Category: 184363-66-4

184363-66-4, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 184363-66-4, Name is (S)-4-Phenyl-3-propionyloxazolidin-2-one, molecular formula is C12H13NO3. In a Article, authors is Perry, Matthew A.£¬once mentioned of 184363-66-4

Absolute configuration of lactams and oxazolidinones using kinetic resolution catalysts

A simple method for determining the absolute configuration of oxazolidinones, lactams, and their derivatives using kinetic resolution catalysts is described. The optically pure substrates were acylated using the (S)-HBTM and the (R)-HBTM catalyst, and the faster reaction was determined. An empirical mnemonic was developed for the assignment of the absolute configuration based on the fast-reacting catalyst.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.184363-66-4. In my other articles, you can also check out more blogs about 184363-66-4

Reference£º
Oxazolidine – Wikipedia,
Oxazolidine | C3H2267NO – PubChem

 

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.184363-66-4,(S)-4-Phenyl-3-propionyloxazolidin-2-one,as a common compound, the synthetic route is as follows.

General procedure: (S) -4-benzyl-3-propionyloxazolidinone (16.5 g, 1.1 eq)Was dissolved in 40 ml of dichloromethane, cooled to 0 C,A solution of titanium tetrachloride (14 g, 1.1 eq) in dichloromethane was added dropwise,After the drop, keep stirring below 0 C for 10 min.Diisopropylethylamine (9.7 g, 1.1 eq) was added dropwise,After the drop, keep stirring below 0 C for 30 min. The compound (II-b) (30 g, 1 equiv)Dissolved in methylene chloride, added dropwise to the reaction system,After the dropwise addition, the mixture was stirred at 20 to 25 C for 10 hours.To the reaction system, an aqueous solution of saturated ammonium chloride was added,Extracted with dichloromethane, and the resulting organic phases were washed with water and water, respectivelyWashed with saturated brine and dried over anhydrous sodium sulfate.The solvent was removed by evaporation under reduced pressure to give the crude product. The crude product was purified by column chromatography,To give the title compound (IV-a) (33.9 g, yield 91%).HPLC detection, no enantiomeric detection, that is, chiral purity of 100%., 184363-66-4

184363-66-4 (S)-4-Phenyl-3-propionyloxazolidin-2-one 226270, aoxazolidine compound, is more and more widely used in various fields.

Reference£º
Patent; Zhejiang Yongning Pharmaceutical Co., Ltd.; Ye Tianjian; Lu Xiuwei; Yu Guangliang; Liu Ting; (14 pag.)CN105085322; (2017); B;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

 

184363-66-4, (S)-4-Phenyl-3-propionyloxazolidin-2-one is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Weigh 2.2 g (10 mmol) of oxazolone ester (Formula VIII, R1 = phenyl, R2 = R3 = hydrogen) with a magnetic stirrer,The thermometer and the dropping funnel were dissolved in 20 ml of dichloromethane and cooled to -10 C.1.7 g (10 mmol) of titanium tetrachloride was added in that order, and 2.6 ml of diisopropylethylamine (20 mmol) was added thereto, and the mixture was kept for 1 hour.2.1 g (10 mmol) of the compound of formula III was dissolved in 10 ml of dichloromethane.This solution was slowly added dropwise to the solution of oxazolone and further stirred at the same temperature for 30 minutes.The reaction was quenched by the addition of 10% aqueous citric acid.The mixture was stood still, the aqueous layer was extracted with 30 ml of dichloromethane, and the organic phase was washed with 30 ml of water.Dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure.40 ml of methyl tert-butyl ether was added to the residue, and the suspension thus obtained was stirred at 20 to 25 C for 10 minutes, and then the product was isolated by filtration.Drying under reduced pressure gave a pale yellow crystalline compound (IV, R1 = phenyl, R2 = R3 = hydrogen). Yield: 2.72 g (63%) Purity: 98.3%, 184363-66-4

184363-66-4 (S)-4-Phenyl-3-propionyloxazolidin-2-one 226270, aoxazolidine compound, is more and more widely used in various fields.

Reference£º
Patent; Ningbo Ainuo Pharmaceutical Technology Co., Ltd.; Zhang Xini; Zhou Tao; Xiong Zhigang; Zhou Hao; Hu Tao; (9 pag.)CN108238981; (2018); A;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

 

184363-66-4, (S)-4-Phenyl-3-propionyloxazolidin-2-one is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(S) -4-benzyl-3-propionyloxazolidinone (16.5 g, 1.1 eq)Was dissolved in 40 ml of dichloromethane, cooled to 0 C,A solution of titanium tetrachloride (14 g, 1.1 eq) in dichloromethane was added dropwise,After the drop, keep stirring below 0 C for 10 min.Diisopropylethylamine (9.7 g, 1.1 eq) was added dropwise,After the drop, keep stirring below 0 C for 30 min. The compound (II-b) (30 g, 1 equiv)Dissolved in methylene chloride, added dropwise to the reaction system,After the dropwise addition, the mixture was stirred at 20 to 25 C for 10 hours.To the reaction system, an aqueous solution of saturated ammonium chloride was added,Extracted with dichloromethane, and the resulting organic phases were washed with water and water, respectivelyWashed with saturated brine and dried over anhydrous sodium sulfate.The solvent was removed by evaporation under reduced pressure to give the crude product. The crude product was purified by column chromatography,To give the title compound (IV-a) (33.9 g, yield 91%).HPLC detection, no enantiomeric detection, that is, chiral purity of 100%., 184363-66-4

As the paragraph descriping shows that 184363-66-4 is playing an increasingly important role.

Reference£º
Patent; Zhejiang Yongning Pharmaceutical Co., Ltd.; Ye Tianjian; Lu Xiuwei; Yu Guangliang; Liu Ting; (14 pag.)CN105085322; (2017); B;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem