Category: 168297-86-7

Montagnat, Oliver D.; Lessene, Guillaume; Hughes, Andrew B. published an article in 2010, the title of the article was Synthesis of Azide-alkyne Fragments for ‘Click’ Chemical Applications. Formation of Chiral 1,4-Disubstituted-(β-alkyl)-γ-1,2,3-triazole Scaffolds from Orthogonally Protected Chiral β-Alkyl-trialkylsilyl-γ-pentynyl Azides and Chiral β-Alkyl-γ-pentynyl-alcohols.Name: (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one And the article contains the following content:

A library of chiral γ-pentynyl alcs., I, and γ-pentynyl azides, e.g. II, was made using the SuperQuat chiral oxazolidin-2-one auxiliary. Coupling of the free alkynes with the azides by Huisgen 1,3-dipolar cycloaddition provided chiral oligomeric 1,4-disubstituted-1,2,3-triazoles, e.g. III, as possible peptidomimetic compounds The experimental process involved the reaction of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one(cas: 168297-86-7).Name: (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one

The Article related to asym alkylation chiral auxiliary pentynyl alc azide preparation, huisgen dipolar cycloaddition chiral pentynyl alc azide reactant, click chem disubstituted triazole preparation pentynyl alc azide reactant and other aspects.Name: (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

On September 7, 2007, Beddow, James E.; Davies, Stephen G.; Ling, Kenneth B.; Roberts, Paul M.; Russell, Angela J.; Smith, Andrew D.; Thomson, James E. published an article.SDS of cas: 168297-86-7 The title of the article was Asymmetric synthesis of β2-amino acids: 2-substituted-3-aminopropanoic acids from N-acryloyl SuperQuat derivatives. And the article contained the following:

Conjugate addition of lithium dibenzylamide to the SuperQuat derivative (S)-3-acryloyl-4-isopropyl-5,5-dimethyloxazolidin-2-one (derived from L-valine) and alkylation of the resultant lithium β-amino enolate provide, after deprotection, a range of (S)-2-alkyl-3-aminopropanoic acids in good yields and high enantiomeric excesses. Alternatively, conjugate addition of a range of secondary lithium amides to (S)-3-(2-alkylacryloyl)-4-isopropyl-5,5-dimethyloxazolidin-2-one SuperQuat derivatives, diastereoselective protonation with 2-pyridone, and subsequent deprotection furnish a range of (R)-2-alkyl- and (R)-2-aryl-3-aminopropanoic acids in good yields and high enantiomeric excesses. Addnl., the boron-mediated aldol reaction of β-amino N-acyloxazolidinones is a highly diastereoselective method for the synthesis of a range of β-amino-β’-hydroxy N-acyloxazolidinones. The experimental process involved the reaction of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one(cas: 168297-86-7).SDS of cas: 168297-86-7

The Article related to alkylaminopropanoic acid preparation conjugate addition alkylation, superquat derivative conjugate addition alkylation, oxazolidinone amino hydroxy acyl preparation, asym synthesis beta amino acid and other aspects.SDS of cas: 168297-86-7

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Campbell, Craig D.; Concellon, Carmen; Smith, Andrew D. published an article in 2011, the title of the article was Catalytic enantioselective Steglich rearrangements using chiral N-heterocyclic carbenes.Product Details of 168297-86-7 And the article contains the following content:

The evaluation of a range of enantiomerically pure NHCs, prepared in situ from imidazolinium or triazolium salt precatalysts, to promote the catalytic enantioselective Steglich rearrangement of oxazolyl carbonates I (R = Bn, Me, Et, CH2CHMe2, CH2C6H4OBn-4; R1 = Ph, Me, CMe2CCl3) to their C-carboxyazlactones II is reported. Modest levels of enantioselectivity (up to 66% ee) are observed using oxazolidinone derived NHCs. The experimental process involved the reaction of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one(cas: 168297-86-7).Product Details of 168297-86-7

The Article related to carboxyazlactone enantioselective preparation reaction mechanism, oxazolyl carbonate steglich rearrangement chiral n heterocyclic carbene catalyst, imidazolinium salt triazolium salt precatalyst and other aspects.Product Details of 168297-86-7

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

On December 13, 2019, Warner, Christopher J. A.; Berry, Sian S.; Jones, Simon published an article.Synthetic Route of 168297-86-7 The title of the article was Evaluation of bifunctional chiral phosphine oxide catalysts for the asymmetric hydrosilylation of ketimines. And the article contained the following:

A series of hydroxy-functionalized bifunctional phosphine oxides and diphosphine dioxides have been prepared and evaluated as catalysts for the trichlorosilane mediated asym. hydrosilylation of ketimines. Bis-Phosphine oxides, hydroxy-phosphine oxides, and biaryl phosphine oxides all demonstrated good catalytic activity, but poor to moderate enantioselectivity. A bis-P-chiral phosphine oxide (R,R)-Ph(2-MeOC6H4)P(CH2)6PPh(2-MeOC6H4) (32) displayed the highest enantioselectivity of 60%. The experimental process involved the reaction of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one(cas: 168297-86-7).Synthetic Route of 168297-86-7

The Article related to phosphine oxide hydroxy chiral preparation organocatalyst asym hydrosilylation ketimine, chiral aromatic amine preparation asym hydrosilylation organocatalyst phosphine oxide, diphosphine oxide phosphorus chiral preparation organocatalyst asym hydrosilylation ketimine and other aspects.Synthetic Route of 168297-86-7

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

On December 16, 2011, Adams, Harry; Collins, Rebecca C.; Jones, Simon; Warner, Christopher J. A. published an article.Electric Literature of 168297-86-7 The title of the article was Enantioselective preparation of P-chiral phosphine oxides. And the article contained the following:

A highly efficient chiral auxiliary-based strategy for the asym. synthesis of P-chiral phosphine oxides in >98:2 er has been developed. Racemic phosphinyl chlorides undergo highly stereoselective asym. substitution with N-deprotonated chiral oxazolidinones, yielding chiral phosphinic amides, which react with Grignard reagents, giving chiral phosphine oxides. The methodol. involves the highly stereoselective formation of P-chiral oxazolidinones that then undergo displacement with a variety of Grignard reagents to prepare the desired phosphine oxides. The experimental process involved the reaction of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one(cas: 168297-86-7).Electric Literature of 168297-86-7

The Article related to phosphine oxide chiral preparation oxazolidinone asym phosphinylation grignard reaction, substitution asym phosphinylation chiral auxiliary oxazolidinone phosphinic amide preparation, arylation alkylation phosphinic amide stereoselective preparation chiral phosphine oxide and other aspects.Electric Literature of 168297-86-7

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

On October 1, 2010, Lang, Kai; Park, Jongwoo; Hong, Sukwon published an article.COA of Formula: C8H15NO2 The title of the article was Development of Bifunctional Aza-Bis(oxazoline) Copper Catalysts for Enantioselective Henry Reaction. And the article contained the following:

Base-functionalized aza-bis(oxazoline) ligands were prepared to explore the concept of dual activation through the Lewis acid and a tethered tertiary amine base. The catalytic activity of the Cu complex was evaluated for the asym. Henry reaction. Compared with a corresponding unfunctionalized copper complex with external 1-benzyl-4-ethylpiperazine base, the ethylpiperazine-functionalized aza-bis(oxazoline) copper catalyst I resulted in rate acceleration (2.5 times) as well as improved enantioselectivity (72% ee vs 92% ee). The experimental process involved the reaction of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one(cas: 168297-86-7).COA of Formula: C8H15NO2

The Article related to chiral bifunctional bisoxazoline ligand preparation stereoselective henry reaction catalyst, aryl aldehyde copper chiral base functionalized ligand henry reaction, benzylic alc nitro derivative stereoselective preparation, henry reaction kinetic copper ligand base reaction order and other aspects.COA of Formula: C8H15NO2

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

On July 31, 2010, Bourcet, Emmanuel; Fache, Fabienne; Piva, Olivier published an article.Safety of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one The title of the article was Stereocontrolled Synthesis of the Highly Functionalized Core Structure of Aurisides by Ring-Closing Metathesis. And the article contained the following:

Two approaches based on the ring-closing metathesis reaction have been explored for the synthesis of the core structure I of the marine natural products, the aurisides. The second approach, accomplished in a stereocontrolled manner, used both a Brown’s allylation and an Evans’ aldolization, and finally a transannular ketalization to deliver a highly functionalized auriside analog. The experimental process involved the reaction of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one(cas: 168297-86-7).Safety of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one

The Article related to auriside core structure stereocontrolled synthesis ring closing metathesis, allylation brown stereocontrolled synthesis auriside core structure, evans aldolization stereocontrolled synthesis auriside core structure, transannular ketalization stereocontrolled synthesis auriside core structure and other aspects.Safety of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

On March 24, 2000, Fukuzawa, Shin-ichi; Matsuzawa, Hiroshi; Yoshimitsu, Shin-ichi published an article.Recommanded Product: (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one The title of the article was Asymmetric Samarium-Reformatsky Reaction of Chiral α-Bromoacetyl-2-oxazolidinones with Aldehydes. And the article contained the following:

The samarium(II) iodide mediated asym. Reformatskii-type reaction of chiral bromoacetyloxazolidinones I (R = Me2CH, Ph, PhCH2; R1 = H, Me, Ph) with various aldehydes R2CHO [R2 = Me2CH, Et2CH, c-C6H11, Me3C, Me(CH2)6, PhCH2CH2, Ph] was studied. A series of chiral 4-substituted 2-oxazolidinones and 5,5-disubstituted “SuperQuat” oxazolidinones were employed as chiral auxiliaries for α-bromoacetic acid. The reaction of I (R = Me2CH; R1 = H) with aldehydes R2CHO [R2 = Me2CH, Et2CH, c-C6H11, Me3C, Me(CH2)6, PhCH2CH2, Ph] gave β-hydroxy carboximides II [R = H; R1 = Me2CH; R2 = Me2CH, Et2CH, c-C6H11, Me3C, Me(CH2)6, PhCH2CH2, Ph] in 67-92% yields and in 64-99% diastereomeric excess. The majority of the reaction product derived from I (R = Me2CH; R1 = Ph) were highly crystalline; a single recrystallization of II [R = Me2CH; R1 = Ph; R2 = Me2CH, Me3C, Me(CH2)6, Ph] gave diastereomerically pure products with the β-hydroxy epimer not detectable by spectroscopic methods. The absolute configurations of the β-hydroxy carboximides were determined by comparison of the optical rotations of the corresponding known Et esters to the literature values. Hydrolytic cleavage of the appended β-hydroxy moieties from the auxiliary SuperQuats derivatives II (R = Me2CH; R1 = Me, Ph) was readily achieved under mild conditions using lithium hydroxide; the corresponding carboxylic acids and the returned SuperQuats were obtained in good yields without any evidence of racemization. The absolute configuration of the adduct derived from benzaldehyde was found to be R, with the samarium enolate formed by reduction of the bromoacetyl derivative favoring the transition state predicted from chelation control of the reagent; this is in analogy to the discussion that has been used for the corresponding titanium enolate. The stereochem. of the reaction may be explained by incorporating the Nerz-Stormes-Thornton chair transition structure model. The experimental process involved the reaction of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one(cas: 168297-86-7).Recommanded Product: (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one

The Article related to hydroxy acid nonracemic stereoselective preparation, ester beta hydroxy stereoselective preparation, hydroxyalkanoyl oxazolidinone stereoselective preparation, asym reformatskii reaction bromoacetyl oxazolidinone aldehyde, stereoselective reformatskii reaction bromoacetyl oxazolidinone aldehyde and other aspects.Recommanded Product: (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Tomas, Loic; Boije af Gennaes, Gustav; Hiebel, Marie Aude; Hampson, Peter; Gueyrard, David; Pelotier, Beatrice; Yli-Kauhaluoma, Jari; Piva, Olivier; Lord, Janet M.; Goekjian, Peter G. published an article in 2012, the title of the article was Total Synthesis of Bistramide A and Its 36(Z) Isomers: Differential Effect on Cell Division, Differentiation, and Apoptosis.Recommanded Product: 168297-86-7 And the article contains the following content:

The total synthesis of bistramide A and its 36(Z),39(S) and 36(Z),39(R) isomers shows that these compounds have different effects on cell division and apoptosis. The synthesis relies on a novel enol ether-forming reaction for the spiroketal fragment, a kinetic oxa-Michael cyclization reaction for the tetrahydropyran fragment, and an asym. crotonylation reaction for the amino acid fragment. Preliminary biol. studies show a distinct pattern of influence of each of the three compounds on cell division, differentiation, and apoptosis in HL-60 cells, thus suggesting that these effects are independent activities of the natural product. The experimental process involved the reaction of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one(cas: 168297-86-7).Recommanded Product: 168297-86-7

The Article related to bistramide a isomer preparation antitumor, cell division differentiation apoptosis differential effect bistramide a, enol ether formation total synthesis bistramide a isomer, kinetic oxa michal cyclization total synthesis bistramide a isomer, asym crotonylation total synthesis bistramide a isomer and other aspects.Recommanded Product: 168297-86-7

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

On October 28, 2004, Burke, Martin D.; Berger, Eric M.; Kwon, Ohyun; Park, Seung Bum; Schreiber, Stuart L. published a patent.Safety of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one The title of the patent was Generation of skeletal diversity within a combinatorial library. And the patent contained the following:

The present invention provides a method of synthesizing a library of chem. compounds with skeletal diversity. Two approaches are used to create skeletal diversity within a library of chem. compounds: (1) the “”branching pathways”” (or reagent-based) approach; and (2) the “”folding pathways”” (or substrate-based) approach. Upon exposure to certain reaction conditions the members of the library undergo unique transformations into a diverse collection of mol. skeletons, which can be functionalized and derivatized further to generate a large collection of unique, natural product-like compounds A furan-based library synthesized using the folding pathways approach is provided, and a polycyclic library created using the branching pathways approach is also provided. The invention also provides materials, reagents, intermediates, and kits useful in the practice of the inventive method as well as method for screening the inventive compounds The experimental process involved the reaction of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one(cas: 168297-86-7).Safety of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one

The Article related to oxazolidinone combinatorial library stereoselective preparation solid phase synthesis, split pool synthesis skeletal diversity combinatorial chem oxazolidinone preparation, combinatorial matrix mol skeleton furan derivatization, skeletal diversity branched diels alder polycyclic combinatorial library and other aspects.Safety of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem