Preparation and characterization of metaxalone nanoparticles prepared by high pressure homogenization was written by Gubbala, Lakshmi Prasanna;Arutla, Srinivas;Venkateshwarlu, Vobalaboina. And the article was included in American Journal of PharmTech Research in 2016.Synthetic Route of C12H15NO3 This article mentions the following:
The aim of present work was to enhance the dissolution of poorly soluble drug metaxalone by particle size reduction Metaxalone nanoparticles are obtained by high pressure homogenization followed by drying, which are characterized for mean particle size (MPS), polydispersityindex( PDI), zeta-potential(ZP), X-ray diffraction(XRD), Differential scanning calorimetry(DSC), Fourier-transform infra-red(FTIR), SEM (SEM), flow properties, saturation solubility and in-vitro release. The MPS of nanoparticles was observed to be less than 200 nm. The neg. ZP indicates the stable nanoparticles obtained by sufficient adsorption of the stabilizers onto drug surface. The XRD and DSC show the retention of drug crystallinity. Out of three drying methods, SD and SG have obtained stable nanoparticles with improved flow properties. Nanoparticles increased the drug solubility by approx. 4 folds with Hydroxy Pr Me cellulose and sodium lauryl sulfate as surface stabilizers. In-vitro release studies showed a remarkable increase in rate of drug release from 3 % (pure drug) to 34-36 % (nanoparticles) after 15 min and at the end of dissolution study almost 95 % of drug dissolved when compared to only 30 % of pure drug. The combining methods of HPH followed by SD/SG was observed to be promising method to produce stable nanoparticles of metaxalone with remarkable increase dissolution rate.. Results from this study suggest that these metaxalone nanoparticles may be a potential candidate for oral administration with quick onset of action for relief of acute painful musculoskeletal conditions. In the experiment, the researchers used many compounds, for example, 5-((3,5-Dimethylphenoxy)methyl)oxazolidin-2-one (cas: 1665-48-1Synthetic Route of C12H15NO3).
5-((3,5-Dimethylphenoxy)methyl)oxazolidin-2-one (cas: 1665-48-1) belongs to oxazolidine derivatives.Oxazolidines are readily available also from propargyl amines. Oxazolidines are cyclic condensation products of β-amino alcohols and aldehydes or ketone, and they undergo a facile and complete hydrolysis in aqueous solution. Alterations in carbonyl moiety control the rate of formation of a given β-amino alcohol. Oxazolidines are weaker bases (pKa 6–7) than parent β-amino alcohols and found to be more lipophilic than the parent compound at physiological pH.Synthetic Route of C12H15NO3
Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem