Category: 169048-83-3

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Quality Control of (S)-5-(Chloromethyl)oxazolidin-2-one, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 169048-83-3, Name is (S)-5-(Chloromethyl)oxazolidin-2-one, molecular formula is C4H6ClNO2

Design and synthesis of 2-amino-6-(1H,3H-benzo[de]isochromen-6-yl)-1,3,5- triazines as novel Hsp90 inhibitors

A novel series of 2-amino-1,3,5-triazines bearing a tricyclic moiety as heat shock protein 90 (Hsp90) inhibitors is described. Molecular design was performed using X-ray cocrystal structures of the lead compound CH5015765 and natural Hsp90 inhibitor geldanamycin with Hsp90. We optimized affinity to Hsp90, in vitro cell growth inhibitory activity, water solubility, and liver microsomal stability of inhibitors and identified CH5138303. This compound showed high binding affinity for N-terminal Hsp90alpha (Kd = 0.52 nM) and strong in vitro cell growth inhibition against human cancer cell lines (HCT116 IC50 = 0.098 muM, NCI-N87 IC50 = 0.066 muM) and also displayed high oral bioavailability in mice (F = 44.0%) and potent antitumor efficacy in a human NCI-N87 gastric cancer xenograft model (tumor growth inhibition = 136%).

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Oxazolidine – Wikipedia,
Oxazolidine | C3H1403NO – PubChem

 

Synthetic Route of 169048-83-3, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 169048-83-3, Name is (S)-5-(Chloromethyl)oxazolidin-2-one,introducing its new discovery.

Electrochemical oxidation of chiral 5-substituted 2-oxazolidinones: A key building block for dichiral beta-amino alcohols

The 4-methoxylation of some chiral 5-substituted 2-oxazolidinones can be performed successfully by direct electrochemical oxidation el 50 mA/cm2 in methanol at graphite electrodes using an undivided or quasi-divided cell and sodium tetrafluoroborate or sodium benzene sulfonate as supporting electrolytes. The yields and selectivities are depending on the pH of the solution and the concentration of the substrate. Thus, (4RS,5S)- chloromethyl-4-methoxy-2-oxazolidinone (7) could be obtained in 76% yield from (5S)-chloromethyl-2-oxazolidinone (3). Through nucleophilic methoxy- group exchange these heterocycles are key intermediates for enantiomerically pure trans-4,5-difunctionalized-2-oxazolidinones in both enantiomeric forms, which are very interesting targets due to their various pharmacological effects and as precursors for beta-amino alcohols and protease inhibitors.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H1394NO – PubChem

 

Synthetic Route of 169048-83-3, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.169048-83-3, Name is (S)-5-(Chloromethyl)oxazolidin-2-one, molecular formula is C4H6ClNO2. In a Article£¬once mentioned of 169048-83-3

A facile Ph3P/CO2 mediated, one-pot synthesis of 2-oxazolidinones from 1, 2-azido alcohols via phosphazene and isocyanate intermediates

A facile, efficient and convenient method has been developed for the one-pot synthesis of 2-oxazolidinones from the corresponding 1, 2-azido alcohols via phosphazene and isocyanate intermediates in presence of Ph 3P/CO2 in toluene.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 169048-83-3

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Oxazolidine – Wikipedia,
Oxazolidine | C3H1400NO – PubChem

 

Reference of 169048-83-3, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.169048-83-3, Name is (S)-5-(Chloromethyl)oxazolidin-2-one, molecular formula is C4H6ClNO2. In a article£¬once mentioned of 169048-83-3

Electrogenerated chiral 4-methoxy-2-oxazolidinones as diastereoselective amidoalkylation reagents for the synthesis of beta-amino alcohol precursors

A flexible and efficient synthesis of enantiomerically pure 4,5-substituted 2-oxazolidinones – important target molecules as precursors of pharmacologically active 2-oxazolidinones, beta-amino alcohols, beta-blockers and azasugar derivatives – is described. As starting materials, the enantiopure storage forms of chiral N-acyliminium ions (4RS,5S)-5-chloromethyl-4-methoxy-1,3-oxazolidin-2-one (2) and (4RS,5R)-4-methoxy-5-methyl-1,3-oxazolidin-2-one (3) were used; these are readily available from the chiral pool with the aid of electrochemical transformations. Substitution of the 4-methoxy group in building blocks 2 and 3 with a large variety of organometallic nucleophiles resulted in the trans-diastereoselective formation of enantiopure 4,5-disubstituted 2-oxazolidinones, with a high degree of flexibility in the substituent at the 4-position.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 169048-83-3

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Oxazolidine – Wikipedia,
Oxazolidine | C3H1401NO – PubChem

 

169048-83-3, Name is (S)-5-(Chloromethyl)oxazolidin-2-one, belongs to oxazolidine compound, is a common compound. Safety of (S)-5-(Chloromethyl)oxazolidin-2-oneIn an article, once mentioned the new application about 169048-83-3.

Enzymatic ammonolysis of ethyl (¡À)-4-chloro-3-hydroxybutanoate. Chemoenzymatic syntheses of both enantiomers of pyrrolidin-3-ol and 5- (chloromethyl)-1,3-oxazolidin-2-one

Lipase B from Candida antarctica efficiently catalysed the kinetic resolution of ethyl (¡À)-4-chloro-3-hydroxybutanoate through an ammonolysis reaction. Using this methodology, both enantiomers of 4-chloro-3- hydroxybutanamide were prepared and converted into pyrrolidin-3-ol and 5- (chloromethyl)-1,3-oxazolidin-2-one by simple processes consisting of a reduction reaction and a Hofmann rearrangement, respectively.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H1397NO – PubChem

 

Synthetic Route of 169048-83-3, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 169048-83-3, Name is (S)-5-(Chloromethyl)oxazolidin-2-one, molecular formula is C4H6ClNO2. In a Article£¬once mentioned of 169048-83-3

Electrogenerated chiral building blocks for diastereoselective amidoalkylation reactions

Three different electrochemical methods have been applied for the synthesis of chiral building blocks for diastereoselective amidoalkylation reactions. These are A. the direct anodic alpha-methoxylation of amides and carbamates; B. anodic methoxylative decarboxylation of alpha-amino acid derivatives (Hofer-Moest reaction) C. indirect NaCl mediated anodic alpha-methoxylation of alpha-amino acid derivatives. The application of these building blocks for the synthesis of enantiomerically pure alpha-amino acids, dichiral 1,2-amino alcohols and chiral 1,3-diamines is described.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Synthetic Route of 169048-83-3. In my other articles, you can also check out more blogs about 169048-83-3

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Oxazolidine – Wikipedia,
Oxazolidine | C3H1392NO – PubChem

 

Reference of 169048-83-3, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 169048-83-3, Name is (S)-5-(Chloromethyl)oxazolidin-2-one, molecular formula is C4H6ClNO2. In a Article£¬once mentioned of 169048-83-3

Synthesis and absolute configuration of acanthodendrilline, a new cytotoxic bromotyrosine alkaloid from the Thai marine sponge acanthodendrilla sp.

Acanthodendrilline (1), a new bromotyrosine alkaloid, was isolated from the Thai marine sponge Acanthodendrilla sp. The structure of 1 was fully characterized by spectroscopic analysis, in agreement with the synthesized compound used to resolve the single chiral center at C-11. Total synthesis of the enantiomers of 1 allowed for the comparison of specific rotation values and hence the determination of the absolute configuration as 11-S. Cytotoxicity evaluation revealed that (S)-1 exhibited approximately three-fold more potent cytotoxicity against the human non-small cell lung cancer H292 cell line than (R)-1.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Reference of 169048-83-3. In my other articles, you can also check out more blogs about 169048-83-3

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Oxazolidine – Wikipedia,
Oxazolidine | C3H1402NO – PubChem

 

Chemistry is traditionally divided into organic and inorganic chemistry. Application In Synthesis of (S)-5-(Chloromethyl)oxazolidin-2-one, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 169048-83-3

A three-step synthesis of optically active 5-halomethyl-2-oxazolidinones; asymmetric desymmetrization of prochiral 1,3-dihalo-2-propyl carbamates

Optically active 5-bromomethyl-2-oxazolidinones (2a and 3a) and 5-chloromethyl-2-oxazolidinones (2b and 3b) were readily prepared from prochiral 1,3-dibromo-2-propanol (7a) and 1,3-dichloro-2-propanol (7b) by a three-step sequence involving formation of carbamates (6a-c) followed by asymmetric desymmetrization (up to 50% de) and debenzylation by anisole-methanesulfonic acid system.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H1404NO – PubChem

 

169048-83-3, In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 169048-83-3, name is (S)-5-(Chloromethyl)oxazolidin-2-one, introducing its new discovery.

CETP INHIBITORS DERIVED FROM BENZOXAZOLE ARYLAMIDES

Compounds having the structure of Formula I, including pharmaceutically acceptable salts of the compounds, are potent CETP inhibitors, and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis. In formula I, A-B is an arylamide moiety.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.169048-83-3, you can also check out more blogs about169048-83-3

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Oxazolidine – Wikipedia,
Oxazolidine | C3H1391NO – PubChem

 

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.169048-83-3,(S)-5-(Chloromethyl)oxazolidin-2-one,as a common compound, the synthetic route is as follows.

General procedure: To the solution of 4-amino-6-{7-chloro-3-oxatricyclo[7.3.1.05,13]trideca-1(13),5,7,9,11-pentaen-8-yl}-1,3,5-triazine-2-thiol (17, 399 mg, 1.21 mmol) and N-(2-chloroethyl)methanesulfonamide (381 mg, 2.41 mmol) in N,N-dimethylformamide (20 mL) was added N-ethyldiisopropylamine (631 muL, 3.14 mmol) at room temperature. The resulting mixture was stirred for 2.5 h at 70 C. After cooling to room temperature, the mixture was extracted between ethylacetate and water. The organic layer was washed with water and brine successively, dried over anhydrous magnesium sulfate, and filtered. The filtrate was concentrated by evaporation and the resulting residue was purified by preparative HPLC to give the title compound 62%, a light brown solid). H NMR (400 MHz, DMSO-d6) delta: 3.26 (1H, dd, J = 6.6, 8.8 Hz), 3.38 (1H, dd, J = 14.0, 6.0 Hz), 3.47 (1H, dd, J = 14.0, 6.0 Hz), 3.57 (1H, dd, J = 8.8, 8.8 Hz), 4.79-4. 87 (1H, m), 5.05 (2H, s), 5.06 (2H, s), 7.35 (1H, d, J = 7.1 Hz), 7.43 (1H, d, J = 8.8 Hz), 7.45 (1H, s), 7.53 (1H, dd, J = 8.8, 7.1 Hz), 7.57 (1H, s), 7.91 (2H, s). MS (ESI+) m/z: 430, 432 [M+H]+. HRMS (ESI+) m/z: [M+H]+ calcd for C19H1735ClN5O3S, 430.07351; found, 430.07277, [M+H]+ calcd for C19H1737ClN5O3S, 432.07056; found, 432.06954., 169048-83-3

169048-83-3 (S)-5-(Chloromethyl)oxazolidin-2-one 7058042, aoxazolidine compound, is more and more widely used in various fields.

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Article; Suda, Atsushi; Kawasaki, Ken-Ichi; Komiyama, Susumu; Isshiki, Yoshiaki; Yoon, Dong-Oh; Kim, Sung-Jin; Na, Young-Jun; Hasegawa, Kiyoshi; Fukami, Takaaki A.; Sato, Shigeo; Miura, Takaaki; Ono, Naomi; Yamazaki, Toshikazu; Saitoh, Ryoichi; Shimma, Nobuo; Shiratori, Yasuhiko; Tsukuda, Takuo; Bioorganic and Medicinal Chemistry; vol. 22; 2; (2014); p. 892 – 905;,
Oxazolidine – Wikipedia
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