phthalocyanines, tetra-α-[4-(4-acetyl piperazine) phenoxy] phthalocyaninato zinc (C80H72N16O8Zn) and tetra-β-[4-(4-acetyl piperazine) phenoxy] phthalocyaninato zinc (C80H72N16O8Zn), have been synthesized and characterized with 1H NMR, MS, IR and elemental anal. The electronic absorption spectra of two complexes in common organic solvents (N,N-DMF, THF, n-octanol) were typical for nonaggregated phthalocyanines, showing a Q band at 693∼698 nm for 1 and 681 ∼ 682 nm for 2. This indicates that the Q band of zinc phthalocyanine with the substituted groups located in the α position is largely red shifted than that in the β position. The spectral features of complexes 1 and 2 in aqueous media suggest the α-substituted groups are more effective than β-substituted groups to hinder the aggregation of phthalocyanine mol. The interactions between two complexes with serum albumin and transferrin (BSA, HSA and apoTf) were investigated by absorption and fluorescence spectroscopy. The binding constants were found to be (1 ∼ 20) × 105 mol-1·L. By comparison, β-substituted 2 had stronger combining ability with albumin than that of α-substituted 1. The non-covalent conjugates (1-BSA, 2-BSA, 1-HSA, 1-apoTf and 1-FeTf) with the molar ratio of about 1 : 1 have also been prepared The photodynamic activities of two complexes and their bioconjugates against MCF-7 mammary tumor cells were examined The result shows that the photocytotoxicities of conjugates are higher than that of complexes 1 ∼ 2 and follows the order 1-BSA > 1-FeTf > 1-HSA, 1-apoTf > 2-BSA > 1>2.

This compound(1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone)Category: oxazolidine was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

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This compound(1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone)Category: oxazolidine was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Category: oxazolidine. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone, is researched, Molecular C12H16N2O2, CAS is 67914-60-7, about 18F-Deoxyfluorination of Phenols via Ru π-Complexes. Author is Beyzavi, Hudson; Mandal, Debashis; Strebl, Martin G.; Neumann, Constanze N.; D’Amato, Erica M.; Chen, Junting; Hooker, Jacob M.; Ritter, Tobias.

The deficiency of robust and practical methods for 18F-radiofluorination is a bottleneck for positron emission tomog. (PET) tracer development. Here, we report the first transition-metal-assisted 18F-deoxyfluorination of phenols. The transformation benefits from readily available phenols as starting materials, tolerance of moisture and ambient atm., large substrate scope, and translatability to generate doses appropriate for PET imaging.

This compound(1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone)Category: oxazolidine was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

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This compound(1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone)Application of 67914-60-7 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone(SMILESS: CC(N1CCN(C2=CC=C(O)C=C2)CC1)=O,cas:67914-60-7) is researched.Application In Synthesis of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone. The article 《Bioinspired Selective Synthesis of Heterodimer 8-5′ or 8-O-4′ Neolignan Analogs》 in relation to this compound, is published in Organic Letters. Let’s take a look at the latest research on this compound (cas:67914-60-7).

The bioinspired synthesis of heterodimer neolignan analogs is reported by single-electron oxidation of both alkenyl phenols and phenols individually, followed by a combination of the resultant radicals. This oxidative radical cross-coupling strategy can afford heterodimer 8-5′ or 8-O-4′ neolignan analogs selectively with the use of air as the terminal oxidant and copper acetate as the catalyst at room temperature

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This compound(1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone)Application In Synthesis of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Application In Synthesis of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone, is researched, Molecular C12H16N2O2, CAS is 67914-60-7, about Synthesis of ketoconazole derivatives. Author is Li, Lu; Tong, Zengshou; Gan, Guizhi.

Title compounds I [R = Ac, P(O)(OEt)2, P(O)(OCHMe2)2] were prepared E.g., reaction of I (R = H) with di-Et phosphite, Et3N, and CCl4 in N,N-dimethylacetamide, CH2Cl2, and benzene gave 86% I [R = P(O)(OEt)2].

This compound(1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone)Application In Synthesis of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

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This compound(1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone)Application In Synthesis of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone(SMILESS: CC(N1CCN(C2=CC=C(O)C=C2)CC1)=O,cas:67914-60-7) is researched.Quality Control of Oxazole. The article 《Structure-Guided Design of a Series of MCL-1 Inhibitors with High Affinity and Selectivity》 in relation to this compound, is published in Journal of Medicinal Chemistry. Let’s take a look at the latest research on this compound (cas:67914-60-7).

Myeloid cell leukemia 1 (MCL-1) is a BCL-2 family protein that has been implicated in the progression and survival of multiple tumor types. Herein the authors report a series of MCL-1 inhibitors that emanated from a high throughput screening (HTS) hit and progressed via iterative cycles of structure-guided design. Advanced compounds from this series exhibited subnanomolar affinity for MCL-1 and excellent selectivity over other BCL-2 family proteins as well as multiple kinases and GPCRs. In a MCL-1 dependent human tumor cell line, administration of compound I rapidly induced caspase activation with associated loss in cell viability. The small mols. described herein thus comprise effective tools for studying MCL-1 biol.

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This compound(1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone)Computed Properties of C12H16N2O2 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Synthesis of axially disubstituted silicon(IV) phthalocyanines and investigation of their photophysical and photochemical properties, published in 2022-02-05, which mentions a compound: 67914-60-7, Name is 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone, Molecular C12H16N2O2, Computed Properties of C12H16N2O2.

In this study, the axially 1-(4-(3-(6-hydroxyhexyl)-3,4-dihydro-2H-benzo[e][1,3]oxazin-6-yl)piperazin-1-yl)ethanone and 1-(4-(3-(2-(2-hydroxyethoxy)ethyl)-3,4-dihydro-2H-benzo[e][1,3]oxazin-6-yl)piperazin-1-yl)ethanone disubstituted silicon(IV) phthalocyanines and their corresponding quaternized derivatives were synthesized for the first time as candidate photosensitizers for photodynamic therapy (PDT) in cancer treatment. The structures of these novel compounds were confirmed by some spectroscopic techniques such as FT-IR, 1H NMR, 13C NMR, UV-Vis, and mass. The axially substitution increased the solubility of the silicon(IV) phthalocyanines. The prepared silicon(IV) phthalocyanines showed great results achieved from photochem. and photophys. investigations in DMSO solution Especially, high singlet oxygen and the fluorescence quantum yield values of the quaternized silicon (IV) phthalocyanines indicates that these compounds have major potential as photosensitizers in PDT. Furthermore, studied silicon(IV) phthalocyanine complexes could be classified as the stable photosensitizer in accordance with photodegradation study results. The fluorescence quenching behavior of these phthalocyanine complexes was also examined using fluorescence quenching method by 1,4-benzoquinone (BQ).

This compound(1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone)Computed Properties of C12H16N2O2 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

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This compound(1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone)Computed Properties of C12H16N2O2 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Jiang, Jie; Seel, Catharina Julia; Temirak, Ahmed; Namasivayam, Vigneshwaran; Arridu, Antonella; Schabikowski, Jakub; Baqi, Younis; Hinz, Sonja; Hockemeyer, Joerg; Mueller, Christa E. published the article 《A2B Adenosine Receptor Antagonists with Picomolar Potency》. Keywords: A2B adenosine receptor antagonist benzenesulfonamide.They researched the compound: 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone( cas:67914-60-7 ).Computed Properties of C12H16N2O2. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:67914-60-7) here.

The A2B adenosine receptor (A2BAR) was proposed as a novel target for the (immuno)therapy of cancer since A2BAR blockade results in antiproliferative, anti-angiogenic, anti-metastatic, and immuno-stimulatory effects. In this study, we explored the structure-activity relationships of xanthin-8-yl-benzenesulfonamides mainly by introducing a variety of linkers and substituents attached to the sulfonamide residue. A new, convergent strategy was established which facilitated the synthesis of the target compounds Many of the new compounds exhibited subnanomolar affinity for the A2BAR combined with high selectivity. Functional groups were introduced which will allow the attachment of dyes and other reporter groups. 8-(4-((4-(4-Bromophenyl)piperazin-1-yl)sulfonyl)phenyl)-1-propylxanthine (34, PSB-1901) was the most potent A2B-antagonist (Ki 0.0835 nM, KB 0.0598 nM, human A2BAR) with >10,000-fold selectivity vs. all other AR subtypes. It was similarly potent and selective at the mouse A2BAR, making it a promising tool for preclin. studies. Computational studies predicted halogen bonding to contribute to the outstanding potency of 34.

This compound(1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone)Computed Properties of C12H16N2O2 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

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《Substituted phthalocyanines and their electropolymerization properties》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone)Formula: C12H16N2O2.

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Substituted phthalocyanines and their electropolymerization properties, published in 2016-10-31, which mentions a compound: 67914-60-7, Name is 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone, Molecular C12H16N2O2, Formula: C12H16N2O2.

New metal-free and metallo-phthalocyanine complexes (Co, TiO) were synthesized using a piperazine-substituted phthalonitrile derivative All proposed structures were supported by instrumental methods. Electrochem. studies of H2-Pc, TiIVOPc, and CoIIPc were examined using cyclic voltammetry (CV) and square-wave voltammetry (SWV) techniques. Voltammetric analyses of phthalocyanines supported the proposed structure of the synthesized complexes. All studied phthalocyanines were oxidatively electropolymerized on the working electrode during the repetitive anodic potential scans.

《Substituted phthalocyanines and their electropolymerization properties》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone)Formula: C12H16N2O2.

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