Category: 168297-86-7

On February 3, 2003, Ortiz, Aurelio; Quintero, Leticia; Hernandez, Hector; Maldonado, Sotero; Mendoza, Guadalupe; Bernes, Sylvain published an article.Recommanded Product: 168297-86-7 The title of the article was (S)-4-Isopropyl-5,5-dimethyl-1,3-oxazolidinethione as chiral auxiliary for the intramolecular sulfur transfer in α,β-unsaturated N-acylimides, promoted by NbCl5. And the article contained the following:

The 1,3-oxazolidinethione was synthesized from (S)-valine and used in the intramol. S transfer in its N-enoyl derivatives in the presence of NbCl5 as catalyst, which, also, works as an indicator of the reaction. The adducts have subsequently been transformed into the corresponding β-mercapto esters by action of Sm(OTf)3 in MeOH. The experimental process involved the reaction of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one(cas: 168297-86-7).Recommanded Product: 168297-86-7

The Article related to oxazolidinethione preparation reactivity, crystal structure oxazolidinethione derivative, Heterocyclic Compounds (More Than One Hetero Atom): Oxazoles, Isoxazoles and other aspects.Recommanded Product: 168297-86-7

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Burkhardt, Immo; Lauterbach, Lukas; Brock, Nelson L.; Dickschat, Jeroen S. published an article in 2017, the title of the article was Chemical differentiation of three DMSP lyases from the marine Roseobacter group.Computed Properties of 168297-86-7 And the article contains the following content:

Dimethylsulfoniopropionate (DMSP) catabolism of marine bacteria plays an important role in marine and global ecol. The genome of Ruegeria pomeroyi DSS-3, a model organism from the Roseobacter group, harbors no less than three genes for different DMSP lyases (DddW, DddP and DddQ) that catalyze the degradation of DMSP to di-Me sulfide (DMS) and acrylate. Despite their apparent similar function these enzymes show no significant overall sequence identity. In this work DddQ and DddW from R. pomeroyi and the DddP homolog from Phaeobacter inhibens DSM 17395 were functionally characterized and their substrate scope was tested using several synthetic DMSP analogs. Comparative kinetic assays revealed differences in the conversion of DMSP and its analogs in terms of selectivity and overall velocity, giving addnl. insights into the mol. mechanisms of DMSP lyases and into their putatively different biol. functions. The experimental process involved the reaction of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one(cas: 168297-86-7).Computed Properties of 168297-86-7

The Article related to ruegeria dmsp lyase isoenzyme recognition substrate analog preparation kinetics, Enzymes: Substrates-Cofactors-Inhibitors-Activators-Coenzymes-Products and other aspects.Computed Properties of 168297-86-7

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

On October 31, 2014, Valeev, R. F.; Bikzhanov, R. F.; Miftakhov, M. S. published an article.Safety of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one The title of the article was Building blocks for (C15-C3)-modified epothilone D analogs. And the article contained the following:

A promising potentially biol. active structure have been designed by isosteric rearrangement of the C15-C3 fragment of epothilone D, and building blocks, e.g., I, necessary for its assembly have been synthesized. The experimental process involved the reaction of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one(cas: 168297-86-7).Safety of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one

The Article related to epothilone d building block preparation, Biomolecules and Their Synthetic Analogs: Other Bacterial and Fungal Metabolites and other aspects.Safety of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

On April 4, 2013, Cho, Young Shin; Levell, Julian Roy; Toure, Bakary-Barry; Yang, Fan; Caferro, Thomas; Lei, Huangshu; Lenoir, Francois; Liu, Gang; Palermo, Mark G.; Shultz, Michael David; Smith, Troy; Costales, Abran Q.; Pfister, Keith Bruce; Sendzik, Martin; Shafer, Cynthia; Sutton, James; Zhao, Qian published a patent.Synthetic Route of 168297-86-7 The title of the patent was 3-Pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant IDH and their preparation. And the patent contained the following:

The invention is directed to a compound of formula I or a pharmaceutically acceptable salt thereof, and to the use of such compounds in the inhibition of mutant IDH proteins having a neomorphic activity. Compounds of formula I wherein R1 and R2 are independently H, D, halo, OH, etc.; R3a is H, D, C1-6 alkyl, Ph, and benzyl; R3b is H, D, and C1-6 alkyl; R4a is H, C1-6 alkyl, (un)substituted Ph, (un)substituted benzyl, etc.; R4b is H, D, and C1-3 alkyl; R3aR3b or R4aR4b can be taken together to form (un)substituted 3- to 7-membered cycloalkyl and (un)substituted 4- to 7-membered heterocyclyl; R5a is H and D; R5b is H, D, Me, Et, CF3, CD3, etc.; R6 is (un)substituted C1-6 alkyl, (un)substituted heteroaryl, (un)substituted aryl, etc.; R5bR6 can be taken together to form (un)substituted C3-7 cycloalkyl, (un)substituted bicycloalkyl; and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by amination of (S)-3-(2-chloropyrimidin-4-yl)-5,5-dimethyl-4-phenyloxazolidin-2-one with (S)-(-)-1-phenylethanamine. All the invention compounds were evaluated for their IDH inhibitory activity. From the assay, it was determined that compound II exhibited IC50 values in the range of 0.084 μM to 0.236 μM. The experimental process involved the reaction of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one(cas: 168297-86-7).Synthetic Route of 168297-86-7

The Article related to pyrimidinyloxazolidinone preparation mutant idh inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Synthetic Route of 168297-86-7

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

On November 30, 2014, Valeev, Ruslan F.; Bikzhanov, Radmir F.; Miftakhov, Mansur S. published an article.Formula: C8H15NO2 The title of the article was Synthesis of the C6-C21 fragment of epothilone analogues. And the article contained the following:

(2S,4E,6Z,9S,10E)-9-[tert-Butyl(diphenyl)silyloxymethyl]-2,6,10-trimethyl-11-(2-methylthiazol-4-yl)undeca-4,6,10-trien-1-ol I, a key precursor for epothilone analogs, was prepared by multi-step synthesis using the Julia-Kocienski olefination at the key step. The experimental process involved the reaction of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one(cas: 168297-86-7).Formula: C8H15NO2

The Article related to epothilone fragment preparation julia kocienski olefination, Biomolecules and Their Synthetic Analogs: Other Bacterial and Fungal Metabolites and other aspects.Formula: C8H15NO2

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

On October 31, 2019, Zhu, Jidong; Cao, Hengyi; Sun, Lin published a patent.Name: (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one The title of the patent was Preparation of aminopyrimidine derivatives useful for the treatment of diseases associated with IDH mutation. And the patent contained the following:

The invention relates to aminopyrimidine derivatives of formula I, method for their preparation and their use for preventing and treating a disease associated with IDH mutation. Compounds of formula I, wherein A1 is a bond, CH2, CR2O, CR=CH, O, S, etc.; A2 to A10 are independently CR2, CHR, NR, O, S, etc.; B1 to B3 are independently CR and N; dotted bond is absent or double bond; R is H, halo, CN, (un)substituted C1-4alkyl, etc.; R4 and R6 are independently H, D, Me, Et, CF3, etc.; R1, R2, R3 and R5 are independently H, OH, halo, CN, etc.; D is (CH2)0-3, and their stereoisomers, racemates, pharmaceutically acceptable salts, are claimed. Example compound II was prepared via a multistep procedure (procedure given). All the invention compounds were evaluated for their isocitrate dehydrogenase 1 (IDH1) inhibitory activity. The experimental process involved the reaction of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one(cas: 168297-86-7).Name: (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one

The Article related to aminopyrimidine derivative preparation treatment cancer idh mutation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Name: (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

On November 5, 2010, Ohtani, Takashi; Tsukamoto, Shinya; Kanda, Hiroshi; Misawa, Kensuke; Urakawa, Yoshifumi; Fujimaki, Takahiro; Imoto, Masaya; Takahashi, Yoshikazu; Takahashi, Daisuke; Toshima, Kazunobu published an article.Application of 168297-86-7 The title of the article was Total Synthesis of Incednam, the Aglycon of Incednine. And the article contained the following:

The first total synthesis of incednam I (R = H), the aglycon of the macrolactam antibiotic incednine I (R = II), is described. Incednine has been reported to exhibit significant inhibitory activity against the antiapoptotic oncoproteins Bcl-2 and Bcl-xL. The synthesis of I (R = H) commenced with the preparation of the C1-C13 subunit III and the C14-C23 subunit IV. The construction of the novel 24-membered macrocycle was achieved by the application of a Stille coupling between III and IV, followed by macrolactamization. The experimental process involved the reaction of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one(cas: 168297-86-7).Application of 168297-86-7

The Article related to incednam incednine aglycon preparation stille coupling macrolactamization, Biomolecules and Their Synthetic Analogs: Other Bacterial and Fungal Metabolites and other aspects.Application of 168297-86-7

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

On January 6, 2017, Sagawa, Naoya; Moriya, Hiroki; Hosokawa, Seijiro published an article.Application In Synthesis of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one The title of the article was Syn Selective Vinylogous Mukaiyama Aldol Reaction Using Z,E-Vinylketene N,O-Acetal with Acetals. And the article contained the following:

Stereoselective vinylogous Mukaiyama aldol reactions using the Z,E-vinylketene silyl N,O-acetal possessing a chiral auxiliary, derived from (E)-3-pentenoic acid and L-valine, have been achieved. The reaction proceeded smoothly to give a syn adduct in high stereoselectivity. Since the products possess structures including δ-alkoxy-γ-methyl-α,β-unsaturated imide, this reaction would be applicable to synthesize polyketides in a short procedure. The experimental process involved the reaction of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one(cas: 168297-86-7).Application In Synthesis of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one

The Article related to stereoselective vinylogous mukaiyama aldol vinylketene silyl acetal chiral auxiliary, alkoxy methyl unsaturated imide synthesis, polyketide synthesis, Biomolecules and Their Synthetic Analogs: Other Bacterial and Fungal Metabolites and other aspects.Application In Synthesis of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

On November 30, 2009, Concellon, Carmen; Duguet, Nicolas; Smith, Andrew D. published an article.Reference of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one The title of the article was N-Heterocyclic Carbene-Mediated Enantioselective Addition of Phenols to Unsymmetrical Alkylarylketenes. And the article contained the following:

Chiral N-heterocyclic carbenes (NHCs) mediate the enantioselective addition of 2-phenylphenol to unsym. alkylarylketenes, delivering α-alkyl-α-arylacetic acid derivatives with good levels of enantiocontrol (up to 84% ee). Enantiodivergent stereochem. outcomes are observed using 2-phenylphenol and benzhydrol in the NHC-promoted esterification reaction using a triazolium precatalyst derived from pyroglutamic acid, consistent with distinct mechanistic pathways operating within these processes. The experimental process involved the reaction of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one(cas: 168297-86-7).Reference of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one

The Article related to addition stereoselective phenol alkylarylketene n heterocyclic carbene catalyst, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Esters, Acyl Peroxides, Acyl Halides and other aspects.Reference of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

On October 17, 2005, Kinoshita, Hironori; Takahashi, Natsuko; Iwamura, Tatsunori; Watanabe, Shin-ichi; Kataoka, Tadashi; Muraoka, Osamu; Tanabe, Genzoh published an article.Electric Literature of 168297-86-7 The title of the article was Synthesis of 3-sulfanylpropanols containing three consecutive stereocenters via tandem Michael-aldol reaction of enoyl thioamides with acetals as key reaction. And the article contained the following:

(2S,3S,1’R)-2-(α-Methoxybenzyl)-3-phenyl-3-sulfanylpropionamides were diastereoselectively prepared by the reaction of N-cinnamoyl-4S-isopropyl-5,5-dimethyloxazolidinethione with acetals in the presence of SnCl4. The absolute configuration of the three newly created contiguous stereocenters was determined by the x-ray anal. of the disulfide [orthorhombic, space group P212121, a 20.404(4), b 23.153(3), c 11.679(3) Å, V 5517(1) Å3, Z 4]. The amides were transformed into propanols by the reductive removal of the oxazolidinone moiety. The experimental process involved the reaction of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one(cas: 168297-86-7).Electric Literature of 168297-86-7

The Article related to sulfanylpropanol asym synthesis, enoyl thioamide acetal tandem stereoselective michael aldol, oxazolidinyloxopropyl disulfide preparation mol crystal structure, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Alcohols and Thiols and other aspects.Electric Literature of 168297-86-7

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem