Category: 189028-93-1

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Computed Properties of C20H18FNO4, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 189028-93-1, name is (S)-1-(4-Fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione. In an article，Which mentioned a new discovery about 189028-93-1

The invention provides an Ezetimibe synthesis method comprising the following steps: (a) a compound (5) is subjected to asymmetric reduction reaction to obtain a compound (6), and the compound (6) and tert-butyldimethylsilyl chloride react in an organic solution under the action of alkali to obtain a compound (7); (b) the compound (7) and diisopropylethylamine are dissolved in the organic solution, titanium tetrachloride is added in the organic solution to react at 20-50 DEG C, and a compound (3) is added in the organic solution at minus 20 to minus 60 DEG C to react to obtain a compound (8); (c) the compound (8) and N,O-bis(trimethylsilyl) acetamide react in the organic solution at 20-80 DEG C, tetrabutylammonium fluoride trihydrate is added into the organic solution to react at 20-80 DEG C to obtain a compound (9); (d) the compound (9) is subjected to off-protection reaction to obtain Ezetimibe, wherein R is equal to TBS, Ac or COOCH2CCl3. The invention further provides an Ezetimibe intermediate and a preparation method thereof.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 189028-93-1, help many people in the next few years.Computed Properties of C20H18FNO4

Reference：
Oxazolidine – Wikipedia,
Oxazolidine | C3H2792NO – PubChem

 

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. Safety of (S)-1-(4-Fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione. Introducing a new discovery about 189028-93-1, Name is (S)-1-(4-Fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione

A process is provided for preparing azetidinones useful as intermediates in the synthesis of penems and as hypocholesterolemic agents, comprising reacting a beta-(substituted-amino)amide, a beta-(substituted-amino)acid ester, or a beta-(substituted-amino)thiolcarbonic acid ester with a silylating agent and a cyclizing agent selected from the group consisting of alkali metal carboxylates, quaternary ammonium carboxylates, quaternary ammonium hydroxides, quaternary ammonium alkoxides, quaternary ammonium aryloxides and hydrates thereof, or the reaction product of: (i) at least one quaternary ammonium halide and at least one alkali metal carboxylate; or (ii) at least one quaternary ammonium chloride, quaternary ammonium bromide, or quaternary ammonium iodide and at least one alkali metal fluoride, wherein a quaternary ammonium moiety of the cyclizing agent is unsubstituted or substituted by one to four groups independently selected from the group consisting of alkyl, arylalkyl and arylalkyl-alkyl.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Safety of (S)-1-(4-Fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione, you can also check out more blogs about189028-93-1

Reference：
Oxazolidine – Wikipedia,
Oxazolidine | C3H2810NO – PubChem

 

Chemistry is traditionally divided into organic and inorganic chemistry. COA of Formula: C20H18FNO4, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent，Which mentioned a new discovery about 189028-93-1

The present invention discloses a therapeutic agent for hyperlipidemia according to booklet of the mai bu preparation method, which belongs to the field of drug synthesis. In order to compound 2 as raw materials, through the oxo protection, cyclization, carbonyl reduction, oxidation and the like four-step synthesis step preparation according to their folds mai bu 1. Compared with the prior literature reported method, which avoids the use of natural titanium reagent, the synthesis step is reduced, the process stability is higher, and is suitable for mass production. (by machine translation)

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Reference：
Oxazolidine – Wikipedia,
Oxazolidine | C3H2791NO – PubChem

 

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. name: (S)-1-(4-Fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione. Introducing a new discovery about 189028-93-1, Name is (S)-1-(4-Fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione

The present invention discloses a therapeutic agent for hyperlipidemia according to booklet of the mai bu preparation method, which belongs to the field of drug synthesis. In order to compound 2 as raw materials, through the oxo protection, cyclization, carbonyl reduction, hydrogenation deprotected four-step synthesis step preparation according to their folds mai bu 1. Compared with the prior literature reported method, which avoids the use of natural titanium reagent, the synthesis step is reduced, the process stability is higher, and is suitable for mass production. (by machine translation)

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.name: (S)-1-(4-Fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione, you can also check out more blogs about189028-93-1

Reference：
Oxazolidine – Wikipedia,
Oxazolidine | C3H2790NO – PubChem

 

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, category: oxazolidine, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 189028-93-1, Name is (S)-1-(4-Fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione, molecular formula is C20H18FNO4

An efficient and scalable process for the synthesis of antihypercholesterolemic drug ezetimibe through chiral Evans auxiliary (S)-4-phenyl-2-oxazolidinone is described. The key steps in this process are the condensation of (S)-3-(5-(4-fluorophenyl)-5,5-dimethoxypentanoyl)-4-phenyloxazolidin-2-one and N-(4-((tert-butyldimethylsilyl)oxy)benzylidene)-4-fluoroaniline, and the stereoselective reduction of ezetimibe-ketone with NaBH4/I2, which is first applied in the synthesis of ezetimibe. The process is concise, mild, easy to operate, and highly stereoselective (99.6% of de value of ezetimibe). In addition, three diastereomers of ezetimibe are synthesized and served as the references in quality control of the product.

