Category: 34052-90-9

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Computed Properties of C12H12N2O2, 34052-90-9, Name is 1,3-Bis(4,5-dihydrooxazol-2-yl)benzene, SMILES is C1(C2=NCCO2)=CC=CC(C3=NCCO3)=C1, belongs to oxazolidines compound. In a document, author is Hasaniya, Nahidh W., introduce the new discover.

Amelioration of Ischemia-Reperfusion Injury in an Isolated Rabbit Lung Model Using OXANOH

Objective: Acute respiratory distress syndrome (ARDS) remains a major cause of morbidity and mortality. Oxygen-free radicals (OFRs) produced during ischemia and reperfusion (IR) have been implicated as the final common pathway in the pathogenesis of this syndrome. Spin traps have been shown to decrease IR injury in several animal lung models. The hydroxylamine, OXANOH (2-ethyl-2,5,5-trimethyl-3-oxazolidine) has been proposed as an ideal spin trap that would trap extra- and intracellular OFRs producing the stable radical, OXANO(center dot) (2-ethyl-2,5,5-trimethyl-3-oxazolidinoxyl). Electron microscopy was used to investigate whether OXANOH would protect against IR injury in the rabbit lung. Methods: OXANOH was obtained by hydrogenation of its stable radical, OXANO(center dot) using a safe laboratory technique. Several doses of OXANOH were tested to identify a nontoxic dose. Two quantitative methods were used based on the average surface area of the alveoli and average number of alveoli per unit surface area using scanning electron microscopy (SEM). A total of 20 animals were subjected to 2 hours of ischemia followed by 4 hours of reperfusion. On reperfusion, the 4 groups (N = 5) received no treatment, OXANOH, superoxide dismutase (SOD)/catalase, or oxypurinol. Results: A therapeutic dose of 250 mu mol/L of OXANO(center dot) was suggested in this in vitro model. All the 3 treatments showed significantly less injury compared to the control group and that SOD/catalase was significantly different from OXANOH and oxypurinol (P < .008). Conclusion: OXANOH ameliorated IR injury in the isolated rabbit lung, almost as effectively as SOD/catalase and oxypurinol. A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 34052-90-9. Computed Properties of C12H12N2O2.

Reference:
Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem

 

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 34052-90-9, Name is 1,3-Bis(4,5-dihydrooxazol-2-yl)benzene, molecular formula is C12H12N2O2. In an article, author is Kang, Jian,once mentioned of 34052-90-9, COA of Formula: C12H12N2O2.

Chiral dirhodium catalysts derived from L-serine, L-threonine and L-cysteine: design, synthesis and application

A series of dirhodium tetrakis((4S)-3-(arylsulfonyl)oxazolidine-4-carboxylate), dirhodium tetrakis((4S,5R)-5-methyl-3-(arylsulfonyl)oxazolidine-4-carboxylate) and dirhodium tetrakis((4R)-3-(arylsulfonyl)thiazolidine-4-carboxylate 1,1-dioxide) complexes with different para-substituted arylsulfonyl groups (e.g. -NO2, -F, -CF3, -Me, -Bu-t, -OMe and -(C12H25)-C-n) derived from L-serine, L-threonine and L-cysteine, respectively, were prepared with yields in the range of 40-87% through refluxing ligands in water with Na4Rh2(CO3)(4). These chiral Rh(II) complexes have been fully characterized by EA, IR, UV-vis, NMR and specific rotation measurements. They are found to be effective chiral catalysts for asymmetric aziridination and cyclopropanation reactions in terms of reactivity and enantioselectivity. They are extremely stable and can be stored for a long period (at least 18 months) on the bench without adversely affecting their reactivity and selectivity. The heterocyclic rings as well as the substituents on the arylsulfonyl groups have critical effects on the degree of asymmetric induction. In general, a higher enantioselectivity was observed in the reactions catalyzed by the oxazolidine-4-carboxylate-derived catalysts than the thiazolidine-4-carboxylate 1,1-dioxide-based catalysts. Among these 21 new Rh(II) catalysts, the uses of dirhodium tetrakis((4S)3-((4-dodecylphenyl)sulfonyl)oxazolidine-4-carboxylate) (Rh-2(4S-DOSO)(4)) and dirhodium tetrakis-((4S,5R)-5-methyl-3-((4-nitrophenyl)sulfonyl)oxazolidine-4-carboxylate) (Rh-2(4S,5R-MNOSO)(4)) resulted in the highest levels of enantioselectivity in aziridination (94% ee) and cyclopropanation (98% ee) of styrene, respectively. The successful design and syntheses of these novel Rh(II) complexes enlarged the scope of accessible chiral dirhodium(II) catalysts.

Interested yet? Keep reading other articles of 34052-90-9, you can contact me at any time and look forward to more communication. COA of Formula: C12H12N2O2.

Reference:
Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem

 

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 34052-90-9, Name is 1,3-Bis(4,5-dihydrooxazol-2-yl)benzene, molecular formula is C12H12N2O2. In an article, author is Jiang, Le,once mentioned of 34052-90-9, Computed Properties of C12H12N2O2.

Fluorescent Recognition of Functional Secondary Amines in the Fluorous Phase

In a fluorous solvent (perfluorohexane, FC-72), a perfluoroalkyl-substituted 2-hydroxy-1-naphthaldehyde (1) was found to show greatly enhanced fluorescence when treated with certain functional secondary amines but little fluorescence response was observed with unfunctional amines as well as functional primary and tertiary amines. The study of the reaction of 1 with 2-methylamino ethanol (8) reveals a facile cyclocondensation of the aldehyde group of 1 with this 1,2-amino alcohol to form a 5-membered ring oxazolidine product which turns on the fluorescence. The reaction of 1 with the amino alcohol was found to be more favorable in the fluorous solvent than in a common organic solvent. The use of the fluorous phase-based fluorescence measurement in this work provides a potentially more sensitive as well as selective method in amine sensing.

Interested yet? Keep reading other articles of 34052-90-9, you can contact me at any time and look forward to more communication. Computed Properties of C12H12N2O2.

Reference:
Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem

 

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, 34052-90-9, Name is 1,3-Bis(4,5-dihydrooxazol-2-yl)benzene, SMILES is C1(C2=NCCO2)=CC=CC(C3=NCCO3)=C1, belongs to oxazolidines compound. In a document, author is Murru, Siva, introduce the new discover, Product Details of 34052-90-9.

Fe-catalyzed synthesis of substituted N-aryl oxazolidines

A novel iron-catalyzed synthesis of substituted N-aryl oxazolidines was developed via C-N bond formation and methylenation. The reaction of aryl hydroxylamines with allyl alcohols, in the presence of formaldehyde or its equivalents, afforded variety of oxazolidine heterocycles in very good yields. This catalytic method is most effective for para-substituted aryl hydroxylamines and 3-methyl allyl alcohols. Furthermore, acid catalyzed demethylenation of oxazolidines allowed access to N-aryl amino alcohols in good yields.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 34052-90-9 is helpful to your research. Product Details of 34052-90-9.

Reference:
Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem

 

Chemistry is an experimental science, Formula: C12H12N2O2, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 34052-90-9, Name is 1,3-Bis(4,5-dihydrooxazol-2-yl)benzene, molecular formula is C12H12N2O2, belongs to oxazolidines compound. In a document, author is Fu, Ying.

CoMFA Study on Novel Substitute Oxazolidine Derivatives

A series of novel Substitute oxazolidine derivatives with potential herbicide safener activity has been modeled using a 3D quantitative structure-activity relationships approach known comparative molecular field analysis (CoMFA). The cross-validated q2 of CoMFA was 0.612, non-cross-validated R2 was 0.986, and F-test value was 120.1, respectively, with the biological activity of the compounds was expressed by pRC30 (root length). The results are critically discussed using a variety of statistical parameters. The CoMFA model was satisfactory and would be useful for the future design of new N-dichloroacetyl oxazolidine herbicide safener.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 34052-90-9, in my other articles. Formula: C12H12N2O2.

Reference:
Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem

 

Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 34052-90-9, Name is 1,3-Bis(4,5-dihydrooxazol-2-yl)benzene, SMILES is C1(C2=NCCO2)=CC=CC(C3=NCCO3)=C1, in an article , author is He, Guangke, once mentioned of 34052-90-9, Product Details of 34052-90-9.

Selectfluor (TM)-catalyzed oxidative cyclization of ynamides enables facile synthesis of oxazolidine-2,4-diones

A Selectfluor (TM)-catalyzed oxidative cyclization of ynamides affording oxazolidine-2,4-diones in yields from 69%-94% is described. The reaction is run under air and exhibits excellent chemo-selectivity and functional group compatibility. Preliminary mechanistic studies reveal that the solvent DMSO acts as an oxidant, and the redox reaction of Selectfluor (TM) with DMSO generates the real active catalyst HBF(4)in situ.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 34052-90-9, you can contact me at any time and look forward to more communication. Product Details of 34052-90-9.

Reference:
Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem

 

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 34052-90-9, Name is 1,3-Bis(4,5-dihydrooxazol-2-yl)benzene, molecular formula is C12H12N2O2. In an article, author is Hariono, Maywan,once mentioned of 34052-90-9, Name: 1,3-Bis(4,5-dihydrooxazol-2-yl)benzene.

2-Bromo-4-(3,4-dimethyl-5-phenyl-1,3-oxazolidin-2-yl)-6-methoxyphenol

In the title compound, C18H20BrNO3, the oxazolidine ring adopts an envelope conformation with the N atom at the flap position. The mean plane of oxazolidine ring makes dihedral angles of 82.96 (13) and 70.97 (12)degrees, respectively, with the phenyl and benzene rings. In the crystal, adjacent molecules are connected via O-H center dot center dot center dot O and C-H center dot center dot center dot O hydrogen bonds and C-H center dot center dot center dot pi interactions into a zigzag chain along the b axis.

Interested yet? Keep reading other articles of 34052-90-9, you can contact me at any time and look forward to more communication. Name: 1,3-Bis(4,5-dihydrooxazol-2-yl)benzene.

Reference:
Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem

 

Electric Literature of 34052-90-9, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 34052-90-9, Name is 1,3-Bis(4,5-dihydrooxazol-2-yl)benzene, SMILES is C1(C2=NCCO2)=CC=CC(C3=NCCO3)=C1, belongs to oxazolidines compound. In a article, author is Silva, Sandrina, introduce new discover of the category.

N-Thiocarbonyl Iminosugars: Synthesis and Evaluation of Castanospermine Analogues Bearing Oxazole-2(3H)-thione Moieties

A straightforward and efficient synthetic route to a new class of glycosidase inhibitors containing an oxazole-2(3H)-thione moiety has been devised. The approach involves the formation of -hydroxy ketones, which, after condensation with thiocyanic acid, leads to the formation of the heterocycle. By exploiting the ability of the nitrogen atom of oxazoline-2-thione precursors to act as nucleophiles in intramolecular addition, castanospermine analogues could be readily prepared in good overall yields. Glycosidase inhibitory activity compared to oxazolidinethione analogues showed a strong influence of the double bond, for example with pseudoiminosugar 19, by suppressing -glucosidase inhibition and introducing, to a moderate level, -glucosidase inhibitory activity. Reactivities showed the propensity of oxazole-2(3H)-thiones – especially when fused on carbohydrate frames – to convert into 1,3-oxazolidine-2-thione aminals through nucleophilic addition to the double bond, leading to unexpected tricyclic structure 21.

Electric Literature of 34052-90-9, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 34052-90-9.

Reference:
Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem

 

Chemistry is an experimental science, Computed Properties of C12H12N2O2, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 34052-90-9, Name is 1,3-Bis(4,5-dihydrooxazol-2-yl)benzene, molecular formula is C12H12N2O2, belongs to oxazolidines compound. In a document, author is Cruz-Hurtado, Marycarmen.

In vitro phase I metabolism of vinclozolin by human liver microsomes

1. Vinclozolin (Vin) is a fungicide used in agricultural settings and is classified as an endocrine disruptor. Vin is non-enzymatically hydrolyzed to 2-[[(3,5-dichlorophenyl)-carbamoyl]oxy]-2-methyl-3-butenoic acid (M1) and 3′,5′-dichloro-2-hydroxy-2-methylbut-3-enanilide (M2) metabolites. There is no information about Vin biotransformation in humans, therefore, the aim of this study was to characterize its in vitro metabolism using human liver microsomes. 2. Vin was metabolized to the [3-(3,5-dichlorophenyl)-5-methyl-5-(1,2-dihydroxyethyl)-1,3-oxazolidine-2,4-dione] (M4) and N-(2,3,4-trihydroxy-2-methyl-1-oxo)-3,5-dichlorophenyl-1-carbamic acid (M7) metabolites, which are unstable and gradually converted to 3 ‘,5 ‘-dichloro-2,3,4-trihydroxy-2-methylbutyranilide (DTMBA, formerly denoted as M5). M4 and DTMBA metabolites co-eluted in the same HPLC peak; this co-elute peak exhibited a Michaelis-Menten kinetic, whereas M7 showed a substrate inhibition kinetics. The K-M app for co-eluted M4/DTMBA and M7 was 24.2 +/- 5.6 and 116.0 +/- 52.6 mu M, the V-Max app was 0.280 +/- 0.015 and 0.180 +/- 0.060 nmoles/min/mg protein, and the CLint app was 11.5 and 1.5 mL/min/g protein, respectively. The K-i for M7 was 133.2 +/- 63.9 mu M. Cytochrome P450 (CYP) chemical inhibitors furafylline (CYP1A2), ketoconazole (CYP3A4), pilocarpine (CYP2A6) and sulfaphenazole (CYP2C9) inhibited M4/DTMBA and M7 formation, suggesting that Vin is metabolized in humans by CYP. 3. DTMBA is a stable metabolite and specific of Vin, therefore, it could be used as a biomarker of Vin exposure in humans to perform epidemiological studies.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 34052-90-9, in my other articles. Computed Properties of C12H12N2O2.

Reference:
Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem

 

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. COA of Formula: C12H12N2O2, 34052-90-9, Name is 1,3-Bis(4,5-dihydrooxazol-2-yl)benzene, SMILES is C1(C2=NCCO2)=CC=CC(C3=NCCO3)=C1, in an article , author is Na, Sang-Yun, once mentioned of 34052-90-9.

Fused oxazolidine-based dual optical probe for galactosidase with a dramatic chromogenic and fluorescence turn-on effect

A dual optical probe based on a fused oxazolidinoindocyanine moiety was prepared for detection of beta-galactosidase in the biological condition. The probe displayed both a dramatic colorless-to-red optical change and a fluorescence turn-on response in the visible region, exhibiting a high sensitivity for beta-galactosidase with a very low limit of detection (LOD = 0.071 U/L) in neutral PBS buffer. Published by Elsevier Ltd.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 34052-90-9, you can contact me at any time and look forward to more communication. COA of Formula: C12H12N2O2.

Reference:
Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem