Category: 452339-73-0

452339-73-0, (R)-5-(2,2-Dimethyl-4H-benzo[d][1,3]dioxin-6-yl)oxazolidin-2-one is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of (5R)-5-(2, 2-dimethyl-4H-1, 3-benzodioxin-6-yl)-1, 3-oxazolidin-2-one (4 G) in DMF (25 ml) was added to a suspension of sodium hydride (60% oil dispersion, 1.32 g) in DMF (10 ml) at 0 C and the mixture was stirred for 10 min. A solution of 6-bromohexyl but-3-ynyl ether (5 g) in DMF (15 ml) was added and the cooling bath was removed. The mixture was stirred for 18 h and then concentrated under reduced pressure. The residue was purified by column chromatography on flash silica gel eluting with heptane-ether (2: 1) and then with neat ether to give the title compound (5.8 g). LCMS RT = 3.26 min.

452339-73-0, The synthetic route of 452339-73-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GLAXO GROUP LIMITED; WO2004/39762; (2004); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

452339-73-0,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.452339-73-0,(R)-5-(2,2-Dimethyl-4H-benzo[d][1,3]dioxin-6-yl)oxazolidin-2-one,as a common compound, the synthetic route is as follows.

A solution of (5R)-5-(2, 2-DIMETHYL4H-1, 3-BENZODIOXIN-6-YL)-1, 3-OXAZOLIDIN-2-ONE (2.73g) (WO 02/066422) in DMF (25ML) under nitrogen was treated with sodium hydride (60% dispersion in mineral oil, 526mg) and the mixture stirred at 20 for 15MIN. A solution of {4- [(6-BROMOHEXYL) oxy] -1, 1-dimethylbutyl} benzene (4.117g) in DMF (5ml) was added and the mixture was stirred at 20 for 3h. Phosphate buffer solution (pH 6.5, 25ml) and water (50ML) were added and the mixture was extracted with EtOAc. The extract was washed with water and dried (NA2SO4). The solvent was evaporated in vacuo and the residue purified by flash chromatography on silica gel. Elution with EtOAc-cyclohexane (2: 3) gave the title compound (5. 234G). LCMS RT = 4. 10MIN.

The synthetic route of 452339-73-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GLAXO GROUP LIMITED; WO2004/37768; (2004); A2;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

452339-73-0,452339-73-0, (R)-5-(2,2-Dimethyl-4H-benzo[d][1,3]dioxin-6-yl)oxazolidin-2-one is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of (5R)-5- (2, 2-DIMETHYL-4H-1, 3-BENZODIOXIN-6-YL)-1, 3-OXAZOLIDIN-2-ONE (WO 0266422) (2. 00g) in DMF (25ML) under nitrogen was added sodium hydride (60% dispersion in mineral oil, 0. 38g) and the mixture was stirred at room temperature for 15 min. A solution of 4-[(6-BROMOHEXYL) OXY]-1-BUTENE (2. 07G) in DMF (5ml) was added dropwise and the mixture stirred for 3h. The reaction was quenched with water and partitioned between water and EtOAc. The organic phase was washed with brine, dried (MGS04), and evaporated to dryness. The residual oil was purified on a silica SPE bond elut cartridge (50G) using a gradient of 10%-30% EtOAc in cyclohexane (GRADMASTETM). The appropriate fractions were evaporated to give the title compound (2.66g) LCMS RT = 3.47 min.

452339-73-0 (R)-5-(2,2-Dimethyl-4H-benzo[d][1,3]dioxin-6-yl)oxazolidin-2-one 10933894, aoxazolidine compound, is more and more widely used in various fields.

Reference£º
Patent; GLAXO WELLCOME HOUSE; WO2004/37773; (2004); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

452339-73-0,452339-73-0, (R)-5-(2,2-Dimethyl-4H-benzo[d][1,3]dioxin-6-yl)oxazolidin-2-one is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In a 50 mL three-necked flask, Replace the nitrogen three times, 0 C, To a solution of compound 1-16 (110 mg, 0,4 mmol) in N, N-dimethylformamide (5 mL) was added potassium tert-butoxide (50 mg, 0.44 mmol) Stirring for 1 hour, Compound 1-6 (20011 ^, 0.6611111101) was added, The reaction was allowed to proceed at room temperature for 5 hours. Ethyl acetate (501 ^), Followed by extraction with water (501 ^) and saturated brine (50 mL). Organic phase dry, filter, concentrate. Silica gel plate (ethyl acetate / petroleum ether = 1/2) to give 100 mg of product as a pale yellow oil.

As the paragraph descriping shows that 452339-73-0 is playing an increasingly important role.

Reference£º
Patent; Yifang Bio-technology (Shanghai) Co., Ltd.; Dai Xing; Jiang Yueheng; Wang Yaolin; (21 pag.)CN107188813; (2017); A;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

452339-73-0, (R)-5-(2,2-Dimethyl-4H-benzo[d][1,3]dioxin-6-yl)oxazolidin-2-one is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,452339-73-0

Sodium hydride (60% dispersion in oil 1.26 g) was added to a stirred, cooled (ice-bath) solution of (5R)-5- (2, 2-dimethyl-4H-1, 3-benzodioxin-6-yl)-2-oxazolidinone (5.47 g) in dry DMF (50 ml) under nitrogen and the mixture was stirred for 15 min at 5 C. A solution of 6-bromohexyl 4- (3-IODOPHENYL) BUTYL ether (10.7 g) in DMF (30 ML) was then added dropwise over 10 min. The mixture was stirred for 2 h at ambient temperature, then poured into aqueous solution of ammonium chloride and extracted into ethyl acetate. The combined extracts were washed with water, dried (NA2SO4) and evaporated. The residue was purified on biotage (90 g cartridge) eluting with ether-hexane (3: 2) to give the title compound (9.8 g). LCMS RT= 4.20 min.

The synthetic route of 452339-73-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GLAXO WELLCOME HOUSE; WO2004/37773; (2004); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

452339-73-0, (R)-5-(2,2-Dimethyl-4H-benzo[d][1,3]dioxin-6-yl)oxazolidin-2-one is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Sodium hydride (60% oil dispersion, 1.4g) was added to a stirred solution of (5R)- (2, 2- DIMETHYL-4H-1, 3-BENZODIOXIN-6YL)-1, 3OXAZOLIDIN-2-ONE (6. 0G) in dry dimethylformamide (80ML) at 0 under nitrogen. After 20 min a solution of 1- {4- [ (6-BROMOHEXYL) oxy] butyl}-4- iodobenzene (12.6g) in dry dimethylformamide (30ML) was added dropwise. The mixture was stirred for 15h at ambient temperature. The mixture was poured into an aqueous ammonium chloride solution (700MI) and extracted into ethyl acetate. The organic extracts were washed with water, dried (NA2SO4) and evaporated. Purification by chromatography on a biotage cartridge (90g) using ether-petroleum ether (40-60) (4: 1) gave the title compound as a clear oil (10G). LCMS RT = 4.19 min.

452339-73-0, As the paragraph descriping shows that 452339-73-0 is playing an increasingly important role.

Reference£º
Patent; GLAXO GROUP LIMITED; WO2004/39762; (2004); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

452339-73-0,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.452339-73-0,(R)-5-(2,2-Dimethyl-4H-benzo[d][1,3]dioxin-6-yl)oxazolidin-2-one,as a common compound, the synthetic route is as follows.

In a 50 mL three-necked flask, Replace the nitrogen three times, 0 C, To a solution of compound l-16 (70 mg, 0.28 mmol) Of N, N-dimethylformamide (1 OmL) (3lmg, 0.28mmo 1) was added to the solution, and after the reaction was carried out at room temperature for 0.5 h, Compound 4_4 (100 mg, 0.31 mmol) was added to the reaction system, Continue to react for 3 h. Ethyl acetate (50 mL) was added, Followed by extraction with water (50 mL) and saturated brine (50 mL). Organic phase dry, filter, concentrate. Silica gel plate (ethyl acetate / petroleum ether = 1/4) was purified to give 13 mg of product as a pale yellow oil.

452339-73-0 (R)-5-(2,2-Dimethyl-4H-benzo[d][1,3]dioxin-6-yl)oxazolidin-2-one 10933894, aoxazolidine compound, is more and more widely used in various fields.

Reference£º
Patent; Yifang Bio-technology (Shanghai) Co., Ltd.; Dai Xing; Jiang Yueheng; Wang Yaolin; (21 pag.)CN107188813; (2017); A;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

452339-73-0, (R)-5-(2,2-Dimethyl-4H-benzo[d][1,3]dioxin-6-yl)oxazolidin-2-one is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of (5R)-5-(2, 2-dimethyl-4H-1, 3-benzodioxin-6-yl)-1, 3-oxazolidin-2-one (Example 1 viii) (503mg) in DMF (10mL) was treated with sodium hydride (60% dispersion in mineral oil) (97mg) under nitrogen for 20 min. A solution of 1-[2-(benzyloxy) ethoxy] -4- (2-bromoethyl) benzene (676mg) in DMF (5 mL) was added and the reaction stirred for a further 2 h. The reaction mixture was concentrated in vacuo then the residue was prified by chromatography (Biotage, 40g) eluting with EtOAc-petroleum ether (2: 3) to give the title compound (585mg). LCMS RT = 3.66 min

452339-73-0, 452339-73-0 (R)-5-(2,2-Dimethyl-4H-benzo[d][1,3]dioxin-6-yl)oxazolidin-2-one 10933894, aoxazolidine compound, is more and more widely used in various fields.

Reference£º
Patent; GLAXO GROUP LIMITED; WO2003/91204; (2003); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.452339-73-0,(R)-5-(2,2-Dimethyl-4H-benzo[d][1,3]dioxin-6-yl)oxazolidin-2-one,as a common compound, the synthetic route is as follows.

(5R)-5-(2, 2-Dimethyl-4H-1, 3-benzodioxin-6-yl)-1, 3-oxazolidin-2-one (651 mg) in DMF (15mL) was treated with sodium hydride (84mg) under nitrogen and stirred for 1 h. A solution of 2- [4- (2-bromoethyl) phenoxy] ethyl acetate (500mg) in DMF (5mL) was added and the reaction mixture was stirred for a further 2 h. This was then concentrated in vacuo and the residue was taken up in EtOAc, washed with water, brine and dried (MgS04). The solution was concentrated in vacuo and the residue was purified by chromatography (Biotage, 90g) eluting with cyclohexane-EtOAc (2: 1) to give the title compound (355mg). LCMS RT=3. 26min.

452339-73-0, As the paragraph descriping shows that 452339-73-0 is playing an increasingly important role.

Reference£º
Patent; GLAXO GROUP LIMITED; WO2003/91204; (2003); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.452339-73-0,(R)-5-(2,2-Dimethyl-4H-benzo[d][1,3]dioxin-6-yl)oxazolidin-2-one,as a common compound, the synthetic route is as follows.

(5R)-5-(2,2-Dimethyl-4H-1,3-benzodioxin-6-yl)-1,3-oxazolidin-2-one (10g) in DMF (100ml) was added dropwise to a stirred suspension of sodium hydride (60% oil dispersion, 2.33g) in DMF (50ml) with stirring under nitrogen and maintaining the internal temperature at 0. Stirring was continued at 0-5 for 1 h. The mixture was recooled to 0 and a solution of 6-bromohexyl but-3-ynyl ether (14.7g) in DMF (50moi) was added over 1 min. The mixture was then stirred at 20-30 for 2 h. 2M HCl (9ml) was added and the mixture was partitioned between water and diethyl ether. The aqueous layer was extracted with more diethyl ether and the combined organic layers were washed twice with brine. After drying (MgSO4) the solution was concentrated and loaded onto a column of silica gel (600g) set up in diethyl ether: petroleum ether (bp 40-60) (1 : 2). The column was eluted successively with this mixture, then (1 : 1) and the diethyl ether to give the title compound (13.88g). LCMS RT=3.45min.

452339-73-0, 452339-73-0 (R)-5-(2,2-Dimethyl-4H-benzo[d][1,3]dioxin-6-yl)oxazolidin-2-one 10933894, aoxazolidine compound, is more and more widely used in various fields.

Reference£º
Patent; GLAXO GROUP LIMITED; WO2003/72539; (2003); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem