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Novel thermoplastic elastomers based on multi-block copolymers of poly(l-lysine) (PLL), poly(N-epsilon-carbobenzyloxyl-l-lysine) (PZLL), poly(epsilon-caprolactone) (PCL), and poly(ethylene glycol) (PEG) were synthesized by combination of ring-opening polymerization (ROP) and chain extension via l-lysine diisocyanate (LDI). SEC and 1H NMR were used to characterize the multi-block copolymers, with number-average molecular weights between 38,900 and 73,400 g/mol. Multi-block copolymers were proved to be good thermoplastic elastomers with Young’s modulus between 5 and 60 MPa and tensile strain up to 1300%. The PLL-containing multi-block copolymers were electrospun into non-woven mats that exhibited high surface hydrophilicity and wettability. The polypeptide?polyester materials were biocompatible, bio-based and environment-friendly for promising wide applications.

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Oxazolidine – Wikipedia,
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Nanoparticle vesicles were spontaneously assembled from homopolymer polyamine polyelectrolytes and water-soluble, citrate-stabilized quantum dots. The further addition of silica nanoparticles to a solution of quantum dot vesicles generated stable micrometer-sized hollow spheres whose walls were formed of a thick, inner layer of close-packed quantum dots followed by an outer layer of silica. The method employed here to assemble both the nanoparticle vesicles and the hollow spheres is in direct contrast to previous syntheses that use either tailored block copolymers or oil-in-water emulsion templating. We propose that the formation of charge-stabilized hydrogen bonds between the positively charged amines of the homopolymer polyelectrolytes and the negatively charged citrate molecules stabilizing the quantum dots is responsible for the macroscopic phase separation in this completely aqueous system. The ease and processibility of the present approach gives promise for the production of a diverse array of materials ranging in applications from drug delivery to catalysis to micrometer-scale optical devices.

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Oxazolidine – Wikipedia,
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Introduction: Advanced tumor-targeted theranostic nanoparticles play a key role in tumor diagnosis and treatment research. In this study, we developed a multifunctional theranostic platform based on an amphiphilic hyaluronan/poly-(N-epsilon-carbobenzyloxy-L-lysine) derivative (HA-g-PZLL), superparamagnetic iron oxide (SPIO) and aggregation-induced emission (AIE) nanoparticles for tumor-targeted magnetic resonance (MR) and fluorescence (FL) dual-modal image-guided photodynamic therapy (PDT). Materials and Methods: The amphiphilic hyaluronan acid (HA) derivative HA-g-PZLL was synthesized by grafting hydrophobic poly-(N-epsilon-carbobenzyloxy-L-lysine) (PZLL) blocks onto hyaluronic acid by a click conjugation reaction. The obtained HA-g-PZLLs self-assembled into nanoparticles in the presence of AIE molecules and SPIO nanoparticles to produce tumortargeted theranostic nanoparticles (SPIO/AIE@HA-g-PZLLs) with MR/FL dual-modal imaging ability. Cellular uptake of the theranostic nanoparticles was traced by confocal laser scanning microscopy (CLSM), flow cytometry and Prussian blue staining. The intracellular reactive oxygen species (ROS) generation characteristics of the theranostic nanoparticles were evaluated with CLSM and flow cytometry. The effect of PDT was evaluated by cytotoxicity assay. The dual-mode imaging ability of the nanoparticles was evaluated by a real-time near-infrared fluorescence imaging system and magnetic resonance imaging scanning. Results: The resulting theranostic nanoparticles not only emit red fluorescence for highquality intracellular tracing but also effectively produce singlet oxygen for photodynamic tumor therapy. In vitro cytotoxicity experiments showed that these theranostic nanoparticles can be efficiently taken up and are mainly present in the cytoplasm of HepG2 cells. After internalization, these theranostic nanoparticles showed serious cytotoxicity to the growth of HepG2 cells after white light irradiation. Discussion: This work provides a simple method for the preparation of theranostic nanoparticles with AIE characteristics and MR contrast enhancement, and serves as a dual-modal imaging platform for image-guided tumor PDT.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H2749NO – PubChem

Application of 1676-86-4, Career opportunities within science and technology are seeing unprecedented growth across the world, and those who study chemistry or another natural science at university now have increasingly better career prospects. In a article, 1676-86-4, molcular formula is C15H18N2O5, introducing its new discovery.

Polypeptides have attracted widespread attention as building blocks for complex materials due to their ability to form higher-ordered structures such as beta-sheets. However, the ability to precisely control the formation of well-defined beta-sheet-assembled materials remains challenging as beta-sheet formation tends to lead to ill-defined and unprocessable aggregates. This work reports a simple, rapid, and robust strategy to form well-defined peptide beta-sheet-assembled shells (i.e., hollow spheres) by employing surface-initiated N-carboxyanhydride ring-opening polymerization under a highly efficient surface-driven approach. The concept is demonstrated by the preparation of enzyme-degradable rigid shell architectures composed of H-bonded poly(L-valine) (PVal) grafts with porous and sponge-like surface morphology. The porous PVal-shells exhibit a remarkable and unprecedented ability to non-covalently entrap metal nanoparticles, proteins, drug molecules, and biorelevant polymers, which could potentially lead to a diverse range of biodegradable and functional platforms for applications ranging from therapeutic delivery to organic catalysis.

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. A catalyst does not appear in the overall stoichiometry of the reaction it catalyzes. You can also check out more blogs about 1676-86-4Application of 1676-86-4

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Oxazolidine – Wikipedia,
Oxazolidine | C3H2743NO – PubChem

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In this work we compare chemical and solution properties, like critical aggregate concentrations (CAC) and hydrodynamic radii of aggregates based on either poly(ethylene glycol) or poly(sarcosine) block copolymers in aqueous solution. The amine functionalized, hydrophilic polymers poly(sarcosine) (degree of polymerization, Xn = 100 and 200) and PEG (Xn = 121 and 242) of comparable hydrodynamic volume were used to initiate the ring opening polymerization of alpha-amino acid-N-carboxyanhydrides based on epsilon-benzyl-l-glutamate (Glu(OBn)) or epsilon-carboxybenzyl-l-lysine (Lys(Z)). The second, hydrophobic block was kept at a degree of polymerization of 25 and 50 to enable a direct comparison of solution properties of block copolymers. In both cases block length could be precisely adjusted and all synthesized block copolymers have narrow molecular weight distributions and dispersities between 1.1 and 1.2. Both types of block copolymers display critical aggregate concentrations in the range of 6?10-8-3?10-7 mol/L and aggregates possess hydrodynamic radii in a range of 40-100 nm. PEG based systems, however, have a slightly lower CAC and tend to form smaller micelles, while PSar based systems have commonly smaller mu2 parameter indication more uniform aggregates.

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Oxazolidine – Wikipedia,
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1676-86-4, Name is (S)-Benzyl (4-(2,5-dioxooxazolidin-4-yl)butyl)carbamate, belongs to oxazolidine compound, is a common compound. Formula: C15H18N2O5In an article, once mentioned the new application about 1676-86-4.

Two thermo- and pH-sensitive polypeptide-based copolymers, poly(N-isopropylacrylamide-co-N-hydroxymethylacrylamide)-b-poly(L-lysine) (P(NIPAAm-co-HMAAm)-b-PLL, P1) and poly(N-isopropylacrylamide-co-N- hydroxymethylacrylamide)-b-poly(glutamic acid) (P(NIPAAm-co-HMAAm)-b-PGA, P2), have been designed and synthesized by the ring-opening anionic polymerization of N-carboxyanhydrides (NCA) with amino-terminated P(NIPAAm-co-HMAAm). It was found that the block copolymers exhibit good biocompatibility and low toxicity. As a result of electrostatic interactions between the positively charged PLL and negatively charged PGA, P1 and P2 formed polyion complex (PIC) micelles consisting of polyelectrolyte complex cores and P(NIPAAm-co-HMAAm) shells in aqueous solution. The thermo- and pH-sensitivity of the PIC micelles were studied by UV/Vis spectrophotometry, dynamic light scattering (DLS), and transmission electron microscopy (TEM). Moreover, fluorescent PIC micelles were achieved by introducing two fluorescent molecules with different colors. Photographs and confocal laser scanning microscopy (CLSM) showed that the fluorescence-labeled PIC micelles exhibit thermo- and pH-dependent fluorescence, which may find wide applications in bioimaging in complicated microenvironments. Copyright

The potential utility of systematic synthetic strategy will be applicable to efficient generations of chemical libraries of compounds to find ‘hit’ molecules.Read on for other articles about 1676-86-4Formula: C15H18N2O5

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Oxazolidine – Wikipedia,
Oxazolidine | C3H2728NO – PubChem

Having gained chemical understanding at molecular level, chemistry graduates may choose to apply this knowledge in almost unlimited ways, as it can be used to analyze all matter and therefore our entire environment. In a patent, 1676-86-4, name is (S)-Benzyl (4-(2,5-dioxooxazolidin-4-yl)butyl)carbamate, introducing its new discovery. Electric Literature of 1676-86-4

Amphiphilic block copolypeptides were prepared through transition-metal- mediated polymerization of amino acid N-carboxyanhydrides. In aqueous solution these materials form strong hydrogels at low concentrations. The self-assembly process that is responsible for gelation was investigated by measuring the rheological properties of the gels for a variety of molecular architectures: poly-L-lysine-&-poly-L-leucine diblock and poly-L-lysine-b-poly-L-leucine-b- poly-L-lysine triblock copolypeptides. Experiments showed that the rodlike helical secondary structure of enantionierically pure poly-L-leucine blocks was instrumental for gelation at polypeptide concentrations as low as 0.25 wt %. The hydrophilic polyelectrolyte segments have stretched coil configurations and stabilize the twisted fibril assemblies by forming a corona around the hydrophobic core. The self-assembly of hydrophobic blocks is highly specific and sensitive to the chirality of the helices. It was found that mechanical properties of the gels can be tuned through the molecular architecture of the block copolypeptides and also by carefully mixing different polypeptides in solution.

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Multifunctional Biotin-PEG-b-PLL(Mal)-peptide-DOX polymeric micelles were prepared to selectively eliminate cancer cells. The micelles were able to enhance cancer cell uptake via the receptor-mediated endocytosis and respond to the stimulus of cancer cell excessive secreted protease MMP-2 to release the anticancer drug and induce apoptosis of cancer cells in a targeted manner. This journal is

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Oxazolidine – Wikipedia,
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High transfection efficiency and low cytotoxicity are the two key factors to be considered in the design of gene carriers. Herein, a novel and versatile gene carrier (PLL-RT) was prepared by introducing “molecular string” RT (i.e., p-toluylsulfonyl arginine) onto the polylysine backbone. The introduction of RT string contributed to the formation of multiple interactions between the polycationic gene carriers and cell membrane or DNA, as well as adopting alpha-helix conformation, all of which would be beneficial to enhance the gene transfection. In addition, RT string grafted onto other polycations such as hyperbranced PEI25k and dendrimer PAMAM could also acquire improved transfection efficiency and low cytotoxicity. Moreover, PLL-RT presented significant tumor inhibition effect in vivo. This work provided an effective strategy for constructing novel gene carriers with high transfection and low cytotoxicity.

Future efforts will undeniably focus on the diversification of the new catalytic transformations. These may comprise an expansion of the substrate scope from aromatic and heteroaromatic compounds to other hydrocarbons. Keep reading other articles of 1676-86-4. Recommanded Product: 1676-86-4

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Oxazolidine – Wikipedia,
Oxazolidine | C3H2709NO – PubChem

Chemistry is traditionally divided into organic and inorganic chemistry. Electric Literature of 1676-86-4, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent，Which mentioned a new discovery about 1676-86-4

A near infrared fluorescent polymeric drug delivery system (NIRF DDS) with pH-responsive drug release properties has been designed and developed. This material was prepared by chemical conjugation of the anticancer drug doxorubicin and hydrophobic aminocyanine dye to triblock copolypeptide via hydrazone and amide bonds, respectively. Conjugation with aminocyanine shows almost no toxicity of the material, while conjugation with doxorubicin induces pronounced toxicity on the original biocompatible material. The pH sensitive drug release nature of the near infrared fluorescent polymeric drug (NIRF prodrug) was confirmed by accelerated drug release at pH of 5.0 via an in vitro drug release experiment and gradual drug cleavage from the NIRF prodrug during a confocal laser scanning microscopic (CLSM) experiment. The CLSM experiment also reveals that the released drug subsequently migrated to the nucleus, while the polymeric residue still remained in cytoplasm, indicating that the as-prepared polymer can be a promising candidate for theranosis of cancer.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H2747NO – PubChem