Category: 169048-83-3

Brief introduction of 169048-83-3

169048-83-3, The synthetic route of 169048-83-3 has been constantly updated, and we look forward to future research findings.

169048-83-3, (S)-5-(Chloromethyl)oxazolidin-2-one is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of (5S)-5-(chloromethyl)-l,3-oxazolidin-2-one (2.15 g, INTERMEDIATE 4), 2- bromo-5-chloropyridine (3.05 g), cesium carbonate (20.67 g), bispalladium tribenzylideneacetone (2.18 g) and (9,9-dimethyl-9H-xanthene-4,5-diyl)bis(diphenylphosphine) (2.07 g) in 16 ml of dioxane was stirred at 850C for 12 h. The sample was then cooled to room temperature, and purified was purified via column chromatography (2x) on a Biotage Horizon 65i column eluting with 0% ethyl acetate in hexanes (1 column volumes), followed by a gradient to 60% ethyl acetate in hexanes (over 10 column volumes), and held at 60% ethyl acetate for 4 column volumes to provide the title compound (2.44 g, 61%).

169048-83-3, The synthetic route of 169048-83-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MERCK & CO., INC.; WO2008/156718; (2008); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

 

Downstream synthetic route of 169048-83-3

169048-83-3, As the paragraph descriping shows that 169048-83-3 is playing an increasingly important role.

169048-83-3, (S)-5-(Chloromethyl)oxazolidin-2-one is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(S)-6(21.7 mg, 160 mumol) in N,N-dimethylformamide (DMF)(4.0 mL) was added to a solution of 4 (43.5 mg, 123 mumol).K2CO3 (204 mg, 1.48 mmol) was added, and the reactionmixture was stirred at 140C for 45 min. The mixture wasfiltered, and the filtrate was diluted with H2O (5 mL) and thenextracted with CHCl3 (3¡Á30 mL). The combined extract waswashed with brine (20 mL), dried, and concentrated in vacuoto give a residue (60 mg). Chromatography on a silica gel columnwith n-hexane-EtOAc (1 : 2-1 : 1) as the eluent gave (S)-1(26.8 mg, 48%) as a colorless powder. 1H-NMR (400 MHz,CDCl3) delta: 7.35 (2H, s), 5.79 (1H, br), 5.02 (1H, ddt, J=8.7, 6.2,5.0 Hz), 4.82 (1H, br), 4.20 (2H, d, J=5.0 Hz), 3.91 (1H, dd,J=8.7, 6.2 Hz), 3.82 (1H, t, J=8.7 Hz), 3.67 (3H, s), 3.39 (2H, q,J=6.7 Hz), 2.74 (2H, t, J=6.7 Hz). HR-FAB-MS m/z 450.9498[M+H]+ (Calcd for C14H17Br2N2O5: 450.9504). [alpha]D25 +21.4(c=0.1, MeOH).

169048-83-3, As the paragraph descriping shows that 169048-83-3 is playing an increasingly important role.

Reference£º
Article; Sirimangkalakitti, Nachanun; Yokoya, Masashi; Chamni, Supakarn; Chanvorachote, Pithi; Plubrukrn, Anuchit; Saito, Naoki; Suwanborirux, Khanit; Chemical and Pharmaceutical Bulletin; vol. 64; 3; (2016); p. 258 – 262;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem