With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17016-83-0,(S)-4-Isopropyl-2-oxazolidinone,as a common compound, the synthetic route is as follows.
REFERENCE EXAMPLE 19 (S)4-(1-Methylethyl)-3-(1-oxo-3-phenylpropyl)-2-oxazolidinone To a solution of 2.5 g of (4S)4-isopropyl-2-oxazolidinone in 60 ml of dry tetrahydrofuran under argon, cooled to -78 C. was added 8 ml n-butyllithium (2.5M in hexane). The suspension was allowed to warm slowly to 0 C. and then cooled to -78 C. (total time 50 minutes). To the well stirred suspension was added dropwise 3.3 ml of 3-phenylpropionyl chloride. The resulting solution was stirred at -78 C. for 2 hours and at 0 C. for 0.5 hour. To the solution was added 20 ml of saturated sodium bicarbonate and mixture concentrated under reduced pressure. The suspension was diluted with 20 ml of water and extracted with 150 ml of ethyl acetate. The extract was washed with brine, dried (Na2 SO4) and the solvent removed to give 5.67 g of colorless oil. This oil crystallized on standing and the crystals were triturated with hexane to give 5.0 g of crystals; [alpha]D26 +71+-1 (c, 1.182, CHCl3).
The synthetic route of 17016-83-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; American Cyanamid Company; US5104869; (1992); A;,
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