Category: 34052-90-9

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 34052-90-9, Name is 1,3-Bis(4,5-dihydrooxazol-2-yl)benzene, molecular formula is C12H12N2O2. In an article, author is Barthel, Benjamin L.,once mentioned of 34052-90-9, Recommanded Product: 34052-90-9.

Correlation of in Situ Oxazolidine Formation with Highly Synergistic Cytotoxicity and DNA Cross-Linking in Cancer Cells from Combinations of Doxorubicin and Formaldehyde

Anthracyclines are a class of antitumor compounds that are successful and widely used but suffer from cardiotoxicity and acquired tumor resistance. Formaldehyde interacts with anthracyclines to enhance antitumor efficacy, bypass resistance mechanisms, improve the therapeutic profile, and change the mechanism of action from a topoisomerase II poison to a DNA cross-linker. Contrary to current dogma, we show that both efficient DNA cross-linking and potent synergy in combination with formaldehyde correlate with the anthracycline’s ability to form cyclic formaldehyde conjugates as oxazolidine moieties and that the cyclic conjugates are better cross-linking agents and cytotoxins than acyclic conjugates. We also provide evidence that suggests that the oxazolidine forms in situ, since cotreatment with doxorubicin and formaldehyde is highly cytotoxic to dox-resistant tumor cell lines, and that this benefit is absent in combinations of formaldehyde and, epirubicin, which cannot form stable oxazolidines. These results have potential clinical implications in the active field of anthracydine prodrug design and development.

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Reference:
Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem

 

Chemistry is an experimental science, Category: oxazolidines, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 34052-90-9, Name is 1,3-Bis(4,5-dihydrooxazol-2-yl)benzene, molecular formula is C12H12N2O2, belongs to oxazolidines compound. In a document, author is Sundermann, Tom.

Convergent and enantioselective syntheses of cytosolic phospholipase A(2)alpha inhibiting N-(1-indazol-1-ylpropan-2-yl) carbamates

Cytosolic phospholipase A(2)alpha (cPLA(2)alpha) is an important enzyme of the inflammation cascade. Therefore, inhibitors of cPLA(2)alpha are assumed to be promising drug candidates for the treatment of inflammatory disorders. Recently we have found that indole-5-carboxylic acid with a 3-(4-octylphenoxy)-2-(phenoxycarbonylamino) propyl substituent in position 1 is an inhibitor of cPLA(2)alpha. We have now synthesized a corresponding derivative with the indole heterocycle replaced by an indazole (4) employing an analogous reaction sequence as for the synthesis of the indole derivative. Besides, a more convergent synthesis for 4 was established using an aziridine as central intermediate. Furthermore, a chiral-pool based enantioselective synthesis was developed for the synthesis of (R)- and (S)-4. Starting compound for both enantiomers was the (R)-serine derived oxazolidine (R)-25. Compound 4 proved to be a moderate inhibitor of cPLA(2)alpha, with the S-enantiomer being twice as active as the R-enantiomer. The racemate 4 and the enantiomers (R)-and (S)-4 showed a high in vitro metabolic stability in rat liver S9 fractions.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 34052-90-9, in my other articles. Category: oxazolidines.

Reference:
Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem

 

Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 34052-90-9, Name is 1,3-Bis(4,5-dihydrooxazol-2-yl)benzene, molecular formula is , belongs to oxazolidines compound. In a document, author is Caracelli, Ignez, Quality Control of 1,3-Bis(4,5-dihydrooxazol-2-yl)benzene.

(R)-2-Phenoxy-1-(4-phenyl-2-sulfanylidene-1,3-oxazolidin-3-yl)ethanone

The central 1,3-oxazolidine-2-thione ring in the title compound, C17H15NO3S, is approximately planar with maximum deviations of 0.036 (4) and -0.041 (5) angstrom for the O and methylene-C atoms, respectively. The dihedral angles formed between this plane and the two benzene rings, which lie to the same side of the central plane, are 86.5 (2) [ring-bound benzene] and 50.6 (3)degrees. The ethan-1-one residue is also twisted out of the central plane, forming a O-C-N-C torsion angle of 151.5 (5)degrees. The dihedral angle formed by the benzene rings is 62.8 (2)degrees so that overall, the molecule has a twisted U-shape. In the crystal, molecules are linked into supramolecular arrays two molecules thick in the bc plane through C-H center dot center dot center dot O, C-H center dot center dot center dot S and C-H center dot center dot center dot pi interactions.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 34052-90-9, in my other articles. Quality Control of 1,3-Bis(4,5-dihydrooxazol-2-yl)benzene.

Reference:
Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem

 

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 34052-90-9, Name is 1,3-Bis(4,5-dihydrooxazol-2-yl)benzene, formurla is C12H12N2O2. In a document, author is Kraft, Jochen, introducing its new discovery. Application In Synthesis of 1,3-Bis(4,5-dihydrooxazol-2-yl)benzene.

Spiro-fused carbohydrate oxazoline ligands: Synthesis and application as enantio-discrimination agents in asymmetric allylic alkylation

In the present work, we describe a convenient synthesis of spiro-fused D-fructo-and D-psico-configurated oxazoline ligands and their application in asymmetric catalysis. The ligands were synthesized from readily available 3,4,5-tri-O-benzyl-1,2-O-isopropylidene-beta-D-fructopyranose and 3,4,5-tri-O-benzyl-1,2-O-isopropylidene-beta-D-psicopyranose, respectively. The latter compounds were partially deprotected under acidic conditions followed by condensation with thiocyanic acid to give an anomeric mixture of the corresponding 1,3-oxazolidine-2-thiones. The anomeric 1,3-oxazolidine-2-thiones were separated after successive benzylation, fully characterized and subjected to palladium catalyzed Suzuki-Miyaura coupling with 2-pyridineboronic acid N-phenyldiethanolamine ester to give the corresponding 2-pyridyl spiro-oxazoline (PyOx) ligands. The spiro-oxazoline ligands showed high asymmetric induction (up to 93% ee) when applied as chiral ligands in palladium-catalyzed allylic alkylation of 1,3-diphenylallyl acetate with dimethyl malonate. The D-fructo-PyOx ligand provided mainly the (R)-enantiomer while the D-psico-configurated ligand gave the (S)-enantiomer with a lower enantiomeric excess.

If you are hungry for even more, make sure to check my other article about 34052-90-9, Application In Synthesis of 1,3-Bis(4,5-dihydrooxazol-2-yl)benzene.

Reference:
Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem

 

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 34052-90-9, Name is 1,3-Bis(4,5-dihydrooxazol-2-yl)benzene, formurla is C12H12N2O2. In a document, author is Yuan, Liemei, introducing its new discovery. Computed Properties of C12H12N2O2.

Synthesis of oxazolidines as latent curing agents for single-component polyurethane adhesive and its properties study

Four oxazolidine compounds OX1-OX4 were prepared. Their structures were characterized using Fourier transform infrared spectra, H-1-NMR, C-13-NMR, and ESI-MS. The hydrolysis kinetics research of oxazolidines suggested that the hydrolysis of oxazolidine followed the first-order reaction. The gap of the ground energies between the open- and closed-ring was calculated using Gaussian software, which indicated that the stability of the open-ring system of OX1 was the best. Then, the obtained oxazolidines were applied to single-component polyurethane (SPU) and filler CaCO3 was added to investigate the effect of the two above on the properties of SPU. The results show that the pore size and the number of bubbles produced in the SPU decreased with the increase of the rate of hydrolysis of the added oxazolidine, and the bondability of the polyurethane was better. With the increase of CaCO3 content, the polyurethane surface became smoother and the bond strength was stronger. (c) 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 45722.

If you are hungry for even more, make sure to check my other article about 34052-90-9, Computed Properties of C12H12N2O2.

Reference:
Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem

 

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. Recommanded Product: 34052-90-9, 34052-90-9, Name is 1,3-Bis(4,5-dihydrooxazol-2-yl)benzene, SMILES is C1(C2=NCCO2)=CC=CC(C3=NCCO3)=C1, in an article , author is Zhang, Lanyun, once mentioned of 34052-90-9.

Effect of heat processing on oxazolidine ofCapparis masaikaiLevI.

Capparis masaikai, as a Chinese local plant, its mature seeds are used in traditional Chinese medicine and commonly chewed for their sweet taste. However, the seeds also contain 2-hydroxyethylglucosinolate (2-Hydr GLS), which can be hydrolyzed by the myrosinase enzyme to product bitterness and harmful substance 1,3-oxazolidine-2-thione (OZT). In this study, heat processing has been used to reduce the OZT inC. masaikaiseeds. The effect of heat processing on myrosinase enzymatic activity, 2-Hydr GLS content and water content has been investigated by incubation under different temperatures (30-90 degrees C). Further experiments using mice model showed that feeding of heat processedC. masaikaiseeds eliminated the content of OZT in mice blood. Thus, our study indicated that heat processing could be used as an effective method to reduce the harmful OZT and improve the taste ofC. masaikaiseeds.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 34052-90-9, you can contact me at any time and look forward to more communication. Recommanded Product: 34052-90-9.

Reference:
Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem

 

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 34052-90-9, Name is 1,3-Bis(4,5-dihydrooxazol-2-yl)benzene, formurla is C12H12N2O2. In a document, author is Musci, Pantaleo, introducing its new discovery. COA of Formula: C12H12N2O2.

Stereo- and Enantioselective Addition of Organolithiums to 2-Oxazolinylazetidines as a Synthetic Route to 2-Acylazetidines

A new synthetic route to N-alkyl-2-acylazetidines was developed through a highly stereoselective addition of organolithiums to N-alkyl-2-oxazolinylazetidines followed by acidic hydrolysis of the resulting oxazolidine intermediates. This study revealed an unusual reactivity of the C=N bond of the oxazoline group when reacted with organolithiums in a non-polar solvent such as toluene. The observed reactivity has been explained considering the role of the nitrogen lone pair of the azetidine ring as well as of the oxazolinyl group in promoting a complexation of the organolithium, thus ending up with the addition to the C=N double bond. The high level of stereoselectivity in this addition is supported by DFT calculations and NMR investigations, and a model is proposed for the formation of the oxazolidine intermediates, that have been isolated and fully characterized. Upon acidic conditions, the oxazolidine moieties were readily converted into 2-acylazetidines. This synthetic approach has been applied for the preparation of highly enantioenriched 2-acylazetidines starting from chiral not racemic N-alkyl-2-oxazolinylazetidines.

If you are hungry for even more, make sure to check my other article about 34052-90-9, COA of Formula: C12H12N2O2.

Reference:
Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem

 

Application of 34052-90-9, Redox catalysis has been broadly utilized in electrochemical synthesis due to its kinetic advantages over direct electrolysis. The appropriate choice of redox mediator can avoid electrode passivation and overpotential. 34052-90-9, Name is 1,3-Bis(4,5-dihydrooxazol-2-yl)benzene, SMILES is C1(C2=NCCO2)=CC=CC(C3=NCCO3)=C1, belongs to oxazolidines compound. In a article, author is Guignard, Guillaume, introduce new discover of the category.

A General Method for the Synthesis of Enantiopure 1,5-Amino Alcohols

A variety of (R)-phenylglycinol-derived oxazolopiperidone lactams 1-14 were converted to linear-chain enantiopure amino diols 15-26 by reduction with LiNH2BH3 in an unprecedented process involving the simultaneous reductive opening of the oxazolidine and lactam rings. Subsequent removal of the phenylethanol moiety gave enantiopure 5-amino-1-pentanols bearing substituents at the 2-, 3-, 4-, 2,2-, 2,3- 2,4- and 3,4-positions (28-36), which were isolated as their N-Boc derivatives.

Application of 34052-90-9, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 34052-90-9 is helpful to your research.

Reference:
Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem

 

Application of 34052-90-9, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 34052-90-9, Name is 1,3-Bis(4,5-dihydrooxazol-2-yl)benzene, SMILES is C1(C2=NCCO2)=CC=CC(C3=NCCO3)=C1, belongs to oxazolidines compound. In a article, author is Turkiewicz, Anna, introduce new discover of the category.

Laboratory research on selection of effective antimicrobial substances and H2S scavengers used in drilling fluid technology and underground gas storage

The article discusses the results of biocide tests for application in the oil and gas industry. This research was carried out with the use of active agents, such as: nano-silver particle suspension, and the solutions of two antimicrobial substances. The second part of the laboratory study was testing H2S scavengers. Preparations recommended for drilling fluid technology and underground gas storage facilities were used. It should be noted that biogenic processes can largely cause the phenomenon of degradation of drilling fluids. As a result of these processes, drilling mud gets contaminated and loses its technological and rheological properties, making it incapable of fulfilling its role during drilling operations. All the tested scavengers were triazine products. In general, this agent in a solution acts in two ways. The application of triazine derivatives (three isomeric forms) is a good means of eliminating microorganisms from drilling fluid or formation water. These active agents have strong antimicrobial properties. On the other hand, these substances can also neutralise the hydrogen sulphide. The research enaNafta-Gabled determination of the effectiveness of the antimicrobial activity of the following substances: nano-silver particles, nano-Ag in combination with oxazolidine, and nano-Ag with a combination with glyoxal. The results of laboratory tests also allowed for a comparison of the efficiency of the action of individual H2S scavengers. The first two tests were conducted in the range of nano-silver particles concentrations from 0.05 to 0.6% vol., while the next tests (i.e. with the application of nano-Ag/biocide) were carried out in the concentration range from 0.02 to 0.5% vol. Bacterial or fungal colony units (CFU) were used as a reference method for assessing the microbial water quality. The formation water came from a facility of underground gas storage (collective water – i.e. water from separators). In parallel tests, the number of bacteria was also determined in the contaminated water-based polymer drilling mud. The number of microorganisms in the tested samples was compared with the CFUs in control samples without biocide. The described research is part of a complex study intended to conduct biomonitoring of deposit environments and to eliminate bacterial contamination and sulphating of hydrocarbons, especially in stored natural gas. Industrial operations in this field make it possible to maintain the correct quality of stored gas and contribute to the improvement of exploitation. Selected effective substances will be used in the future in industry to reduce the content of biogenic hydrogen sulphide and to decrease a number of harmful microorganisms in drilling muds and formation waters.

Application of 34052-90-9, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 34052-90-9 is helpful to your research.

Reference:
Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem

 

In an article, author is Aminto, Alison, once mentioned the application of 34052-90-9, Computed Properties of C12H12N2O2, Name is 1,3-Bis(4,5-dihydrooxazol-2-yl)benzene, molecular formula is C12H12N2O2, molecular weight is 216.24, MDL number is MFCD00191606, category is oxazolidines. Now introduce a scientific discovery about this category.

Four-compartment partition model of hazardous components in hydraulic fracturing fluid additives

Mass balance principles were applied to a four-compartment partition model for 12 different hazardous components of hydraulic fracturing fluid additives used in 47 completed natural gas wells in the Marcellus Shale. Spill scenarios were modeled as if 1000 gallons of diluted additive were discharged into a surface water body or onto soil. Resulting concentrations were ranked according to magnitude, providing a relative comparison of quantities to be expected in each compartment. Highest mass concentrations in the water, soil and biota compartments were due to sodium hydroxide, 4,4-dimethyl oxazolidine, and hydrochloric acid. 4,4-dimethyl oxazolidine ranked highest in the air compartment. (C) 2012 Elsevier B.V. All rights reserved.

If you are interested in 34052-90-9, you can contact me at any time and look forward to more communication. Computed Properties of C12H12N2O2.

Reference:
Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem