Category: 168297-86-7

On May 3, 2018, Huang, Hui; Lanter, James C.; Meegalla, Sanath K.; Player, Mark R. published a patent.Recommanded Product: 168297-86-7 The title of the patent was Preparation of cyclohexyl derivatives as GPR40 agonists for the treatment of type II diabetes. And the patent contained the following:

Disclosed are compounds of formula I, compositions and methods for treating of disorders that are affected by the modulation of the GPR40 receptor. Compounds of formula I wherein G is 5-C1-3 alkoxy-2-fluorophenyl, 2-C1-3 alkoxy-5-fluoropyridin-4-yl, 6-methoxypyrazin-2-yl-4-methoxypyrimidin-2-yl, 2-ethyl-5-fluorophenyl and 2-ethyl-5-fluoropyridin-4-yl; R1 is H, OH, MeO and F; Ra is H and C1-4 alkyl; L is OCH2, NHCH2, CH2CH2 and CH:CH; ring W is Ph and pyridinyl; R2 is C3-5 cycloalkyl, methoxyacetylenyl, and EtO; R3 is H, Me, CF3 and F; A is carboxy and 1H-tetrazol-5-yl; and enantiomers, diastereoisomers and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by a multistep procedure (procedure given). The example compounds were evaluated for their GPR40 agonistic activity. From the assay, it was determined that compound II exhibited IC50 values in the range of 0.0005 μM tp 0.0028 μM. The experimental process involved the reaction of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one(cas: 168297-86-7).Recommanded Product: 168297-86-7

The Article related to cyclohexyl derivative preparation gpr40 agonist treatment diabetes type ii, Alicyclic Compounds: Cyclohexanes and other aspects.Recommanded Product: 168297-86-7

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

On October 5, 2012, Ivashkin, Pavel; Couve-Bonnaire, Samuel; Jubault, Philippe; Pannecoucke, Xavier published an article.COA of Formula: C8H15NO2 The title of the article was Asymmetric synthesis of cyclopropanes with a monofluorinated quaternary stereocenter. And the article contained the following:

New chiral fluorinated reagents (N-(dibromofluoroacetyl)oxazolidinones) were easily synthesized and used in an asym. cyclopropanation process. The Michael initiated ring closure reaction provided chiral cyclopropanes bearing a fluorinated quaternary stereocenter. Various electron-deficient alkenes can be used to efficiently obtain chiral polysubtituted fluorinated cyclopropanes in good yields. Moderate to very good cis/trans ratios were obtained with a high level of diastereoselectivity for each isomer. The experimental process involved the reaction of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one(cas: 168297-86-7).COA of Formula: C8H15NO2

The Article related to fluorocyclopropane enantioselective preparation, dibromofluoroacetyl oxazolidinone preparation acrylate asym cyclopropanation, Alicyclic Compounds: Cyclopropanes and other aspects.COA of Formula: C8H15NO2

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

On October 3, 2019, Qiu, Yao-Ling; Kass, Jorden; Suh, Byung-Chul; Cao, Hui; Li, Wei; Peng, Xiaowen; Gao, Xuri; Or, Yat Sun published a patent.Application In Synthesis of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one The title of the patent was Hepatitis B antiviral agents. And the patent contained the following:

The present invention discloses compounds of Formula (I; W and Y are each N and Z is CR10; or W is C, one of Y and Z is N and the other is NR11; R10 is hydrogen, halo, or optionally substituted C1-C6 alkyl; R11 is hydrogen, etc.), and pharmaceutically acceptable salts, esters, or prodrugs thereof which inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV life cycle of the hepatitis B virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HBV infection. The invention also relates to methods of treating an HBV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The experimental process involved the reaction of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one(cas: 168297-86-7).Application In Synthesis of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one

The Article related to hepatitis b virus antiviral, Pharmaceuticals: Formulation and Compounding and other aspects.Application In Synthesis of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

On January 17, 2014, Mabe, Phillip J.; Zakarian, Armen published an article.Category: oxazolidine The title of the article was Asymmetric Radical Addition of TEMPO to Titanium Enolates. And the article contained the following:

A mild method for α-hydroxylation of N-acyl oxazolidinones by asym. radical addition of the 2,2,6,6-tetramethylpiperidine N-oxy (TEMPO) radical to titanium enolates was developed. The high diastereoselectivity and broad scope of the reaction show synthetic utility for the α-hydroxylation of substrates that are not tolerant to strongly basic conditions. The experimental process involved the reaction of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one(cas: 168297-86-7).Category: oxazolidine

The Article related to asym radical addition tempo titanium enolate alpha hydroxylation, General Organic Chemistry: Synthetic Methods and other aspects.Category: oxazolidine

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

On July 8, 2015, Jimenez, Jacqueline; Ramirez, JuanCarlos; Huelgas, Gabriela; Melendrez, Ruth; Cabrera-Vivas, Blanca M.; Sansinenea, Estibaliz; Ortiz, Aurelio published an article.Quality Control of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one The title of the article was ‘Syn-effect’ in the diastereoselective alkylation of 3-[(E)-α,β-unsaturated-γ-substituted]-N-acyloxazolidinones. And the article contained the following:

Synthetic methods for the formation of alkenes usually produce the E-alkene because it is more stable. However, in isomerization reaction (double bond migration) that takes place in α, β-unsaturated carbonyl compounds, when these carbonyl compounds are exposed to strong bases, furnish Z-alkenes highly stereoselective depending on the γ-substituent in the α, β-unsaturated carbonyl. This stereoselectivity can be attributed to the known Syn-effect. The synthetic value of this methodol. is the achievement of chiral alc. bearing an electron rich Z-alkene, as well as substituted, which was accomplished via removal of the oxazolidinone moiety under treatment with NaBH4, THF-H2O. The experimental process involved the reaction of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one(cas: 168297-86-7).Quality Control of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one

The Article related to syn effect stereoselective alkylation unsaturated acyloxazolidinone, General Organic Chemistry: Synthetic Methods and other aspects.Quality Control of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

On March 31, 1995, Davies, Stephen G.; Sanganee, Hitesh J. published an article.Safety of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one The title of the article was 4-Substituted-5,5-dimethyl Oxazolidin-2-ones as effective chiral auxiliaries for enolate alkylations and Michael additions. And the article contained the following:

4-(Me, Ph, benzyl, and i-propyl)-5,5-dimethyloxazolidin-2-ones, readily available from α-amino acids, are shown to be effective chiral auxiliaries for stereoselective enolate alkylations and conjugate additions of attached N-acyl moieties. Thus, e.g., diastereoselective benzylation of the N-propionyl derivatives I (R = Me, Ph, benzyl, iso-Pr) afforded II (% yield/% d.e. in order of R: 85/90; 63/81; 51/95; 22/97). The experimental process involved the reaction of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one(cas: 168297-86-7).Safety of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one

The Article related to oxazolidinone dimethyl chiral auxiliary, chiral auxiliary dimethyloxazolidinone, stereoselective enolate alkylation michael addition dimethyloxazolidinone, General Organic Chemistry: Synthetic Methods and other aspects.Safety of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

On March 5, 2021, Obrien, Kevin T.; Nadraws, Jonathan W.; Smith, Amos B. III published an article.Synthetic Route of 168297-86-7 The title of the article was A Difluoromethylene Linchpin/Synthon: Application in Conjunction with Anion Relay Chemistry (ARC) Permits Ready Access to Diverse Difluoromethylene Scaffolds. And the article contained the following:

Organodifluorine synthons, in conjuction with three-component diastereoselective anion relay chem. (ARC), permit ready access to diverse difluoromethylene scaffolds. Initiated via [1,2]-addition of an organolithium reagent to a β-difluoromethylene silyl aldehyde, an alkoxide intermediate is formed, which is capable of undergoing a [1,4]-Brook rearrangement to generate a stabilized α-difluoromethylene carbanion, which, upon electrophile capture, affords a three-component adduct. This three component synthetic tactic represents a novel one-pot divergent strategy for the construction of diverse organodifluorine containing compounds The experimental process involved the reaction of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one(cas: 168297-86-7).Synthetic Route of 168297-86-7

The Article related to aldehyde difluoromethylene silyl electrophile diastereoselective anion relay, difluoromethylene scaffold stereoselective preparation, Aliphatic Compounds: Halides and Halonium Compounds and other aspects.Synthetic Route of 168297-86-7

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

On June 30, 2016, Shiers, Jason John; Watts, John Paul; Onions, Stuart Thomas; Abdul Quddus, Mohammed; Wrigglesworth, Joseph William; Sambrook-Smith, Colin Peter; Naylor, Alan; Londesbrough, Derek published a patent.Synthetic Route of 168297-86-7 The title of the patent was Preparation of pyridine, pyridazine and triazine derivatives for the treatment of cancer and/or other diseases. And the patent contained the following:

Title compounds I [one of Q1 and Q2 = N and the other = CH, or both Q1 and Q2 = N, and Q3 = CH; or Q1 , Q2 and Q3 = N; A = (un)substituted five- or six-membered aromatic ring; R1 = aliphatic carbocyclic or heterocyclic ring; R2 = H, alkyl or halo; R3 = aryl or heteroaryl; R5 and R6 independently = H or alkyl] and their pharmaceutically acceptable salts, are prepared and disclosed for the treatment of cancer. Thus, II was prepared in a multi-step synthesis starting from Et 2-(trans-4-aminocyclohexyl)acetate hydrochloride with CbzCl. Compounds of the invention were tested for their inhibitory activity in Akt activation assay, e.g., compound II showed IC50 value of 780 nM, 110 nM and 15 nM against Akt1 and Akt2 and Akt3. The experimental process involved the reaction of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one(cas: 168297-86-7).Synthetic Route of 168297-86-7

The Article related to pyridine pyridazine triazine preparation cancer, Heterocyclic Compounds (More Than One Hetero Atom): Triazines and other aspects.Synthetic Route of 168297-86-7

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

On December 29, 2005, Merrill, Bryon A.; Haraldson, Chad A.; Kshirsagar, Tushar A.; Niwas, Shri published a patent.Electric Literature of 168297-86-7 The title of the patent was Preparation of imidazoquinoline and imidazonaphthyridine derivatives as immunomodulators of cytokine biosynthesis. And the patent contained the following:

The title imidazoquinoline and imidazonaphthyridine derivatives I [wherein R1 and R2 together form a benzene or pyridine ring which is optionally substituted with heterocyclyl; R3 and R4 = independently H or a substituent] or pharmaceutically acceptable salts thereof were prepared as immunomodulators of cytokine biosynthesis for the treatment of viral infection and cancer. For example, the compound II was prepared in a multi-step synthesis. Some of compounds I showed strong inhibitory effect on TNF-α in rat. The experimental process involved the reaction of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one(cas: 168297-86-7).Electric Literature of 168297-86-7

The Article related to preparation imidazoquinoline imidazonaphthyridine immunomodulator cytokine antiviral agent antitumor human, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Electric Literature of 168297-86-7

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

On June 30, 2000, Bew, Sean P.; Davies, Stephen G.; Fukuzawa, Shin-Ichi published an article.COA of Formula: C8H15NO2 The title of the article was Kinetic resolution of α-acetoxy carboxylic acids with homochiral SuperQuats. And the article contained the following:

Preliminary investigations focused on the kinetic resolution of (±)-O-acetyl mandelic acid chloride with iso-Pr SuperQuat and iso-Pr Evans’ homochiral auxiliaries. The addition of 2 equiv of the acid chloride to the lithium salts of the auxiliaries (SuperQuat and Evans’) at -100° in THF afforded the N-acyl auxiliaries in high chem. yields (95 and 89%) and d.e.’s of 66 and 40%, resp. Using the same mandelic acid chloride but incorporating SuperQuat auxiliaries derived from (S)-phenylglycine and (S)-phenylalanine gave the N-acyl SuperQuats in 86 and 90% yield and d.e.’s of 66 and 30%, resp. Replacing the Ph group in the O-acetyl mandelic acid chloride with a Bu, tert-Bu, or cyclohexyl group changed the d.e. significantly when kinetically resolved with iso-Pr SuperQuat. The yields were all similar, i.e., ∼90%, but the d.e.’s varied considerably, with values of 20, 50, and 82%, resp. Attempted kinetic resolution of α-methoxy-phenylacetyl chloride using the lithium salt of iso-Pr SuperQuat revealed a diastereoselectivity of 45%, significantly lower than that obtained with the corresponding α-acetoxy carboxylic acid chlorides. The experimental process involved the reaction of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one(cas: 168297-86-7).COA of Formula: C8H15NO2

The Article related to acetoxy acid chloride kinetic resolution superquat, Heterocyclic Compounds (More Than One Hetero Atom): Oxazoles, Isoxazoles and other aspects.COA of Formula: C8H15NO2

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem