Category: 39657-45-9

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. COA of Formula: C3H8ClNO. Introducing a new discovery about 39657-45-9, Name is Isoxazolidine hydrochloride

N-ALKOXYAMIDES OF 6-(TRISUBSTITUTED PHENYL)-4-AMINOPICOLINATES AND THEIR USE AS SELECTIVE HERBICIDES FOR CROPS

N-Alkoxyamides of 4-aminopicolinic acids and 6-amino-4-pyrimidinecarboxylates are selective herbicides for corn, canola and sugar beet.

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Reference：
Oxazolidine – Wikipedia,
Oxazolidine | C3H1260NO – PubChem

 

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Preparation and opioid activity of analogues of the analgesic dipeptide 2,6-dimethyl-L-tyrosyl-N-(3-phenylpropyl)-D-alaninamide

A number of analogues of the recently disclosed analgesic dipeptide 2,6- dimethyl-L-tyrosyl-D-alanine-phenylpropylamide (SC-39566, 2) were prepared. These analogues contained oxymethylene, aminomethylene, ketomethylene, bismethylene, and trans double bond (including vinyl fluoride) isosteric replacements for the amide bond between the D-alanine and phenylpropylamine units in 2. These compounds were tested in opioid binding assays and in the mouse writhing assay for analgesic activity. Though not as potent as 2, the oxymethylene, and trans double bond isosteres showed analgesic activity. The aminomethylene analogues also showed binding activity in subnanomolar concentrations at the mu receptor. The amide bond between 2,6-dimethyl-L- tyrosine and D-alanine units seems to be critical for opioid activity.

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Reference：
Oxazolidine – Wikipedia,
Oxazolidine | C3H1281NO – PubChem

 

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IL-8 RECEPTOR ANTAGONISTS

This invention relates to novel compounds of Formula (I), and compositions thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).

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Reference：
Oxazolidine – Wikipedia,
Oxazolidine | C3H1268NO – PubChem

 

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alpha-Amino Acid Derivatives as Chiral Educts for Asymmetric Products. Synthesis of Shpingosine from alpha’-Amino-alpha,beta-ynones

The utility of alpha’-amino-alpha,beta-ynones in the chirospecific synthesis of sphingosine is demonstrated.Thus, a protected L-serine isoxazolidide has been converted to sphingosine by two routes, both via alpha,beta-ynones.The first route is very short and high yielding, merely involving two selective reductions after synthesis the appropriate alpha,beta-ynone.The second route involves alkylation of a beta-unsubstituted ynone and illustrates the synthetic versatility of the alpha’-amino-alpha,beta-ynone system.Further routes through conjugate 1,4-additions to ynones are demonstrated but are limited by the highly reactive nature of this system.

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Reference£º
Oxazolidine – Wikipedia,
Oxazolidine | C3H1277NO – PubChem

 

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Cocaine and 3beta-(4′-substituted phenyl)tropane-2beta-carboxylic acid ester and amide analogues. New high-affinity and selective compounds for the dopamine transporter

Several 2beta-carboxylic acid ester and amide analogues of cocaine and of 3beta-(4′-substituted phenyl)tropane-2beta-carboxylic acid were prepared. The binding affinities of these compounds, and of some previously prepared analogues, at the dopamine (DA), norepinephrine (NE), and serotonin (5-HT) transporters were determined. The phenyl esters of 3beta-(4′-methylphenyl)and 3beta-(4′-chlorophenyl)tropane-2beta-carboxylic acid are highly potent and highly selective for the DA transporter. The isopropyl esters of 3beta-(4′- chlorophenyl)- and 3beta-(4′-iodophenyl)tropane-2beta-carboxylic acid also possess high DA affinity and show significant DA transporter selectivity. Similarly, the phenyl and isopropyl ester analogues of cocaine are much more selective for the DA transporter than cocaine. Tertiary amide analogues of cocaine and of 3beta-(4′-substituted phenyl)tropane-2beta-carboxylic acids are more potent inhibitors of radioligand binding at the DA transporter than the primary and secondary amide analogues. In particular, 3beta-(4′- chlorophenyl)tropane-2beta-N-morpholinocarboxamide as well as the 3beta-(4′- chlorophenyl)- and 3beta-(4′-iodophenyl)tropane-2beta-N-pyrrolidinocarboxamides possess high affinity and selectivity for the DA transporter. The N,N- dimethylamide cocaine analogue is the most selective cocaine amide derivative for the DA transporter. High correlation between the inhibition of radioligand binding and inhibition of uptake at the DA, NE, and 5-HT transporter was found for a selected group of analogues. Within this group, one compound, the isopropyl ester of 3beta-(4′-iodophenyl)-tropane-2beta- carboxylic acid, was found to be more potent in the inhibition of radioligand binding than in the inhibition of DA uptake. Taken together with its high potency and selectivity at the DA transporter, this suggests that this compound may be a lead in the development of a cocaine antagonist.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H1280NO – PubChem

 

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 39657-45-9, name is Isoxazolidine hydrochloride, introducing its new discovery. SDS of cas: 39657-45-9

A 6 – chlorophenyl and oxazole […] amide compound and use thereof (by machine translation)

This invention relates to a 6 – chlorophenyl and oxazole […] amide compounds and their use as herbicides, the compound such as formula (I) as shown: Wherein: C W is selected from1 – 4 Alkylene. The compounds of this invention not only has excellent herbicidal activity, but also safe to the crop. (by machine translation)

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Oxazolidine – Wikipedia,
Oxazolidine | C3H1266NO – PubChem

 

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 39657-45-9, name is Isoxazolidine hydrochloride, introducing its new discovery. Computed Properties of C3H8ClNO

Auristatin derivatives and use thereof

The present application relates to novel derivatives of monomethylauristatin F, to processes for preparing these derivatives, to the use of these derivatives for treating and/or preventing diseases, and also to the use of these derivatives for preparing medicaments for treating and/or preventing diseases, more particularly hyperproliferative and/or angiogenic disorders such as, for example, cancerous disorders. Such treatments may be practised as a monotherapy or else in combination with other medicaments or further therapeutic measures.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H1265NO – PubChem

 

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 39657-45-9, name is Isoxazolidine hydrochloride, introducing its new discovery. category: oxazolidine

A 1, 2 – four hydrogens different wicked zuo hydrochloride preparation method (by machine translation)

The present invention provides a 1, 2 – four hydrogens different wicked zuo hydrochloride preparation method, mainly solves the low yield in the synthesis process, the reaction is not easy to control, the operation of the experiment the technical problem of the inconvenience, the present invention in order to N – tert butoxycarbonyl – hydroxylamine hydrochloride and 1, 3 – dibromo propane is used as the starting material, in order to sodium hydroxide as the alkali, tetrahydrofuran as the solvent, heating to reflux 6 hours so as to prepare N – Boc – four hydrogens different wicked zuo, then removing the Boc protection, get 1, 2 – four hydrogens different wicked zuo hydrochloride. 1. 2 – Four hydrogens different wicked zuo hydrochloride useful intermediates in the synthesis of many drugs. (by machine translation)

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Oxazolidine – Wikipedia,
Oxazolidine | C3H1258NO – PubChem

 

Electric Literature of 39657-45-9, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Patent, and a compound is mentioned, 39657-45-9, Isoxazolidine hydrochloride, introducing its new discovery.

SUBSTITUTED 4-BENZYL AND 4-BENZOYL PIPERIDINE DERIVATIVES

Described herein are 1,4-substituted piperidine compounds according to Formula I that have demonstrated activity as fatty acid synthase inhibitors. Also described herein are pharmaceutical compositions containing the described 1,4-substituted piperidine compounds. Also described herein are methods of treating diseases mediated by fatty acid synthase, by administering one or more of the compounds or pharmaceutical formulations described herein. Also described herein are methods of synthesizing the described 1,4-substituted piperidine compounds and synthetic intermediates useful in those syntheses.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H1256NO – PubChem

 

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 39657-45-9, name is Isoxazolidine hydrochloride, introducing its new discovery. name: Isoxazolidine hydrochloride

2-Substituted Hydroxylaminopyrimidine, Method for the Production and the Use Thereof in the Form of Pesticides

2-Substituted pyrimidines of the formula I, where the indices and substituents are as defined in the description.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H1262NO – PubChem