Category: 5451-40-1

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 5451-40-1, is researched, Molecular C5H2Cl2N4, about Design, synthesis, HER2 inhibition and anticancer evaluation of new substituted 1,5-dihydro-4,1-benzoxazepines, the main research direction is benzenesulfonyl fused azolylbenzoxazepine preparation; HER2 inhibition antitumor SAR pyroptosis induction docking; Antitumour; HER2 receptor; benzoxazepines; molecular modelling; pyroptosis.Safety of 2,6-Dichloropurine.

A series of 11 new substituted 1,5-dihydro-4,1-benzoxazepine derivatives I [X = Y = Z = CH, N; R = H, Cl, Me2N, etc.; R1 = H, Cl; R2 = 4-Me, 4-O2N, 4-O2N] were synthesized to study the influence of the Me group in the 1-(benzenesulfonyl) moiety, the replacement of the purine by the benzotriazole bioisosteric analog, and the introduction of a bulky substituent at position 6 of the purine, on the biol. effects. Their inhibition against isolated HER2 was studied and the structure-activity relationships were confirmed by mol. modeling studies. The most potent compound against isolated HER2 was I [X = Y = N, Z = CH, R = C6H5S, R1 = Cl, R2 = 4-O2N] with an IC50 of 7.31μM. The effects of the target compounds on cell proliferation was investigated. The most active compound was I [X = Y = N, Z = CH, R = R1 = Cl, R2 = 4-Me] against all the tumor cell lines studied (IC50 0.42-0.86μM) does not produce any modification in the expression of pro-caspase 3, but increased the caspase 1 expression and promoted pyroptosis.

《Design, synthesis, HER2 inhibition and anticancer evaluation of new substituted 1,5-dihydro-4,1-benzoxazepines》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(2,6-Dichloropurine)Safety of 2,6-Dichloropurine.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Shi, Lei; Liu, Yan-Hong; Li, Kun; Sharma, Amit; Yu, Kang-Kang; Ji, Myung Sun; Li, Ling-Ling; Zhou, Qian; Zhang, Hong; Kim, Jong Seung; Yu, Xiao-Qi published an article about the compound: 2,6-Dichloropurine( cas:5451-40-1,SMILESS:C2=NC1=C(C(=NC(=N1)Cl)Cl)[NH]2 ).COA of Formula: C5H2Cl2N4. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:5451-40-1) through the article.

The abnormality of the plasma membrane (PM) is an important biomarker for cell status and many diseases. Hence, visualizing the PM, especially in complex systems, is an emerging field in the life sciences, especially in low-resource settings. Herein, we developed a water-soluble PM-specific probe utilizing electrostatic and hydrophobic interaction strategies with aggregation-induced emission as the signal output. The probe could image the PM with many advanced features (wash-free, ultrafast staining process, excellent PM specificity, and good biocompatibility), which were demonstrated by the PM imaging of neurons. The probe allowed for the first time the imaging of erythrocytes in the complex brain environment through a fluorescence-based method. Moreover, the PM of the epidermal and partial view of the eyeball structure of live zebrafish are also revealed.

《An AIE-Based Probe for Rapid and Ultrasensitive Imaging of Plasma Membranes in Biosystems》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(2,6-Dichloropurine)COA of Formula: C5H2Cl2N4.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, International Journal of Molecular Sciences called Synthesis, In Vitro and In Silico Anticancer Activity of New 4-Methylbenzamide Derivatives Containing 2,6-Substituted Purines as Potential Protein Kinases Inhibitors, Author is Kalinichenko, Elena; Faryna, Aliaksandr; Bozhok, Tatyana; Panibrat, Alesya, which mentions a compound: 5451-40-1, SMILESS is C2=NC1=C(C(=NC(=N1)Cl)Cl)[NH]2, Molecular C5H2Cl2N4, Application In Synthesis of 2,6-Dichloropurine.

A novel class of potential protein kinase inhibitors 7-16 was synthesized in high yields using various substituted purines. The most promising compounds, 7 and 10, exhibited inhibitory activity against seven cancer cell lines. The IC50 values for compounds 7 and 10 were 2.27 and 2.53 μM for K562 cells, 1.42 and 1.52 μM for HL-60 cells, and 4.56 and 24.77 μM for OKP-GS cells, resp. In addition, compounds 7 and 10 dose-dependently induced the apoptosis and cell cycle arrest at G2/M phase, preventing the cell division of OKP-GS cells. Compounds 7, 9, and 10 showed 36-45% inhibitory activity against PDGFRα and PDGFRβ at the concentration of 1 μM. Mol. modeling experiments showed that obtained compounds could bind to PDGFRα as either type 1 (compound 7, ATP-competitive) or type 2 (compound 10, allosteric) inhibitors, depending on the substituent in the amide part of the mol.