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, category: oxazolidine, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 189028-93-1

Reference：
Oxazolidine – Wikipedia,
Oxazolidine | C3H2821NO – PubChem

 

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Computed Properties of C20H18FNO4, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 189028-93-1, name is (S)-1-(4-Fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione. In an article，Which mentioned a new discovery about 189028-93-1

KETOREDUCTASE POLYPEPTIDES FOR THE STEREOSELECTIVE PRODUCTION OF (4S)-3-[(5S)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE

The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme including the capability of reducing 5-((4S)-2-oxo-4-phenyl(1,3-oxazolidin-3-yl))-1-(4-fluorophenyl)pentane-1,5-dione to (4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize the intermediate (4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one in a process for making Ezetimibe.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 189028-93-1, help many people in the next few years.Computed Properties of C20H18FNO4

Reference：
Oxazolidine – Wikipedia,
Oxazolidine | C3H2802NO – PubChem

 

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. category: oxazolidine, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 189028-93-1, name is (S)-1-(4-Fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione. In an article，Which mentioned a new discovery about 189028-93-1

Synthesis of 3H, 14C and 13C6 labelled Sch 58235

3H-Sch 58235 was prepared at a specific activity of 29.1 Ci/mmol by Ir(COD)(Cy3P)PyPF6 catalysed exchange with tritium gas. 14C-Sch 58235 was prepared in three steps from p-hydroxy[ring-U-14C]benzaldehyde with an overall radiochemical yield of 21%. 13C6-Sch 58235 was similarly prepared in three steps from p-hydroxy[ring-U-13C6]benzaldehyde in an overall yield of 41%. Copyright

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 189028-93-1, help many people in the next few years.category: oxazolidine

Reference：
Oxazolidine – Wikipedia,
Oxazolidine | C3H2818NO – PubChem

 

Application of 189028-93-1, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.189028-93-1, Name is (S)-1-(4-Fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione, molecular formula is C20H18FNO4. In a article，once mentioned of 189028-93-1

Asymmetric synthesis of optically active methyl-2-benzamido-methyl-3-hydroxy-butyrate by robust short-chain alcohol dehydrogenases from Burkholderia gladioli

Three short-chain alcohol dehydrogenases from Burkholderia gladioli were discovered for their great potential in the dynamic kinetic asymmetric transformation of methyl 2-benzamido-methyl-3-oxobutanoate, and their screening against varied organic solvents and substrates. This is the first report of recombinant enzymes capable of achieving this reaction with the highest enantio- and diastereo-selectivity.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 189028-93-1

Reference：
Oxazolidine – Wikipedia,
Oxazolidine | C3H2815NO – PubChem

 

Synthetic Route of 189028-93-1, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 189028-93-1, Name is (S)-1-(4-Fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione, molecular formula is C20H18FNO4. In a Patent，once mentioned of 189028-93-1

A process for the preparation of intermediates according to Mai Bu (by machine translation)

The invention discloses a method for the preparation of intermediates according to Mai Bu, the intermediate body is (S) – 1 – (4-fluoro phenyl) – 5 – (2-oxo-4-phenyl-oxazolidine-3-yl) pentane -1,5-diketone, by 1 – (4-fluoro phenyl) ethanone and silane protective agent reaction generating ((1 – (4-fluoro phenyl) vinyl) oxygen) trimethyl silane, in addition acryloyl chloride and (S) – 4-phenyl-oxazolidine-2-ketone reaction condensation to obtain (S) – 3-acryloyl-4-phenyl-oxazolidine-2-one, then the ((1 – (4-fluoro phenyl) vinyl) oxygen) trimethyl silane and (S) – 3-acryloyl-4-phenyl-oxazolidine-2-one obtained through the condensation reaction. The process route is the route convergence devices, to achieve the overall yield of 80% or more, process the raw materials is cheap and easy to obtain, with the solvent, low toxicity, production cycle is short, the production cost is cheap, simple operation the production unit, safety and environmental protection, is very suitable for industrial production. (by machine translation)

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Synthetic Route of 189028-93-1. In my other articles, you can also check out more blogs about 189028-93-1

Reference：
Oxazolidine – Wikipedia,
Oxazolidine | C3H2812NO – PubChem

 

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Formula: C20H18FNO4, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 189028-93-1, Name is (S)-1-(4-Fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione, molecular formula is C20H18FNO4

According to booklet mai bu synthesis of intermediates method (by machine translation)

The invention discloses a according to the method for synthesizing intermediate folds mai bu, comprises the following steps: in under the nitrogen atmosphere, of formula (2) compound are added to in tetrahydrofuran to obtain solution A, A the solution temperature to 5 C to 10 C, and to the solution of (-) – A dropping two different pine pinane base chlorine borane, stirring the reaction, after the reaction is finished to obtain solution B, the solution B cooling to – 20 C to 0 C, aqueous solution of […], adjusting solution B of pH=5 – 8, the ethyl acetate extract adjusting pH of the solution B, evaporate ethyl acetate to obtain the residue C, to the remainder of the organic solvent is added in the C, standing, pouring the organic solvent, the residue obtained D, D to the residue in toluene is added to obtain solution E, heating and stirring solution after E, natural cooling, the solution is put into the freezing environment in E, filtering, drying formula (1) compound of the solid, the method is simple and easy, and the cost is low. The reaction is shown as follows: (by machine translation)

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, Formula: C20H18FNO4, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 189028-93-1

Reference：
Oxazolidine – Wikipedia,
Oxazolidine | C3H2799NO – PubChem