《Synthesis, In Vitro and In Silico Anticancer Activity of New 4-Methylbenzamide Derivatives Containing 2,6-Substituted Purines as Potential Protein Kinases Inhibitors》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(2,6-Dichloropurine)Application In Synthesis of 2,6-Dichloropurine.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 2,6-Dichloropurine(SMILESS: C2=NC1=C(C(=NC(=N1)Cl)Cl)[NH]2,cas:5451-40-1) is researched.Related Products of 1194-22-5. The article 《System-oriented optimization of multi-target 2,6-diaminopurine derivatives: Easily accessible broad-spectrum antivirals active against flaviviruses, influenza virus and SARS-CoV-2》 in relation to this compound, is published in European Journal of Medicinal Chemistry. Let’s take a look at the latest research on this compound (cas:5451-40-1).

The worldwide circulation of different viruses coupled with the increased frequency and diversity of new outbreaks, strongly highlight the need for new antiviral drugs to quickly react against potential pandemic pathogens. Broad-spectrum antiviral agents (BSAAs) represent the ideal option for a prompt response against multiple viruses, new and re-emerging. Starting from previously identified anti-flavivirus hits, we report herein the identification of promising BSAAs by submitting the multi-target 2,6-diaminopurine chemotype to a system-oriented optimization based on phenotypic screening on cell cultures infected with different viruses. Among the synthesized compounds, 6i showed low micromolar potency against Dengue, Zika, West Nile and Influenza A viruses (IC50 = 0.5-5.3μM) with high selectivity index. Interestingly, 6i also inhibited SARS-CoV-2 replication in different cell lines, with higher potency on Calu-3 cells that better mimic the SARS-CoV-2 infection in vivo (IC50 = 0.5μM, SI = 240). The multi-target effect of 6i on flavivirus replication was also analyzed in whole cell studies (in vitro selection and immunofluorescence) and against isolated host/viral targets.

Different reactions of this compound(2,6-Dichloropurine)Reference of 2,6-Dichloropurine require different conditions, so the reaction conditions are very important.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Electric Literature of C5H2Cl2N4. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 2,6-Dichloropurine, is researched, Molecular C5H2Cl2N4, CAS is 5451-40-1, about Fluorescence Polarization-Based Rapid Detection System for Salivary Biomarkers Using Modified DNA Aptamers Containing Base-Appended Bases. Author is Minagawa, Hirotaka; Shimizu, Akihisa; Kataoka, Yuka; Kuwahara, Masayasu; Kato, Shintaro; Horii, Katsunori; Shiratori, Ikuo; Waga, Iwao.

The field of care testing toward the anal. of blood and saliva lacks nowadays simple test techniques for biomarkers. In this study, the authors have developed a novel nucleobase analog, Ugu, which is a uracil derivative bearing a guanine base at the 5-position. Moreover, the authors attempted the development of aptamers that can bind to secretory IgA (SIgA), which has been examined as a stress marker in human saliva. It was observed that the acquired aptamer binds strongly and selectively to the SIgA dimer (Kd = 13.6 nM) without binding to the IgG and IgA monomers of human serum. Reduction of the aptamer length (41 mer) successfully improved 4-fold the binding affinity (Kd = 3.7 nM), compared to the original, longer aptamer (78 mer). Furthermore, the development of a simple detection system for human saliva samples by fluorescence polarization was investigated, using the reported human salivary α-amylase (sAA) and the SIgA-binding aptamer. Comparison of the present method with conventional ELISA techniques highlighted a significant Pearson’s correlation of 0.94 and 0.83 when targeting sAA and SIgA, resp. It is thus strongly suggested that a new simple test of stress markers in human saliva can be quantified quickly without bound/free (B/F) separation

The article 《Fluorescence Polarization-Based Rapid Detection System for Salivary Biomarkers Using Modified DNA Aptamers Containing Base-Appended Bases》 also mentions many details about this compound(5451-40-1)Electric Literature of C5H2Cl2N4, you can pay attention to it, because details determine success or failure

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Computed Properties of C5H2Cl2N4. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 2,6-Dichloropurine, is researched, Molecular C5H2Cl2N4, CAS is 5451-40-1, about Nucleobase derivatives induce in-source decay of oligonucleotides as new matrix-assisted laser desorption/ionization matrices.

Rationale : For quality control of oligonucleotide therapeutics, accurate and efficient structural characterization using mass spectrometry techniques, such as liquid chromatog./mass spectrometry (LC/MS) and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS), is essential. In MALDI MS anal., matrix selection is critical and a new matrix could enable more efficient and rapid structural anal. Methods : We hypothesized that nucleobase derivatives could act as matrixes more efficiently than the currently used matrixes for oligonucleotides because of structural similarity, which leads to close contact with the analyte. To evaluate their suitability as matrixes, 16 nucleobase derivatives were selected and tested as matrix candidates for oligonucleotide anal. Results : Six of the 16 nucleobase derivatives acted as matrixes for oligonucleotides. Particularly, 6-thioguanine (TG) performed well and induced clear in-source decay fragmentation. When TG or 2-amino-6-chloropurine was used as the matrix, oligonucleotides were ionized, and mainly the w and d fragment ions were observed Conclusions : Herein we demonstrate that a 10-mer RNA or DNA sequence can be successfully characterized using TG as matrix and suggest the possibility of using nucleobase derivatives as novel matrixes in oligonucleotide sequencing.

The article 《Nucleobase derivatives induce in-source decay of oligonucleotides as new matrix-assisted laser desorption/ionization matrices》 also mentions many details about this compound(5451-40-1)Computed Properties of C5H2Cl2N4, you can pay attention to it, because details determine success or failure

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

SDS of cas: 5451-40-1. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 2,6-Dichloropurine, is researched, Molecular C5H2Cl2N4, CAS is 5451-40-1, about Three-in-one: information encryption, anti-counterfeiting and LD-tracking of multifunctional purine derivatives. Author is Wang, Hao-Yuan; Yu, Kang-Kang; Tan, Chong-Yun; Li, Kun; Liu, Yan-Hong; Shi, Lei; Lu, Kai; Yu, Xiao-Qi.

It is still a challenge to develop new intelligent multifunctional fluorescence reagents with high brightness, high optical stability, and high contrast fluorescence based on small mols. In this study, by building push-pull electronic structures and adjusting the number of carbazole groups and the length of the alkyl chain, a series of multifunctional mols. based on a purine-core has been successfully synthesized and achieved the improvement of the fluorescence quantum yield. Furthermore, the relationship between the structure and optical properties of these purine derivatives has been investigated from multiple perspectives. Moreover, the most promising mol. (CPPC) exhibits high fluorescence quantum yield, high brightness, high optical stability, and high contrast fluorescence, and it has been successfully applied in information encryption, anti-counterfeiting and LD-tracking of living cells. The present study offers a novel and efficient approach to develop multifunctional fluorescence materials with high performance based on purine.

The article 《Three-in-one: information encryption, anti-counterfeiting and LD-tracking of multifunctional purine derivatives》 also mentions many details about this compound(5451-40-1)SDS of cas: 5451-40-1, you can pay attention to it, because details determine success or failure

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Hubbard, Troy D.; Liu, Qing; Murray, Iain A.; Dong, Fangcong; Miller, Charles; Smith, Philip B.; Gowda, Krishne; Lin, Jyh Ming; Amin, Shantu; Patterson, Andrew D.; Perdew, Gary H. published an article about the compound: 2,6-Dichloropurine( cas:5451-40-1,SMILESS:C2=NC1=C(C(=NC(=N1)Cl)Cl)[NH]2 ).Recommanded Product: 2,6-Dichloropurine. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:5451-40-1) through the article.

The aryl hydrocarbon receptor (AHR) is a major regulator of immune function within the gastrointestinal tract. Resident microbiota are capable of influencing AHR-dependent signaling pathways via production of an array of bioactive mols. that act as AHR agonists, such as indole or indole-3-aldehyde. Bacteria produce a number of quinoline derivatives, of which some function as quorum-sensing mols. Thus, we screened relevant hydroxyquinoline derivatives for AHR activity using AHR responsive reporter cell lines. 2,8-Dihydroxyquinoline (2,8-DHQ) was identified as a species-specific AHR agonist that exhibits full AHR agonist activity in human cell lines, but only induces modest AHR activity in mouse cells. Addnl. dihydroxylated quinolines tested failed to activate the human AHR. Nanomolar concentrations of 2,8-DHQ significantly induced CYP1A1 expression and, upon cotreatment with cytokines, synergistically induced IL6 expression. Ligand binding competition studies subsequently confirmed 2,8-DHQ to be a human AHR ligand. Several dihydroxyquinolines were detected in human fecal samples, with concentrations of 2,8-DHQ ranging between 0 and 3.4 pmol/mg feces. Addnl., in mice the microbiota was necessary for the presence of DHQ in cecal contents. These results suggest that microbiota-derived 2,8-DHQ would contribute to AHR activation in the human gut, and thus participate in the protective and homeostatic effects observed with gastrointestinal AHR activation.

Different reactions of this compound(2,6-Dichloropurine)Recommanded Product: 2,6-Dichloropurine require different conditions, so the reaction conditions are very important.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Recommanded Product: 5451-40-1. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 2,6-Dichloropurine, is researched, Molecular C5H2Cl2N4, CAS is 5451-40-1, about The Direct Decarboxylative N-Alkylation of Azoles, Sulfonamides, Ureas, and Carbamates with Carboxylic Acids via Photoredox Catalysis.

A method for direct decarboxylative C-N coupling of carboxylic acids RC(O)OH (R = naphthalen-1-yl, 2-phenylpropan-2-yl, 1,2,3,4-tetrahydronaphthalen-1-yl, etc.) with a range of nitrogen nucleophiles, e.g., 5-(4-bromophenyl)-2H-1,2,3,4-tetrazol-2-yl has been described. This platform employs visible-light-mediated photoredox catalysis and an iodine(III) reagent to generate carbocation intermediates directly from aliphatic carboxylic acids via a radical-polar crossover mechanism. A variety of C-N bond-containing products, e.g., I are constructed from a diverse array of nitrogen heterocycles, including pyrazoles, imidazoles, indazoles, and purine bases. Furthermore, sulfonamides, ureas, and carbamates can also be utilized as a nucleophile to generate a selection of N-alkylated products. Notably, a two-step approach to construct free amines directly from the carboxylic acids is accomplished using Cbz-protected amine as a nucleophile.

Different reactions of this compound(2,6-Dichloropurine)Recommanded Product: 5451-40-1 require different conditions, so the reaction conditions are very important.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Safety of 2,6-Dichloropurine. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 2,6-Dichloropurine, is researched, Molecular C5H2Cl2N4, CAS is 5451-40-1, about Synthesis and anticancer activity of N-9- and N-7- substituted 1,2,3 triazole analogues of 2,6-di-substituted purine.

A library of N-9- and N-7-substituted 1,2,3 triazole analogs I [R1 = 2-hydroxyethylamino, benzylamino; R2 = pyrrolidin-1-yl, 1-piperidyl; R3 = H, 4-F, 2-Cl, etc.] and II [R4 = benzylamino; R5 = pyrrolidin-1-yl, 1-piperidyl; R6 = 4-MeO, 4-Br, 4-I] were generated on the 2,6-di-substituted purine upon reaction with various substituted aromatic azides. The synthesized analogs I and II were screened for in-vitro cytotoxic activity against various human cancer cell lines like (HCT-1 (colon), THP-1 (leukemia), IMR-32 (neuroblastoma) and A-549 (lung)). From the bioassay results, it was observed that even though most of the synthesized derivatives I and II exhibited a good potency against various screened cancer cell lines, but few of the analogs like I [R1 = benzylamino; R2 = pyrrolidin-1-yl, 1-piperidyl; R3 = H] and compound I [R1 = benzylamino; R2 = pyrrolidin-1-yl, R3 = 4-Cl] were found to be the most potent analogs in the series, with compound I [R1 = benzylamino, R2 = pyrrolidin-1-yl, R3 = H] showing IC50 values of 0.08 and 0.4 μM against THP-1 and A-549 cell lines, resp.

The article 《Synthesis and anticancer activity of N-9- and N-7- substituted 1,2,3 triazole analogues of 2,6-di-substituted purine》 also mentions many details about this compound(5451-40-1)Safety of 2,6-Dichloropurine, you can pay attention to it, because details determine success or failure

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem